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Advances in research of pathophysiological mechanisms and diagnosis of Alzheimer's disease
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Ya-Nan Wang1, Ling Ren1, Wei Han2, Bin Sun2, 3, *
Medical Journal of Chinese People’s Liberation Army | 2025, 50(5) : 632 - 640
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Medical Journal of Chinese People’s Liberation Army | 2025, 50(5): 632-640
• Review •
Advances in research of pathophysiological mechanisms and diagnosis of Alzheimer's disease
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Ya-Nan Wang1, Ling Ren1, Wei Han2, Bin Sun2, 3, *
Affiliations
  • 1Department of Nuclear Medicine, Capital Medical University Electric Power Teaching Hospital/State Grid Beijing Electric Power Hospital, Beijing 100073, China
  • 2Shenzhen Runming Biotech Co. Ltd., Shenzhen, Guangdong 518063, China
  • 3China Resources Pharmaceutical Commercial Medical Device Research Institute, Beijing 100009, China
Published: 2025-05-28 doi: 10.11855/j.issn.0577-7402.0467.2024.0913
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Alzheimer's disease (AD), a major cause of dementia, is a common neurodegenerative disease, beginning with memory loss and difficulties with thinking, language and problem-solving skills. Intensification of population aging and the increasing incidence of AD have imposed a heavy burden on healthcare systems. Currently, the main pathological explanation remains the excessive accumulation of β‑amyloid plaques, formation of neurofibrillary tangles and neuronal loss, but the true etiology and pathogenesis of AD remain unknown. The advances of research in AD, with respect to genetics, pathophysiological mechanism, imaging diagnosis and laboratory diagnosis, are reviewed in this article, aiming to provide references for relevant research and potential clinical applications.

Alzheimer's disease  /  cognitive impairment  /  imaging diagnosis  /  biomarkers
Ya-Nan Wang, Ling Ren, Wei Han, Bin Sun. Advances in research of pathophysiological mechanisms and diagnosis of Alzheimer's disease[J]. Medical Journal of Chinese People’s Liberation Army, 2025 , 50 (5) : 632 -640 . DOI: 10.11855/j.issn.0577-7402.0467.2024.0913
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Year 2025 volume 50 Issue 5
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Article Info
doi: 10.11855/j.issn.0577-7402.0467.2024.0913
  • Receive Date：2024-04-10
  • Online Date：2025-10-29
  • Published：2025-05-28
Article Data
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History
  • Received：2024-04-10
  • Accepted：2024-05-28
Affiliations
    1Department of Nuclear Medicine, Capital Medical University Electric Power Teaching Hospital/State Grid Beijing Electric Power Hospital, Beijing 100073, China
    2Shenzhen Runming Biotech Co. Ltd., Shenzhen, Guangdong 518063, China
    3China Resources Pharmaceutical Commercial Medical Device Research Institute, Beijing 100009, China

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