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Application of smart responsive materials in the precise repair of osteonecrosis of the femoral head
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Hao Chen1, Hong-Zhong Xi1, Peng Xue1, Shuai He1, Xiao-Xue Tan2, Guang-Quan Sun1, Xin Liu1, Xiao-Hong Jiang2, Bin Du1, *
Medical Journal of Chinese People’s Liberation Army | 2024, 49(7) : 841 - 847
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(7): 841-847
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Application of smart responsive materials in the precise repair of osteonecrosis of the femoral head
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Hao Chen1, Hong-Zhong Xi1, Peng Xue1, Shuai He1, Xiao-Xue Tan2, Guang-Quan Sun1, Xin Liu1, Xiao-Hong Jiang2, Bin Du1, *
Affiliations
  • 1Department of Orthopedics and Traumatology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China
  • 2Academy of Chemical Engineering and Technology, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China
Published: 2024-07-28 doi: 10.11855/j.issn.0577-7402.0673.2023.1010
Outline
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Osteonecrosis of the femoral head (ONFH) is a common orthopedic disease, and hip preservation surgery has high clinical value in the early stages of ONFH, especially for young and middle-aged patients. However, the repair of ONFH is heterogeneous, leading to inter-individual variations in the efficacy of hip preservation. Currently, the existing tissue-engineered scaffolds in the field of hip preservation are uncontrollable after implantation, making it difficult to achieve precise repair. Smart responsive materials have good biocompatibility and self-feedback capability. By combining them with therapeutic drugs to construct stimulus-responsive drug delivery systems, new possibilities are provided for the precise repair of ONFH. This paper reviews the research progress of smart responsive materials at home and abroad. Based on the response principles of various materials and the repair characteristics of ONFH, the application prospects of various smart responsive materials such as reactive oxygen species-responsive, fluid shear stress-responsive, and light/magnetic-responsive materials are discussed and prospected in the field of precise repair for ONFH, providing new ideas for the precise treatment of ONFH.

smart responsive materials  /  femoral head osteonecrosis  /  heterogeneity repair  /  precise repair  /  application prospects
Hao Chen, Hong-Zhong Xi, Peng Xue, Shuai He, Xiao-Xue Tan, Guang-Quan Sun, Xin Liu, Xiao-Hong Jiang, Bin Du. Application of smart responsive materials in the precise repair of osteonecrosis of the femoral head[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (7) : 841 -847 . DOI: 10.11855/j.issn.0577-7402.0673.2023.1010
Funding
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  • National Natural Science Foundation of China(82074471)
  • Intergovernmental Cooperation Projects in the National Key Research and Development Plan of the Ministry of Science and Technology of PRC(2022YFE0196800)
  • Jiangsu Provincial Health and Health Commission Scientific Research Project(K2019027)
  • Priority Academic Program Development of Jiangsu Higher Education Institutions(035062005001)
Appendix
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Year 2024 volume 49 Issue 7
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249
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Article Info
doi: 10.11855/j.issn.0577-7402.0673.2023.1010
  • Receive Date：2023-05-10
  • Online Date：2025-11-21
  • Published：2024-07-28
Article Data
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History
  • Received：2023-05-10
  • Accepted：2023-07-28
Funding
National Natural Science Foundation of China(82074471)
Intergovernmental Cooperation Projects in the National Key Research and Development Plan of the Ministry of Science and Technology of PRC(2022YFE0196800)
Jiangsu Provincial Health and Health Commission Scientific Research Project(K2019027)
Priority Academic Program Development of Jiangsu Higher Education Institutions(035062005001)
Affiliations
    1Department of Orthopedics and Traumatology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China
    2Academy of Chemical Engineering and Technology, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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