Article(id=1322931697209189344, tenantId=1146029695717560320, journalId=1220038315760373764, issueId=1322931549481599694, articleNumber=null, orderNo=null, doi=10.12102/j.issn.1009-6493.2026.12.024, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1747843200000, receivedDateStr=2025-05-22, revisedDate=1779552000000, revisedDateStr=2026-05-24, acceptedDate=null, acceptedDateStr=null, onlineDate=1793341095497, onlineDateStr=2026-10-30, pubDate=1782316800000, pubDateStr=2026-06-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793341095497, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793341095497, creator=13701087609, updateTime=1793341095497, updator=13701087609, issue=Issue{id=1322931549481599694, tenantId=1146029695717560320, journalId=1220038315760373764, year='2026', volume='40', issue='12', pageStart='2001', pageEnd='2192', issueExtLink='null', onlineDate='null', pubDate='1782316800000', pubDateStr='2026-06-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793341060276, creator='13701087609', updateTime=1793343118019, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322940180335829530, tenantId=1146029695717560320, journalId=1220038315760373764, issueId=1322931549481599694, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322940180335829531, tenantId=1146029695717560320, journalId=1220038315760373764, issueId=1322931549481599694, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2174, endPage=2179, ext={EN=ArticleExt(id=1322931697414710241, articleId=1322931697209189344, tenantId=1146029695717560320, journalId=1220038315760373764, language=EN, title=Application progress on time-restricted eating in breast cancer patients, columnId=1220689485315101342, journalTitle=Chinese Nursing Research, columnName=Review Articles, runingTitle=null, highlight=null, articleAbstract=

This paper summarized the concept of time-restricted eating(TRE).It reviewed its mechanism and application effects in breast cancer patients,and explored the potential of TRE and combination therapy,so as to provide the reference for the intervention treatment of breast cancer through TRE.

, authors=Xuan LIU, Chongqing SHI, authorsList=Xuan LIU, Chongqing SHI, authorCompany=null, correspAuthors=Chongqing SHI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322931697704117218, articleId=1322931697209189344, tenantId=1146029695717560320, journalId=1220038315760373764, language=CN, title=限时饮食在乳腺癌病人中的应用进展, columnId=1220689485482873504, journalTitle=护理研究, columnName=科研综述, runingTitle=null, highlight=null, articleAbstract=

总结限时饮食的概念,综述限时饮食在乳腺癌病人中的作用机制及应用效果,提出限时饮食与联合治疗的潜力,以期为限时饮食干预治疗乳腺癌提供参考。

, authors=刘旋, 史崇清*, *, authorsList=刘旋, 史崇清, authorCompany=null, correspAuthors=史崇清, authorNote=

刘旋,硕士研究生

, correspAuthorsNote=
史崇清,E-mail:
SHI Chongqing, E-mail:
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刘旋,硕士研究生

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刘旋,硕士研究生

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限时饮食在乳腺癌病人中的应用进展
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刘旋 , 史崇清 *, *
护理研究 | 科研综述 2026,40(12): 2174-2179
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护理研究 |科研综述 2026 , 40 (12) : 2174 -2179
限时饮食在乳腺癌病人中的应用进展
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刘旋,硕士研究生

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刘旋,硕士研究生

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刘旋, 史崇清*, *
作者信息
  • 1武汉科技大学医学院,湖北 430065
通讯作者:
史崇清,E-mail:
SHI Chongqing, E-mail:
作者简介:

刘旋,硕士研究生

Application progress on time-restricted eating in breast cancer patients
Xuan LIU, Chongqing SHI
Affiliations
  • 1School of Medicine, Wuhan University of Science and Technology, Hubei 430065 China
出版时间: 2026-06-25 doi: 10.12102/j.issn.1009-6493.2026.12.024
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总结限时饮食的概念,综述限时饮食在乳腺癌病人中的作用机制及应用效果,提出限时饮食与联合治疗的潜力,以期为限时饮食干预治疗乳腺癌提供参考。

