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Regulatory mechanisms and therapeutic strategies of microcirculation after spinal cord injury
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Jing Huang1, Ya-Feng Ren2, *, Wen-Ya Shang1, Zhi-Lan Zhang1, Xiao-Meng Huang1, Bing Li2
Medical Journal of Chinese People’s Liberation Army | 2025, 50(3) : 358 - 365
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Medical Journal of Chinese People’s Liberation Army | 2025, 50(3): 358-365
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Regulatory mechanisms and therapeutic strategies of microcirculation after spinal cord injury
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Jing Huang1, Ya-Feng Ren2, *, Wen-Ya Shang1, Zhi-Lan Zhang1, Xiao-Meng Huang1, Bing Li2
Affiliations
  • 1Rehabilitation School of Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China
  • 2Rehabilitation Center of the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450000, China
Published: 2025-03-28 doi: 10.11855/j.issn.0577-7402.1295.2024.0307
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Spinal cord injury (SCI) is a structural and functional disruption of the spinal cord caused by various factors, leading to neurological dysfunction. As a common central nervous system disorder in clinical practice, SCI poses significant risks to human life and health. Its pathological mechanism is exceedingly complex, involving multiple pathological processes. Given the irreversibility of primary injury, targeting secondary injury has gradually become the main direction for the clinical treatment of SCI in recent years. Recent studies have highlighted the crucial role of blood-spinal cord barrier damage and microvascular dysfunction in the progression of secondary injury following SCI. Therefore, investigating the pathological mechanisms of microcirculation and exploring targeted therapies could provide valuable insights for clinical SCI treatment. This paper aims to provide an objective review of the role of microcirculation in SCI, identify the critical regulators of microvascular function, and summarize strategies for treating SCI by targeting microcirculation. The findings of this study may offer novel references for the clinical management of SCI.

spinal cord injury  /  microcirculation  /  blood-spinal cord barrier  /  regulators  /  targeted therapy
Jing Huang, Ya-Feng Ren, Wen-Ya Shang, Zhi-Lan Zhang, Xiao-Meng Huang, Bing Li. Regulatory mechanisms and therapeutic strategies of microcirculation after spinal cord injury[J]. Medical Journal of Chinese People’s Liberation Army, 2025 , 50 (3) : 358 -365 . DOI: 10.11855/j.issn.0577-7402.1295.2024.0307
Funding
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  • Henan Provincial Scientific Research Program on Traditional Chinese Medicine(2022JDZX015)
  • Henan Provincial Scientific Research Program on Traditional Chinese Medicine(2021JDZY022)
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Year 2025 volume 50 Issue 3
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Article Info
doi: 10.11855/j.issn.0577-7402.1295.2024.0307
  • Receive Date：2023-09-25
  • Online Date：2025-11-10
  • Published：2025-03-28
Article Data
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History
  • Received：2023-09-25
  • Accepted：2023-12-01
Funding
Henan Provincial Scientific Research Program on Traditional Chinese Medicine(2022JDZX015)
Henan Provincial Scientific Research Program on Traditional Chinese Medicine(2021JDZY022)
Affiliations
    1Rehabilitation School of Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China
    2Rehabilitation Center of the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450000, China

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