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Research progress of neoantigens in tumor immunotherapy
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Jing-Song Chen, Dan Wang*
Medical Journal of Chinese People’s Liberation Army | 2024, 49(10) : 1213 - 1220
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(10): 1213-1220
• Review •
Research progress of neoantigens in tumor immunotherapy
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Jing-Song Chen, Dan Wang*
Affiliations
  • Department of Research, the Second Affiliated Hospital of Xi`an Medical University, Xi'an, Shaanxi 710038, China
Published: 2024-10-28 doi: 10.11855/j.issn.0577-7402.1340.2024.0426
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Tumor neoantigens are antigens encoded by tumor-specific mutated genes, characterized by high specificity, significant exogenous origin, mutation randomness, clonal distribution and correlation with gene mutation. Because these antigens are not negatively screened by the thymus and recognized by T cells as "heterogeneous". They are less easily affected by the immune tolerance mechanism and exhibit strong immunogenicity, making them excellent targets for immunotherapy. Tumor neoantigens can be used to develop therapeutic vaccines, induce and cultivate T cells with stronger targeting capabilities, and are promising for predicting tumor survival prognosis and responses to immune checkpoint blockade therapies. This review summarizes the recent advances in clinical application of tumor neoantigen-based immunotherapy, and prospects for future research directions.

neoantigen  /  tumor  /  immunotherapy  /  clinical trial
Jing-Song Chen, Dan Wang. Research progress of neoantigens in tumor immunotherapy[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (10) : 1213 -1220 . DOI: 10.11855/j.issn.0577-7402.1340.2024.0426
Funding
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  • Key Scientific Research Plan of Shaanxi Provincial Department of Education(20JS141)
  • Youth Project of Shaanxi Provincial Department of Science and Technology(2022JQ-893)
Appendix
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Year 2024 volume 49 Issue 10
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221
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Article Info
doi: 10.11855/j.issn.0577-7402.1340.2024.0426
  • Receive Date：2023-10-11
  • Online Date：2025-11-20
  • Published：2024-10-28
Article Data
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History
  • Received：2023-10-11
  • Accepted：2024-02-27
Funding
Key Scientific Research Plan of Shaanxi Provincial Department of Education(20JS141)
Youth Project of Shaanxi Provincial Department of Science and Technology(2022JQ-893)
Affiliations
    Department of Research, the Second Affiliated Hospital of Xi`an Medical University, Xi'an, Shaanxi 710038, China

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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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