乳腺癌  /  限时饮食  /  饮食干预  /  联合治疗  /  综述

This paper summarized the concept of time-restricted eating(TRE).It reviewed its mechanism and application effects in breast cancer patients,and explored the potential of TRE and combination therapy,so as to provide the reference for the intervention treatment of breast cancer through TRE.

breast cancer  /  time-restricted eating, TRE  /  dietary intervention  /  combination therapy  /  review
刘旋, 史崇清. 限时饮食在乳腺癌病人中的应用进展. 护理研究, 2026 , 40 (12) : 2174 -2179 . DOI: 10.12102/j.issn.1009-6493.2026.12.024
Xuan LIU, Chongqing SHI. Application progress on time-restricted eating in breast cancer patients[J]. Chinese Nursing Research, 2026 , 40 (12) : 2174 -2179 . DOI: 10.12102/j.issn.1009-6493.2026.12.024
2022年,全球估计有约230万例女性乳腺癌新发病例,占全球女性癌症病例的11.6%,是女性中最常见的癌症[1]。随着人口老龄化,预计未来我国和全球乳腺癌的疾病负担将持续增加[2]。目前,乳腺癌治疗虽已显著提高5年生存率,但同时也给病人的生活质量和预后带来了较大的影响[3]。随着研究的深入,饮食摄入干预在改善病人的生活质量和治疗效果方面显示出显著的潜在价值。学者一直在关注饮食对于癌症控制的作用与影响,但目前的饮食建议主要集中在食物和营养素的种类及数量方面[4],关于饮食时间(如进食频率、进食时段等)对癌症控制的潜在影响,目前的研究仍相对有限。近年来,限时饮食(time-restricted eating,TRE)作为一种新兴的饮食干预策略,在乳腺癌的治疗及预后中逐渐展现出一定的积极作用。鉴于此,本研究综述了限时饮食在乳腺癌领域应用的研究进展,旨在为未来乳腺癌的临床治疗提供有益参考。
限时饮食是一种将参与者的进食时间限制在特定时间段内(6~12 h)的饮食干预方法,不限制摄入的种类和能量[5],是间歇性禁食(intermittent fasting,IF)中的一种方法,通常采用16∶8模式,即8 h进食窗口和16 h禁食方式[6]。目前限时饮食在临床试验中表现出了明显的健康益处,包括减轻体重、改善代谢健康以及提高生活质量等。
研究发现,高胰岛素血症和胰岛素抵抗是乳腺癌的潜在驱动因素[7-8]。胰岛素与胰岛素受体结合后,经磷脂酰肌醇 3 激酶和丝裂原活化蛋白激酶等信号通路,刺激乳腺癌细胞增殖、迁移和侵袭。同时,胰岛素还能调节脂肪细胞分泌瘦素、脂联素,调控雌激素产生,刺激血管生成,这些机制相互交织,共同促进乳腺癌的发生发展[7]。胰岛素主要是在进食后分泌,Das等[5]研究中将小鼠饮食时间限制在夜间8 h内,小鼠体重先快速下降,随后胰岛素抵抗延迟改善。