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Research progress on correlation of non-steroidal anti-inflammatory drugs and bone stress injury
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Ning Qiang1, 2, 3, Jin Wang4, Jian Yu1, Jin-Fang Xu5, Ming-Xin Wang6, Chen-Hui Dong1, 2, *, Shen-Song Li1, Jin Zhao2, Chun-Bao Li6
Medical Journal of Chinese People’s Liberation Army | 2025, 50(3) : 341 - 350
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Medical Journal of Chinese People’s Liberation Army | 2025, 50(3): 341-350
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Research progress on correlation of non-steroidal anti-inflammatory drugs and bone stress injury
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Ning Qiang1, 2, 3, Jin Wang4, Jian Yu1, Jin-Fang Xu5, Ming-Xin Wang6, Chen-Hui Dong1, 2, *, Shen-Song Li1, Jin Zhao2, Chun-Bao Li6
Affiliations
  • 1Department of Sports Medicine, the 940th Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, Gansu 730050, China
  • 2Department of Medical Centre, Northwest Minzu University, Lanzhou, Gansu 730030, China
  • 3Department of Orthopedics, Yongning People's Hospital, Yinchuan, Ningxia 750100, China
  • 4Department of Traditional Chinese Medicine Rehabilitation, the 940th Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, Gansu 730050, China
  • 5Department of Military Health Statistics, Naval Medical University, Shanghai 200433, China
  • 6Department of Orthopedics, the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Published: 2025-03-28 doi: 10.11855/j.issn.0577-7402.0447.2024.0730
Outline
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Non-steroidal anti-inflammatory drugs (NSAIDs), commonly utilized analgesics, are extensively employed for managing pain associated with musculoskeletal disorders or injuries. Recent clinical studies have demonstrated a heightened risk of bone stress injuries (BSI) in soldiers and athletes, particularly during high-intensity training, due to NSAID usage. Furthermore, the impact of NSAIDs on fracture healing is well-documented; however, the precise mechanism by which their use during training contributes to an increased incidence of stress bone injuries remains unclear. This article aims to summarize potential mechanisms through an extensive review of domestic and international literature in order to standardize the utilization and clinical management of NSAIDs, optimize pain management strategies, and prevent stress bone injuries or fractures in specific populations such as soldiers and elite athletes.

non-steroidal anti-inflammatory drugs  /  bone stress injuries  /  bone metabolism  /  prostaglandin  /  osteocyte
Ning Qiang, Jin Wang, Jian Yu, Jin-Fang Xu, Ming-Xin Wang, Chen-Hui Dong, Shen-Song Li, Jin Zhao, Chun-Bao Li. Research progress on correlation of non-steroidal anti-inflammatory drugs and bone stress injury[J]. Medical Journal of Chinese People’s Liberation Army, 2025 , 50 (3) : 341 -350 . DOI: 10.11855/j.issn.0577-7402.0447.2024.0730
Funding
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  • Military Logistics Research Project(CLB21J035)
  • Military Medical Scientific Research Project(2021YXKY020)
  • Fundamental Research Funds for the Central Universities of MCF Project(31920220108)
Appendix
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Year 2025 volume 50 Issue 3
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263
117
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Article Info
doi: 10.11855/j.issn.0577-7402.0447.2024.0730
  • Receive Date：2024-04-08
  • Online Date：2025-11-10
  • Published：2025-03-28
Article Data
Affiliations
History
  • Received：2024-04-08
  • Accepted：2024-06-10
Funding
Military Logistics Research Project(CLB21J035)
Military Medical Scientific Research Project(2021YXKY020)
Fundamental Research Funds for the Central Universities of MCF Project(31920220108)
Affiliations
    1Department of Sports Medicine, the 940th Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, Gansu 730050, China
    2Department of Medical Centre, Northwest Minzu University, Lanzhou, Gansu 730030, China
    3Department of Orthopedics, Yongning People's Hospital, Yinchuan, Ningxia 750100, China
    4Department of Traditional Chinese Medicine Rehabilitation, the 940th Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, Gansu 730050, China
    5Department of Military Health Statistics, Naval Medical University, Shanghai 200433, China
    6Department of Orthopedics, the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100853, China

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栓菌属 Trametes 5 2.39
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