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Protective effect of remazolam on important organs
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Sen Li1, 2, Jin-Xin Lan1, 2, Duo Yang2, Jun-Bing He2, Long-Sheng Zhang1, 2, *
Medical Journal of Chinese People’s Liberation Army | 2024, 49(10) : 1105 - 1109
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Medical Journal of Chinese People’s Liberation Army | 2024, 49(10): 1105-1109
• Special Issue on Mechanisms and Protective Strategies of Perioperative Organ Injury Ⅱ •
Protective effect of remazolam on important organs
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Sen Li1, 2, Jin-Xin Lan1, 2, Duo Yang2, Jun-Bing He2, Long-Sheng Zhang1, 2, *
Affiliations
  • 1The First Clinical Medical College of Guangdong Medical University, Zhanjiang, Guangdong 524023, China
  • 2Department of Anesthesiology, Jieyang People's Hospital, Jieyang, Guangdong 522000, China
Published: 2024-10-28 doi: 10.11855/j.issn.0577-7402.0981.2023.1220
Outline
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Remazolam is a γ-aminobutyric acid (GABA) receptor agonist. It is a short-acting benzodiazepine drug that has just been launched in China in recent years. Its mechanism of action is to enhance inhibitory neurotransmitters of GABA in the central nervous system. It has been widely used in clinical practice for sedation, hypnosis, anti anxiety, and the treatment of insomnia. Meanwhile, remazolam is mainly used for induction and maintenance of general anesthesia during the perioperative period, with a fast onset time and a brief duration of action. Recent studies have shown that remazolam can protect important organs and alleviate organ damage by reducing inflammatory responses and oxidative stress, regulating cell apoptosis, and other pathways. This article summarizes the protective effects and mechanisms of remazolam on the brain, heart, liver, and lung, providing a theoretical basis for the clinical application of remazolam.

remazolam  /  organ protection  /  organ damage  /  inflammation response
Sen Li, Jin-Xin Lan, Duo Yang, Jun-Bing He, Long-Sheng Zhang. Protective effect of remazolam on important organs[J]. Medical Journal of Chinese People’s Liberation Army, 2024 , 49 (10) : 1105 -1109 . DOI: 10.11855/j.issn.0577-7402.0981.2023.1220
Funding
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  • Natural Science Foundation of Guangdong Province(2022A1515012413)
  • Guangdong Medical Science and Technology Research Foundation(B2022294)
  • Scientific Research Project of Traditional Chinese Medicine in Guangdong Province(20191409)
  • Scientific Research Project of Traditional Chinese Medicine in Guangdong Province(20201463)
Appendix
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Year 2024 volume 49 Issue 10
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Article Info
doi: 10.11855/j.issn.0577-7402.0981.2023.1220
  • Receive Date：2023-07-21
  • Online Date：2025-11-20
  • Published：2024-10-28
Article Data
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History
  • Received：2023-07-21
  • Accepted：2023-11-08
Funding
Natural Science Foundation of Guangdong Province(2022A1515012413)
Guangdong Medical Science and Technology Research Foundation(B2022294)
Scientific Research Project of Traditional Chinese Medicine in Guangdong Province(20191409)
Scientific Research Project of Traditional Chinese Medicine in Guangdong Province(20201463)
Affiliations
    1The First Clinical Medical College of Guangdong Medical University, Zhanjiang, Guangdong 524023, China
    2Department of Anesthesiology, Jieyang People's Hospital, Jieyang, Guangdong 522000, China

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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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