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Constructive elements and applications of sebaceous gland organoids
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Lu Wu1, 2, Biao Liu1, Li-Xin Weng1, 3, *
Medical Journal of Chinese People’s Liberation Army | 2025, 50(1) : 112 - 120
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Medical Journal of Chinese People’s Liberation Army | 2025, 50(1): 112-120
• Review •
Constructive elements and applications of sebaceous gland organoids
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Lu Wu1, 2, Biao Liu1, Li-Xin Weng1, 3, *
Affiliations
  • 1Basic Medical College, Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China
  • 2Department of Pathology, School of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou, Inner Mongolia 014040, China
  • 3Department of Pathology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China
Published: 2025-01-28 doi: 10.11855/j.issn.0577-7402.1157.2024.0528
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Sebaceous glands are vital appendages of the skin, primarily functioning in the secretion of a variety of lipid substances. These lipid substances play crucial physiological roles in the body, such as participating in body temperature regulation, maintaining skin homeostasis, and modulating the immune system. Abnormalities in the function of sebaceous glands can lead to a range of skin disorders, with acne being the most common one. Acne arises from the overproduction of sebum by sebaceous gland, leading to hair follicle blockage, bacterial infection, and inflammation response. Additionally, sebaceous gland carcinoma is a rare but severe malignant tumor of the skin, and its exact mechanisms are not fully understood. Organoids are closely resemble in vivo counterparts in terms of cell types, spatial structure, and function. Sebaceous gland organoids serve as an ideal platform for studying sebaceous glands and their associated diseases. This review summarizes the structure, function, homeostasis of sebaceous glands, as well as the construction and applications of sebaceous gland organoids, aiming to provide reference for research on the pathogenesis and treatment of sebaceous gland related diseases.

skin  /  sebaceous gland  /  organoid  /  application
Lu Wu, Biao Liu, Li-Xin Weng. Constructive elements and applications of sebaceous gland organoids[J]. Medical Journal of Chinese People’s Liberation Army, 2025 , 50 (1) : 112 -120 . DOI: 10.11855/j.issn.0577-7402.1157.2024.0528
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  • Scientific Research Project of Colleges and Universities in Inner Mongolia Autonomous Region(NJZC17108)
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Year 2025 volume 50 Issue 1
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doi: 10.11855/j.issn.0577-7402.1157.2024.0528
  • Receive Date：2023-08-31
  • Online Date：2025-11-10
  • Published：2025-01-28
Article Data
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History
  • Received：2023-08-31
  • Accepted：2023-10-20
Funding
Scientific Research Project of Colleges and Universities in Inner Mongolia Autonomous Region(NJZC17108)
Affiliations
    1Basic Medical College, Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China
    2Department of Pathology, School of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou, Inner Mongolia 014040, China
    3Department of Pathology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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