限时饮食能减少肝脏脂肪变性,降低肝脏脂质滴数量和大小,下调促进脂肪堆积的脂质转运和储存基因表达。此外,限时饮食降低乳腺和内脏脂肪量,减少乳腺脂肪垫中巨噬细胞冠状结构数量,降低炎症基因表达,减少因脂肪堆积产生的游离脂肪酸,优化胰岛素作用环境,改善胰岛素抵抗。在调节相关信号通路方面,限时饮食降低丝氨酸/苏氨酸蛋白激酶和糖原合成酶激酶-3β的磷酸化水平。由于该通路在细胞增殖、存活和代谢中至关重要,限时饮食对其调节影响与胰岛素抵抗相关的细胞代谢过程,进一步提高胰岛素敏感性,降低胰岛素抵抗,最终抑制乳腺癌细胞的增殖分化,降低乳腺癌发生风险。
此外,高血糖也是促进乳腺癌细胞增殖分化的重要影响因素之一[9-10]。在高血糖环境下,生长在纤连蛋白上的乳腺癌细胞会发生上皮间质转化,导致细胞黏附性降低,迁移和侵袭能力增强,同时还能促进乳腺癌细胞的增殖和生长,增强无氧糖酵解代谢[9]。并且高血糖还会通过多种机制导致乳腺癌细胞对化疗药物产生耐药性,包括抑制细胞凋亡、改变肿瘤微环境、影响药物转运、改变信号通路以及增强DNA损伤修复能力等[10]。
限时饮食主要通过减少每日进食时间、延长禁食时间实现对血糖的调节。这一过程能够减少胰岛素的分泌总量,降低胰岛素抵抗指数,有效改善胰岛素敏感性。同时,限时饮食还能改善胰岛素信号传导,进一步减弱胰岛素抵抗,使细胞对葡萄糖的摄取和利用效率得以提高。此外,限时饮食缩短了餐间间隔,减少了血糖和胰岛素水平上升之间的滞后时间,从而有助于降低体内整体血糖水平[11-12]。在禁食期间,身体的能量代谢方式发生改变。由于葡萄糖摄入减少,细胞会通过氧化脂肪酸来产生能量,同时增加酮体的生成。酮体作为一种替代能量来源,能够减少细胞对葡萄糖的需求,进而降低血糖水平。而且,酮体还具有促进细胞差异应激抵抗力的作用,有助于增强细胞在不利环境中的生存能力[13]。Das等[5]以小鼠为研究对象进行随机对照实验。实验将小鼠分为自由进食组(AL)、限时饮食组(限时饮食)和正常饮食组(NC)。研究显示,限时饮食 组的空腹血浆胰岛素水平、胰岛素抵抗稳态模型评估值以及葡萄糖水平均有所降低,同时,在禁食期间,该组小鼠的酮体水平升高,血糖水平降低。这一系列变化表明,限时饮食改善小鼠的胰岛素敏感性,降低血糖,对抑制乳腺癌细胞产生积极作用[5]。另外,一项针对2 413例早期乳腺癌非糖尿病病人的前瞻性研究发现,习惯性夜间禁食时长与糖化血红蛋白(HbA1c)呈负相关[14]。这意味着较长的夜间禁食时长与较低的HbA1c水平密切相关,充分说明延长夜间禁食有助于改善血糖调节,降低乳腺癌的复发风险。以上说明限时饮食通过调节代谢过程,增强胰岛素敏感性,降低血糖水平,进而减少乳腺癌细胞微环境中的能量供应,对乳腺癌细胞的增殖起到抑制作用。
一般情况下,正常乳腺细胞存在功能性时钟,通过核心生物钟基因及其调控的蛋白质,形成一个复杂的反馈回路,导致细胞周期、代谢、DNA修复等过程的昼夜节律,其破坏会导致乳腺细胞异常生长,从而导致乳腺癌[15]。研究发现,改善肿瘤昼夜节律的治疗可减缓细胞周期进程并减少增殖和肿瘤生长[16]。在一项小鼠模型实验中,研究人员对小鼠进行每天6~8 h的限时饮食处理,并检测肝脏、乳腺脂肪垫和肿瘤组织中时钟基因的表达,结果发现,限时饮食具有多方面的积极作用,在肝脏中,它能够增强昼夜节律,使多个关键基因的节律得以恢复或改善,相关蛋白的昼夜节律振荡也更加明显;对于乳腺脂肪垫,限时饮食可调节其昼夜节律,恢复部分基因的正常节律,并影响相关蛋白的表达;在肿瘤组织方面,限时饮食能够恢复昼夜节律,改善关键基因的表达和节律,促使相关蛋白的昼夜节律更趋近于正常组织水平,进而抑制乳腺癌的生长[5]。