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Advances in nanoparticle drug delivery systems for intervertebral disc degeneration
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Bao-Lin Zhang1, Xue-Xue Li1, Zhi-Zhong Shang1, Ming-Chuan Wang1, Xin Wang1, 2, *
Medical Journal of Chinese People’s Liberation Army | 2025, 50(1) : 101 - 111
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Medical Journal of Chinese People’s Liberation Army | 2025, 50(1): 101-111
• Review •
Advances in nanoparticle drug delivery systems for intervertebral disc degeneration
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Bao-Lin Zhang1, Xue-Xue Li1, Zhi-Zhong Shang1, Ming-Chuan Wang1, Xin Wang1, 2, *
Affiliations
  • 1The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu 730000, China
  • 2Department of Orthopedics, the First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China
Published: 2025-01-28 doi: 10.11855/j.issn.0577-7402.1125.2024.0407
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Intervertebral disc degeneration (IDD) is a prevalent clinical degenerative disease that currently can only be treated through conservative and surgical treatments, which only alleviate symptoms and are not significantly effective. In recent years, nanoparticles have been widely studied in the biomedical field due to their biodegradability, biocompatibility, extended body circulation, sustained and controlled release, and precise drug targeting. Nanoparticle drug delivery systems have the potential to deliver a range of therapeutic agents including proteins, drugs, genes, and cells, thereby promoting tissue and cell repair and regeneration, which offers hope for IDD treatment. However, there are still challenges in translating experimental data into practical therapies applicable to humans. This review summarizes recent research progress on drug delivery systems for IDD treatment based on nanoparticles and provides insights and prospects for the challenges faced by nanoparticles, aiming to provide a reference for the clinical translation of nanoparticle-based treatment for IDD.

intervertebral disc degeneration  /  nanoparticles  /  drug delivery  /  carrier  /  targeting
Bao-Lin Zhang, Xue-Xue Li, Zhi-Zhong Shang, Ming-Chuan Wang, Xin Wang. Advances in nanoparticle drug delivery systems for intervertebral disc degeneration[J]. Medical Journal of Chinese People’s Liberation Army, 2025 , 50 (1) : 101 -111 . DOI: 10.11855/j.issn.0577-7402.1125.2024.0407
Funding
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  • Natural Science Foundation of Gansu Province(21JR7RA362)
  • Gansu Higher Education Youth Doctoral Fund Project(2022QB-007)
  • Intramural Fund of the First Hospital of Lanzhou University(ldyyyn2021-121)
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Year 2025 volume 50 Issue 1
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Article Info
doi: 10.11855/j.issn.0577-7402.1125.2024.0407
  • Receive Date：2023-08-22
  • Online Date：2025-11-10
  • Published：2025-01-28
Article Data
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History
  • Received：2023-08-22
  • Accepted：2023-11-16
Funding
Natural Science Foundation of Gansu Province(21JR7RA362)
Gansu Higher Education Youth Doctoral Fund Project(2022QB-007)
Intramural Fund of the First Hospital of Lanzhou University(ldyyyn2021-121)
Affiliations
    1The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu 730000, China
    2Department of Orthopedics, the First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China

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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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