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Association between intestinal flora and secondary resistance to imatinib in gastrointestinal stromal tumors
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Hao-Lin Li1, 2, 3, Shu Wang1, 2, Yan Zhao1, 2, Jian-Jun Yang1, 2, *
Medical Journal of Chinese People’s Liberation Army | 2025, 50(3) : 277 - 283
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Medical Journal of Chinese People’s Liberation Army | 2025, 50(3): 277-283
• Special Issue on Role of Gut Microbiota in Disease Occurrence and Treatment •
Association between intestinal flora and secondary resistance to imatinib in gastrointestinal stromal tumors
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Hao-Lin Li1, 2, 3, Shu Wang1, 2, Yan Zhao1, 2, Jian-Jun Yang1, 2, *
Affiliations
  • 1Department of Digestive Surgery, the First Affiliated Hospital of Air Force Medical University/Xijing Hospital of Digestive Diseases, Xi'an, Shaanxi 710032, China
  • 2State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, Shaanxi 710032, China
  • 3The Fifth Cadet Brigade of School of Basic Medicine, Air Force Medical University, Xi'an, Shaanxi 710032, China
Published: 2025-03-28 doi: 10.11855/j.issn.0577-7402.0056.2024.0620
Outline
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Gastrointestinal stromal tumor (GIST) is the most prevalent mesenchymal tumor of the gastrointestinal tract, with imatinib serving as the first-line drug for metastatic GIST due to its good clinical efficacy. However, the majority of patients exhibit tumor progression within several years of drug therapy, primarily due to the high rate of drug resistance, which significantly impedes drug therapeutic outcome and patient prognosis. Traditional approaches to counteract resistance, including dosage increase and subsequent line therapy yielded suboptimal results. As a research hotspot, intestinal flora has been proven to be closely related to drug resistance of various tumors. In recent years, it has been observed that specific intestinal flora could serve as biomarkers for early GIST patient screening or as potential drug targets, and modulating the intestinal flora through interventions may delay or even reverse the progression of imatinib secondary drug resistance in GIST. This review delineates the drug resistance of GIST, correlations between intestinal flora and drug resistance of tumors, as well as the relationship between intestinal flora and drug resistance of GIST, aiming to provide novel perspectives and methodologies for clinical application.

gastrointestinal stromal tumor  /  gastrointestinal microbiome  /  imatinib mesylate  /  drug resistance
Hao-Lin Li, Shu Wang, Yan Zhao, Jian-Jun Yang. Association between intestinal flora and secondary resistance to imatinib in gastrointestinal stromal tumors[J]. Medical Journal of Chinese People’s Liberation Army, 2025 , 50 (3) : 277 -283 . DOI: 10.11855/j.issn.0577-7402.0056.2024.0620
Funding
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  • Key Research and Development Project of Shaanxi Province(2022ZDLSF03-04)
  • Innovative Exploratory Project of the State Key Laboratory of Tumor Biology(CBSKL2022ZZ41)
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Year 2025 volume 50 Issue 3
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Article Info
doi: 10.11855/j.issn.0577-7402.0056.2024.0620
  • Receive Date：2024-01-14
  • Online Date：2025-11-10
  • Published：2025-03-28
Article Data
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History
  • Received：2024-01-14
  • Accepted：2024-04-12
Funding
Key Research and Development Project of Shaanxi Province(2022ZDLSF03-04)
Innovative Exploratory Project of the State Key Laboratory of Tumor Biology(CBSKL2022ZZ41)
Affiliations
    1Department of Digestive Surgery, the First Affiliated Hospital of Air Force Medical University/Xijing Hospital of Digestive Diseases, Xi'an, Shaanxi 710032, China
    2State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, Shaanxi 710032, China
    3The Fifth Cadet Brigade of School of Basic Medicine, Air Force Medical University, Xi'an, Shaanxi 710032, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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