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Research progress on AMPK signaling pathway in the regulation and treatment of spinal cord injury
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Zhi-Lan Zhang1, Xiao-Meng Huang2, Wen-Ya Shang2, Jing Huang2, Hui-Lin Wei2, Bing Li2, Ya-Feng Ren3, *
Medical Journal of Chinese People’s Liberation Army | 2025, 50(4) : 495 - 503
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Medical Journal of Chinese People’s Liberation Army | 2025, 50(4): 495-503
• Review •
Research progress on AMPK signaling pathway in the regulation and treatment of spinal cord injury
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Zhi-Lan Zhang1, Xiao-Meng Huang2, Wen-Ya Shang2, Jing Huang2, Hui-Lin Wei2, Bing Li2, Ya-Feng Ren3, *
Affiliations
  • 1Department of Pediatric Rehabilitation Medicine, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450015, China
  • 2Rehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China
  • 3Rehabilitation Center, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450000, China
Published: 2025-04-28 doi: 10.11855/j.issn.0577-7402.0224.2024.0827
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Spinal cord injury (SCI) is a central nervous system disease with high morbidity and disability rates, bringing serious economic and psychological burdens to families and society worldwide. AMP-activated protein kinase (AMPK) is an important sensor in the energy metabolism process in living organisms, which plays a central role in maintaining energy balance. It is currently considered a key target for the prevention and treatment of multiple diseases. Studies have shown that AMPK signaling can regulate autophagy, neuroinflammation, oxidative stress, mitochondrial function and other processes after SCI, thus affecting the pathological process of SCI. This review summarizes the research progress on AMPK signaling pathway involved in the regulation of SCI, in order to provide new ideas for the treatment and drug development of SCI.

spinal cord injury  /  AMP-activated protein kinase  /  pathological mechanism  /  neuroinflammation  /  axon regeneration
Zhi-Lan Zhang, Xiao-Meng Huang, Wen-Ya Shang, Jing Huang, Hui-Lin Wei, Bing Li, Ya-Feng Ren. Research progress on AMPK signaling pathway in the regulation and treatment of spinal cord injury[J]. Medical Journal of Chinese People’s Liberation Army, 2025 , 50 (4) : 495 -503 . DOI: 10.11855/j.issn.0577-7402.0224.2024.0827
Funding
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  • Special Project for Scientific Research of Traditional Chinese Medicine in Henan Province(2022JDZX015)
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Year 2025 volume 50 Issue 4
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Article Info
doi: 10.11855/j.issn.0577-7402.0224.2024.0827
  • Receive Date：2024-02-24
  • Online Date：2025-10-30
  • Published：2025-04-28
Article Data
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History
  • Received：2024-02-24
  • Accepted：2024-04-12
Funding
Special Project for Scientific Research of Traditional Chinese Medicine in Henan Province(2022JDZX015)
Affiliations
    1Department of Pediatric Rehabilitation Medicine, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450015, China
    2Rehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China
    3Rehabilitation Center, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450000, China

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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
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小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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