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Advances in the study of linezolid-related adverse reactions of blood and metabolic system
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Jun-Qiang Gou1, 2, Qian Li2, Dong-Feng Yin2, Xiao-Feng Wang2, *
Medical Journal of Chinese People’s Liberation Army | 2024, 49(8) : 965 - 972
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(8): 965-972
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Advances in the study of linezolid-related adverse reactions of blood and metabolic system
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Jun-Qiang Gou1, 2, Qian Li2, Dong-Feng Yin2, Xiao-Feng Wang2, *
Affiliations
  • 1College of Pharmacy, Shihezi University, Shihezi, Xinjiang 832003, China
  • 2Department of Pharmacy, Xinjiang Military Command General Hospital, Urumqi, Xinjiang 830000, China
Published: 2024-08-28 doi: 10.11855/j.issn.0577-7402.1083.2024.0124
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Linezolid, a fully synthetic oxazolidinone antibiotic, is mainly used to treat severe infections caused by Gram-positive drug-resistant bacteria. In recent years, with the rise in drug-resistant bacteria, the clinical utilization rate of linezolid and the incidence of linezolid-related adverse reactions in the hematological system and metabolic system have increased. The main adverse reactions include thrombocytopenia, anemia and lactic acidosis. Studies have shown that the causes of adverse reactions in linezolid-induced hematological system and metabolic system are diverse, and the mechanisms are not fully elucidated. In this review, the pharmacokinetic characteristics, mechanism of adverse reactions, risk factors, as well as preventive measures and individualized drug administration strategies of linezolid in vivo were discussed based on literature reports at home and abroad, aiming to provide references for clinical prevention and treatment of linezolid-related adverse reactions of hematological system and metabolic system.

linezolid  /  blood  /  metabolism  /  adverse reaction  /  individualized drug administration
Jun-Qiang Gou, Qian Li, Dong-Feng Yin, Xiao-Feng Wang. Advances in the study of linezolid-related adverse reactions of blood and metabolic system[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (8) : 965 -972 . DOI: 10.11855/j.issn.0577-7402.1083.2024.0124
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doi: 10.11855/j.issn.0577-7402.1083.2024.0124
  • Receive Date：2023-08-14
  • Online Date：2025-11-21
  • Published：2024-08-28
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  • Received：2023-08-14
  • Accepted：2023-10-07
Affiliations
    1College of Pharmacy, Shihezi University, Shihezi, Xinjiang 832003, China
    2Department of Pharmacy, Xinjiang Military Command General Hospital, Urumqi, Xinjiang 830000, China

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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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