此外,Walker等[17]也开展了小鼠实验,该实验选取45只小鼠,先让其在12 h光照周期下适应性饲养1周,随后对小鼠注射乳腺癌细胞,并将其分为3组,分别为活跃期进食组(在小鼠非光照期间进食)、非活跃期进食组(在光照期间进食)和自由进食组,实验持续23 d,鉴于小鼠具有夜行性特点,在非活跃期进食会破坏其昼夜节律;实验结果显示,活跃期进食组的肿瘤生长效率最低。进一步表明限时饮食可通过改善昼夜节律,有效降低乳腺癌的生长效率。可见,限时饮食能够通过调节生物钟,恢复细胞的昼夜节律,从而对乳腺癌的发展起到抑制作用。
细胞和动物模型的研究表明,在禁食期间,细胞的能量来源从葡萄糖转向脂肪酸和酮体,这种代谢转换触发了细胞的自噬,这一种细胞内降解和循环机制,通过将细胞内物质运输到溶酶体进行降解,从而维持细胞内稳态和细胞存活[18]。Debnath等[19]描述限时饮食通过多种机制促进细胞自噬,包括激活AMP信号通路、抑制mTORC1信号通路、上调自噬相关基因、调节代谢和能量应激、清除受损细胞器和蛋白质以及增强免疫细胞功能,进而促进自噬体的形成,增强免疫细胞的功能,从而共同抑制肿瘤细胞的生长。Jamshed等[11]研究发现,限时饮食能够显著上调自噬基因LC3A的表达(在早晨增加了22%),可以减少细胞内的氧化应激和炎症反应。目前在乳腺癌病人中限时饮食在细胞自噬上研究有限,未来需要进一步加深研究。
与其他癌症相比,乳腺癌病人在治疗期间体重增加的现象更为普遍,相关数据显示,50%~96%的病人在治疗过程中会出现体重上升情况[20]。此外,成人体质指数与乳腺癌的发病风险呈正相关[21],即体质指数升高往往伴随着乳腺癌发病风险上升,肥胖与乳腺癌之间存在密切的关联性[22]。因此,体重管理对于乳腺癌病人的治疗效果和预后具有重要意义。一项涉及48 835例乳腺癌病人的随机对照试验表明,控制体重有助于降低癌症死亡率,提高生存率[23]。这表明降低病人的体重、改善其代谢状态与降低合并症风险以及更好的治疗结果密切相关。在动物实验方面,限时饮食也显示出积极的效果。一项小鼠实验中,与自由进食组的小鼠相比,限时饮食组的肝脂滴数量和大小以及乳腺脂肪垫中巨噬细胞冠状结构的数量均显著减少。这说明限时饮食在不改变食物摄入量的情况下,能够减少肝脏脂肪沉积,改善肝脏代谢功能,降低炎症基因表达,从而抑制乳腺癌细胞的发展[5]。临床试验也进一步证实了限时饮食的益处。多项研究发现限时进食可以显著降低脂肪和体重[24-26]。在一项研究中,要求23名参与者每天10:00—18:00为进食窗口,持续12周后,参与者的体重相比于基线水平下降了4%~6%[27]。此外,O'Donnell等[28]研究对40例乳腺癌病人进行了12周的13 h夜间禁食,结果显示参与者的体质指数中位数相对于基线下降了0.38 kg/m²。另一项研究选择了21例18岁以上确诊为乳腺癌的病人,将其分为每天8 h进食时间的限时饮食组和只有摄入能量减少的限食组,结果显示,限时饮食组中57.1%的病人的体重较初始体重减轻了5%以上,且腰围也缩小得更多[29]。由此可见,通过限时饮食减轻病人的体重,能够降低乳腺癌复发风险,改善病人的预后,提高生存率。这为乳腺癌病人的体重管理提供了一种新的、有效的策略。
