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The research progress on the correlation between gut microbiota and Graves' ophthalmopathy
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Yue-Ying Li, Shan-Si Yuan, Yang Wang, Kai-Jun Li*
Medical Journal of Chinese People’s Liberation Army | 2025, 50(3) : 269 - 276
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Medical Journal of Chinese People’s Liberation Army | 2025, 50(3): 269-276
• Special Issue on Role of Gut Microbiota in Disease Occurrence and Treatment •
The research progress on the correlation between gut microbiota and Graves' ophthalmopathy
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Yue-Ying Li, Shan-Si Yuan, Yang Wang, Kai-Jun Li*
Affiliations
  • Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China
Published: 2025-03-28 doi: 10.11855/j.issn.0577-7402.0931.2024.0328
Outline
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Graves' ophthalmopathy (GO) is a specific autoimmune disease occurring in orbital tissues and is closely related to hyperthyroidism caused by Graves' disease (GD). Its disabling and disfiguring features significantly impact the quality of life of patients. The exact mechanism of GO still remains to be fully elucidated. In recent years, gene sequencing and medical microbiology studies have shown that changes in the gut microbiota may play a role in the development and progression of GO, with gut dysbiosis altering immune system regulatory signals and causing immune damage to organs. Clarifying the correlation between gut microbiota and GO helps to understand the disease's pathogenic mechanism and provides a theoretical basis for the diagnosis and treatment of GO. This review summarizes the impact of gut microbiota dysbiosis in the pathogenesis of GO and promising therapeutic approaches, including research progress in aspects such as gut microbiota experiments, case studies, pathogenesis, and treatment strategies.

Graves' ophthalmopathy  /  gut microbiota  /  pathogenesis  /  treatment
Yue-Ying Li, Shan-Si Yuan, Yang Wang, Kai-Jun Li. The research progress on the correlation between gut microbiota and Graves' ophthalmopathy[J]. Medical Journal of Chinese People’s Liberation Army, 2025 , 50 (3) : 269 -276 . DOI: 10.11855/j.issn.0577-7402.0931.2024.0328
Funding
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  • National Natural Science Foundation of China(82160206)
  • Guangxi Natural Science Foundation(2018GXNSFAA281234)
Appendix
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Year 2025 volume 50 Issue 3
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Article Info
doi: 10.11855/j.issn.0577-7402.0931.2024.0328
  • Receive Date：2023-07-05
  • Online Date：2025-11-10
  • Published：2025-03-28
Article Data
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History
  • Received：2023-07-05
  • Accepted：2023-12-28
Funding
National Natural Science Foundation of China(82160206)
Guangxi Natural Science Foundation(2018GXNSFAA281234)
Affiliations
    Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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