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Research progress on acquired RET fusion induces secondary resistance to EGFR therapy in advanced EGFR-mutated non-small cell lung cancer
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An Wang1, 2, Tao Li1, 2, Di Lu1, 2, Yun-Ye Mao1, 2, Jia-Pei Qin1, 2, Xin Zhou1, 2, Hao Fan1, 2, Yi Hu2, *
Medical Journal of Chinese People’s Liberation Army | 2024, 49(9) : 1080 - 1087
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(9): 1080-1087
• Review •
Research progress on acquired RET fusion induces secondary resistance to EGFR therapy in advanced EGFR-mutated non-small cell lung cancer
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An Wang1, 2, Tao Li1, 2, Di Lu1, 2, Yun-Ye Mao1, 2, Jia-Pei Qin1, 2, Xin Zhou1, 2, Hao Fan1, 2, Yi Hu2, *
Affiliations
  • 1Graduate School, Chinese PLA General Hospital/Medical School of Chinese PLA, Beijing 100853, China
  • 2Department of Oncology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
Published: 2024-09-28 doi: 10.11855/j.issn.0577-7402.0627.2023.1129
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With the in-depth study of molecular biology, non-small cell lung cancer (NSCLC) has opened the era of precision medicine based on mutation-based molecular targeting therapy. Epidermal growth factor receptor (EGFR) driver mutations are closely related to the progression of NSCLC, and EGFR-tyrosine kinase inhibitors (TKIs) developed based on this have achieved significant therapeutic effects, but acquired drug resistance is still one of the major factors limiting their long-term use. As resistance mechanisms are further investigated, in addition to secondary EGFR mutation, MET amplification, HER2 amplification, histologic transformation, etc., receptor tyrosine kinase (RTK) fusion mutation have been shown to be a targetable mechanism of acquired resistance. Among the acquired RTK fusion mutations, rearranged during transfection (RET) fusion mutations are the accessible targets of our concern. As the RET molecule continues to be explored, drugs targeting RET fusions have been approved and marketed. There are different clinical strategies to deal with acquired RET fusion mutation mediating resistance to EGFR-TKIs treatment. In this review, the structure and function of RET, its relationship with EGFR-TKIs resistance, and treatment strategies are reviewed to further improve patient survival outcomes.

non-small cell lung cancer  /  targeted therapy  /  EGFR-TKIs resistance  /  rearranged during transfection
An Wang, Tao Li, Di Lu, Yun-Ye Mao, Jia-Pei Qin, Xin Zhou, Hao Fan, Yi Hu. Research progress on acquired RET fusion induces secondary resistance to EGFR therapy in advanced EGFR-mutated non-small cell lung cancer[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (9) : 1080 -1087 . DOI: 10.11855/j.issn.0577-7402.0627.2023.1129
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  • Major Research Plan of the National Health Commission(GWJJ2021100304)
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Year 2024 volume 49 Issue 9
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Article Info
doi: 10.11855/j.issn.0577-7402.0627.2023.1129
  • Receive Date：2023-04-26
  • Online Date：2025-11-21
  • Published：2024-09-28
Article Data
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History
  • Received：2023-04-26
  • Accepted：2023-08-21
Funding
Major Research Plan of the National Health Commission(GWJJ2021100304)
Affiliations
    1Graduate School, Chinese PLA General Hospital/Medical School of Chinese PLA, Beijing 100853, China
    2Department of Oncology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China

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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
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