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Value of the new WHO pathological classification of pituitary tumors in diagnosis and treatment of clinically non-functioning pituitary adenomas
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Tian Sun1, 2, Xue-Dong Zhang1, Er-Han Zheng3, Hao Shen4, Tao Zhou4, Xiang-Hui Meng4, Qing-Hua Guo1, *
Medical Journal of Chinese People’s Liberation Army | 2025, 50(4) : 387 - 392
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Medical Journal of Chinese People’s Liberation Army | 2025, 50(4): 387-392
• Expert Review •
Value of the new WHO pathological classification of pituitary tumors in diagnosis and treatment of clinically non-functioning pituitary adenomas
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Tian Sun1, 2, Xue-Dong Zhang1, Er-Han Zheng3, Hao Shen4, Tao Zhou4, Xiang-Hui Meng4, Qing-Hua Guo1, *
Affiliations
  • 1Department of Endocrinology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  • 2Department of Endocrinology, No.215 Hospital of Shaanxi Nuclear Industry, Xianyang, Shaanxi 712000, China
  • 3School of Basic Sciences, Capital Medical University, Beijing 100069, China
  • 4Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Published: 2025-04-28 doi: 10.11855/j.issn.0577-7402.1810.2025.0304
Outline
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Non-functioning pituitary adenomas (NFPAs) are relatively common. Apart from hyperprolactinemia caused by pituitary compression, they typically lack overt hormonal hypersecretion and usually present with clinical symptoms due to mass effects. Previously considered a uniform entity, NFPAs are actually a highly heterogeneous group of tumors, including aggressive subtypes like silent corticotroph adenomas (SCA) and null cell adenomas. The 2022 WHO new classification of pituitary tumors employs transcription factors [e.‍g., pituitary-specific transcription factor 1 (PIT-1), T-box transcription factor 19 (TBX19, also known as TPIT), steroidogenic factor 1 (SF-1)] for detailed categorization, allowing precise subclassification of NFPAs into multiple subtypes derived from distinct cell lineages, including silent gonadotroph adenomas, SCA, and plurihormonal PIT-1-positive adenomas. This helps identify highly invasive subtypes with high recurrence risk, guiding clinical diagnosis and treatment, prognostic assessment, and individualized management. The new classification also provides a theoretical basis for targeted therapies of NFPAs (e.g., somatostatin analogs and temozolomide). This review comprehensively discusses the latest pathological classification of NFPAs and its clinical implications, aiming to enhance understanding of this disease and offer valuable insights for precise diagnosis, treatment, and prognostic assessment.

non-functioning pituitary tumor  /  pathological classification  /  transcription factors  /  diagnosis  /  treatment
Tian Sun, Xue-Dong Zhang, Er-Han Zheng, Hao Shen, Tao Zhou, Xiang-Hui Meng, Qing-Hua Guo. Value of the new WHO pathological classification of pituitary tumors in diagnosis and treatment of clinically non-functioning pituitary adenomas[J]. Medical Journal of Chinese People’s Liberation Army, 2025 , 50 (4) : 387 -392 . DOI: 10.11855/j.issn.0577-7402.1810.2025.0304
Funding
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  • National Natural Science Foundation of China(82270824)
  • Beijing Natural Science Foundation(7232153)
  • Capital Health Development Research Special Fund(2024-2-5025)
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Year 2025 volume 50 Issue 4
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Article Info
doi: 10.11855/j.issn.0577-7402.1810.2025.0304
  • Receive Date：2024-11-11
  • Online Date：2025-10-30
  • Published：2025-04-28
Article Data
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History
  • Received：2024-11-11
  • Accepted：2024-12-16
Funding
National Natural Science Foundation of China(82270824)
Beijing Natural Science Foundation(7232153)
Capital Health Development Research Special Fund(2024-2-5025)
Affiliations
    1Department of Endocrinology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
    2Department of Endocrinology, No.215 Hospital of Shaanxi Nuclear Industry, Xianyang, Shaanxi 712000, China
    3School of Basic Sciences, Capital Medical University, Beijing 100069, China
    4Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

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表12种不同金属材料的力学参数
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Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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