Acromegaly can cause chronic complications in multiple systems such as the cardiovascular, respiratory, digestive, and endocrine systems, increasing the risk of death and significantly shortening the patient's life expectancy. Timely screening and early diagnosis and treatment can significantly improve the prognosis of patients and indirectly reflect the level of diagnosis and treatment of hospitals or teams. Clinical communication and research have revealed that physicians, in the course of clinical practice, are frequently constrained by factors such as time, economic considerations, and patient compliance, which hinder their ability to perform comprehensive screening for acromegaly-related complications. This review draws on expert consensuses and guidelines from both domestic and international sources, integrating them with the specific realities of China, to provide a comprehensive summary of the key aspects of screening and management for acromegaly-related complications. These aspects include the incidence of complications, optimal timing for screening, treatment approaches, long-term monitoring, and strict management protocols. It emphasizes standardization, precision, and personalization in clinical diagnosis and treatment work, aiming to comprehensively improve the diagnosis and treatment level of acromegaly in China, enhance the survival rate of patients, and improve their quality of life.