慢性炎症反应可激活细胞因子和趋化因子,促进癌细胞增殖、侵袭和转移,还能诱导上皮-间充质转化,增强癌细胞侵袭能力[30]。化疗还导致73%的乳腺癌病人新出现代谢综合征[31],且病人在化疗期间胰岛素抵抗和炎症水平显著增加,化疗后4~5年代谢综合征指标均显著恶化[32]。此外,糖尿病病人因胰岛素抵抗增加,胰岛素和胰岛素样生长因子分泌增加,进而促进乳腺癌发展[33]。研究显示,将参与者随机分配到4 h限时饮食组(15:00—19:00进食)、6 h限时饮食组(13:00—19:00进食)和对照组(无进餐时间限制),持续8周后,两组限时饮食组的氧化应激标志物(8-异前列烷)和胰岛素抵抗均显著降低,能够帮助改善乳腺癌的治疗[34]。有研究选取14名健康受试者,连续4周内每天从黎明到日落禁食超过14 h,只在黎明前吃早餐和日落后吃晚餐,结果发现,多种肿瘤抑制基因蛋白产物水平显著升高,而肿瘤促进基因蛋白产物水平显著下降,参与者的体重、体质指数、腰围和血压显著下降,说明有规律的连续限时饮食能够重置昼夜节律的紊乱,是预防代谢综合征、免疫系统功能障碍和癌症的关键策略[35]。
限时进食作为一种非药物干预措施,在改善乳腺癌病人生活质量方面的作用受到了广泛关注。然而,不同研究的结果存在一定的差异。一方面,限时饮食在改善病人疲劳水平和身体功能方面取得了显著成效。例如,Kleckner等[36]研究中,参与者在经过14 d的自我选择10 h进食的限时饮食干预后,通过功能性慢性疾病治疗疲劳量表(FACIT-F)和简短疲劳量表(BFI)的评估,结果显示其FACIT-F总分上提高了30.6分,BFI评分平均降低了1.0分。这表明限时饮食能够显著改善癌症病人的疲劳水平,从而提升病人的生活质量。另一方面,限时饮食在缓解化疗相关症状方面也表现出了积极的效果。Omar等[13]在48例乳腺癌病人化疗期间进行了限时饮食干预和非限时饮食对照组的对比研究,结果显示,限时饮食组病人的耐受性良好,与化疗毒性相关的症状如恶心、呕吐、腹泻、口腔溃疡和便秘等显著减少。这说明限时饮食能够有效减轻化疗对病人身体的不良影响,进而改善病人的生活质量。然而,也有研究发现限时饮食对病人整体生活质量的提升效果有限。有研究对40例至少6个月前完成辅助或新辅助化疗、放疗和手术后的乳腺癌病人进行了限时饮食干预,结果显示,6周时病人的焦虑水平相对于基线有显著改善,12周时焦虑、抑郁和疲劳水平显著下降,但整体生活质量和体力活动水平未发生变化[28]。说明限时进食在改善乳腺癌病人疲劳水平、缓解化疗相关症状等方面具有一定的积极作用,但对整体生活质量的提升效果尚需进一步研究。尽管如此,限时饮食作为一种关键的非药物干预措施,仍有望在乳腺癌治疗和病人预后改善中发挥重要作用。
限时进食可能对癌症标志物产生积极影响。在小鼠模型中,限时饮食通过减少肿瘤切片中Ki67阳性细胞数量和有丝分裂指数,抑制细胞周期蛋白表达,减缓细胞周期进程,降低细胞增殖和有丝分裂事件,从而抑制乳腺癌细胞增殖。此外,限时饮食还降低了乳腺癌细胞中血管内皮生长因子(VEGF)的表达,减少肿瘤血管生成,进而抑制乳腺癌细胞的生长,降低其复发风险[5]。乳腺癌复发风险还与禁食时间长短相关,Marinac等[14]一项队列研究发现,每晚禁食超过13 h与少于13 h的人群相比,乳腺癌复发的风险降低了36%。因此,限时饮食能够在抑制乳腺癌细胞发展以及降低复发风险上具有较好的作用。
适当的营养和健康的饮食习惯可减轻化疗症状的负担并改善整个癌症连续体的健康状况。有研究证明,限时饮食通过调节代谢和免疫系统,联合化疗药物治疗能够增强疗效,在小鼠模型中,限时饮食与抗癌药物联合治疗通过降低血糖、胰岛素样生长因子1和瘦素水平,增加羟基丁酸水平,减少了肿瘤体积,且未引起肝脏或肾脏毒性[37]。有研究在接种乳腺癌细胞的小鼠上进行持续10 d研究,化疗药物与限时饮食联合治疗对比化疗药物单一治疗,观察得到肿瘤大小明显减小,且治愈率也显著提高[38]。
