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Objective To investigate risk factors for acute phase reaction (APR) induced by zoledronic acid (ZA) treatment in osteoporosis and its impact on treatment adherence and persistence. Methods A retrospective analysis was conducted using clinical data from 471 osteoporosis patients with a median age of 67 years, who received 5 mg ZA in the First Affiliated Hospital of Chongqing Medical University between January 2013 and January 2022. Patients were divided into two groups based on the occurrence of APR: APR group (n=79) and non-APR group (n=392). Univariate and multivariate logistic regression analyses were used to identify factors inducing APR. The treatment persistence of ZA was analyzed using Kaplan-Meier curves. In addition, treatment adherence was analyzed. Results The incidence of APR was 33.2% after the first ZA injection, and it gradually decreased with an increase in the number of infusions. The multivariate logistic regression analysis showed that the first infusion, no history of oral bisphosphonate use, and high blood phosphorus levels were independent risk factors for APR. Three-year treatment adherence and persistence in APR group were 53% and 44%, respectively, while in non-APR group, they were 52% and 42%, respectively. Kaplan-Meier analysis showed no statistically significant difference in the persistence of ZA between two groups (P>0.05). Conclusions APR is prone to occur during ZA treatment for osteoporosis, but it does not affect the adherence and persistence of ZA treatment. First use of ZA, no history of oral bisphosphonates, and high blood phosphorus levels are independent risk factors for APR.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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