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Research progress on inflammatory status and targeted microbiota intervention strategies in chronic kidney disease
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Shao-Jie Kou1, Xin Li2, Fen-Ping Li1, Xiao-Yong Yu1, Xiao-Lin Bai2, *
Medical Journal of Chinese People’s Liberation Army | 2025, 50(5) : 619 - 631
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Medical Journal of Chinese People’s Liberation Army | 2025, 50(5): 619-631
• Review •
Research progress on inflammatory status and targeted microbiota intervention strategies in chronic kidney disease
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Shao-Jie Kou1, Xin Li2, Fen-Ping Li1, Xiao-Yong Yu1, Xiao-Lin Bai2, *
Affiliations
  • 1Department of Hepatology, Hospital of Shaanxi Provincial of TCM, Xi'an, Shaanxi 710003, China
  • 2Department of Endocrinology, Xi'an Hospital of TCM, Xi'an, Shaanxi 710021, China
Published: 2025-05-28 doi: 10.11855/j.issn.0577-7402.1378.2024.1218
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The inflammatory status in patients with chronic kidney disease (CKD) is closely associated with cardiovascular events, infections, and other complications, and is a powerful indicator for prognosis assessment. The core view of the "gut-kidney axis" theory reveals the relationship among inflammatory state, microbiota dysbiosis, and deterioration of renal function. The microbiota alters the microenvironment through structural changes and metabolites with different properties, subsequently leading to microbiota translocation, inducing inflammatory lesions, and damaging the kidneys. Recent studies have proposed that targeted microbiota intervention strategies such as probiotics, prebiotics, and synbiotics can modulate the microbiota structure, regulate the microenvironment, relieve renal inflammation, and affect the progression of renal disease, representing a potentially promising research direction in the future. This review discusses the characteristics of how intestinal microbiota influence the inflammatory status in CKD, focusing on the research progress of targeted microbiota intervention, aiming to discuss the effectiveness and scientific basis of these strategies, providing a foundation for the treatment of CKD and the expansion of targeted microbiota research, as well as offering references for the clinical application of probiotics, prebiotics, and synbiotics.

chronic kidney disease  /  inflammation  /  probiotics  /  prebiotics  /  synbiotics
Shao-Jie Kou, Xin Li, Fen-Ping Li, Xiao-Yong Yu, Xiao-Lin Bai. Research progress on inflammatory status and targeted microbiota intervention strategies in chronic kidney disease[J]. Medical Journal of Chinese People’s Liberation Army, 2025 , 50 (5) : 619 -631 . DOI: 10.11855/j.issn.0577-7402.1378.2024.1218
Funding
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  • Shaanxi Province TCM Academic School Inheritance Studio Construction Project ([2018] No. 40)
  • 2024 Scientific Research Capacity Improvement Project of Municipal TCM Hospital(SZY-NLTL-2024-18)
  • Project of Integration of Chinese and Western Medicine of Clinical Medicine Research Center for Infectious Disease of Shaanxi Province(2020LCZX-02)
  • 2018 National TCM Administration Regional TCM (Liver Disease) Treatment Center Incubation Unit ([2017] No. 39)
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Year 2025 volume 50 Issue 5
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196
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Article Info
doi: 10.11855/j.issn.0577-7402.1378.2024.1218
  • Receive Date：2023-10-23
  • Online Date：2025-10-29
  • Published：2025-05-28
Article Data
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History
  • Received：2023-10-23
  • Accepted：2024-07-19
Funding
Shaanxi Province TCM Academic School Inheritance Studio Construction Project ([2018] No. 40)
2024 Scientific Research Capacity Improvement Project of Municipal TCM Hospital(SZY-NLTL-2024-18)
Project of Integration of Chinese and Western Medicine of Clinical Medicine Research Center for Infectious Disease of Shaanxi Province(2020LCZX-02)
2018 National TCM Administration Regional TCM (Liver Disease) Treatment Center Incubation Unit ([2017] No. 39)
Affiliations
    1Department of Hepatology, Hospital of Shaanxi Provincial of TCM, Xi'an, Shaanxi 710003, China
    2Department of Endocrinology, Xi'an Hospital of TCM, Xi'an, Shaanxi 710021, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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