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Objective To evaluate the predictive value of dose-surface histogram (DSH) for radiation proctitis (RP) in prostate cancer (PCa) patients undergoing radiotherapy. Methods This prospective randomized controlled clinical trial included 380 PCa patients who underwent image-guided radiotherapy in the First Affiliated Hospital of Hebei Northern University from January 2018 to January 2023. Patients were randomly divided into observation group (n=200) and control group (n=180). The rectal dose distribution of patients in the two groups was evaluated by using DSH and dose-volume histogram (DVH), respectively. The receiver operating characteristic (ROC) curve was utilized to evaluate the predictive value of DSH for acute RP, with DVH serving as a reference. Results The difference was not statistically significant in clinical information such as age, KPS score, and body mass index (BMI) between the observation and control groups (P>0.05), as well as in acute RP incidence (P>0.05). There were significant differences in S40 and V40, S50 and V50, S60 and V60, S70 and V70, and S78 and V78 between the two groups (P<0.05). S40, S50, V40, and V50 showed low efficacy (P<0.001) in predicting acute RP at each level, with AUC ≤0.700. S60 and V60 showed moderate efficacy (P<0.001) in predicting acute RP at each level, with AUC 0.700-0.900. S70, S78, V70 and V78 showed high efficacy (P<0.001) in predicting acute RP at each level, with AUC >0.900. Conclusions The predictive value of DSH for rectal toxicity in patients with PCa is basically consistent with that of DVH. It is expected to become a novel and valuable tool for evaluating radiotherapy plans in the future.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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