在一项临床对照试验中,对乳腺癌病人的化疗前、化疗当天及化疗后连续3 d进行限时饮食干预,通过记录病人在每个化疗周期中出现的不良反应,以及在化疗前2 d和第4个化疗周期结束后8 d采集血液样本检测代谢参数、血液学参数和炎症标志物,结果发现,在化疗期间限时饮食能够减少病人化疗相关的毒性反应,包括恶心、呕吐、腹泻和口腔溃疡等,且提高了乳腺癌病人的差异应激抵抗力。这种差异使得正常细胞在面对应激时能够更好地存活,而癌细胞对化疗更敏感,更容易受到损伤或死亡[13,39]。Michalsen等[40]也提到了间歇性禁食能够通过降低胰岛素样生长因子1水平,增加应激抵抗,从而保护正常细胞免受化疗的毒性影响和增加对化疗的耐受性,同时不影响癌细胞的生长抑制。有研究表明,乳腺癌的治疗会导致心脏毒性、代谢功能障碍以及不良的生活方式(缺乏运动、不良饮食以及体重增加),这些会加剧心血管疾病的风险[41]。在一项有22例乳腺癌幸存者的研究中,进行为期8周的8 h进食、16 h禁食的限时饮食方式干预,结果发现病人的内脏脂肪组织减少了5%,心血管疾病风险降低15%,因此,通过限时饮食联合乳腺癌的治疗能够降低病人心血管疾病风险[42]。
限时饮食的一个重要优势是不需要严格限制热量摄入,只需调整进食时间。这种相对宽松的要求使得病人更容易坚持,减少了因严格限制饮食而产生的饥饿感和不适感。Vega等[29]在21例乳腺癌病人中通过限时饮食与热量限制的对照试验中,限时饮食组依从性达到100%,比热量限制组明显高。在一项针对乳腺癌病人的研究中,共22例病人参与了8 h进食、16 h禁食的间歇性禁食计划,结果显示所有病人均积极参与并遵循了该计划,其中98%的病人能够完成至少16 h的禁食[42]。在一项为期12周夜间禁食超过13 h的限时饮食干预试验中,98%的参与者在研究期间至少70%的夜晚记录了13 h的夜间禁食,每周上报≥13 h禁食的天数比例均≥85%,说明乳腺癌病人对限时饮食具有较高的依从性[28]。一项研究在22例60岁及以上的早期乳腺癌病人中进行16∶8的限时饮食干预,在工作日禁食≥16 h的依从性为98%,平均禁食时长为16.7 h,说明有较好的依从性[43]。此外,O'Connor等[44]提出,可根据个体的生物节律、饮食偏好、生活方式和心理需求调整限时饮食的剂量和时间,以提高依从性和健康效果。
Gabel等[45]进行了一项针对23名参与者为期12周的限时饮食干预研究,参与者被要求在每天10:00—18:00进食,其余时间禁食,结果显示,整个干预过程中未观察到任何不良事件;饮食失调症状如暴饮暴食和避免食用禁忌食物以及身体形象感知(如对体型的担忧)均未受到负面影响;参与者的饮食行为,如情绪性饮食和失控性饮食,也未发生显著变化;全血细胞计数参数和β-羟基丁酸水平在干预前后均保持稳定,未见明显波动。因此,限时饮食在乳腺癌病人中具有较好的依从性和安全性。
限时饮食通过调节代谢、改善昼夜节律以及增强细胞自噬等潜在机制,在提升乳腺癌治疗效果、缓解化疗副作用以及显著提高病人生活质量方面发挥了积极作用。然而,其长期效果与安全性仍需通过进一步研究加以验证。未来研究应着重关注个性化饮食计划的制订、多层面因素的相互作用以及长期依从性和健康效果的深入评估,为限时饮食在临床实践中的广泛应用提供坚实的科学依据。

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2026年第40卷第12期
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doi: 10.12102/j.issn.1009-6493.2026.12.024
  • 接收时间:2025-05-22
  • 首发时间:2026-10-30
  • 出版时间:2026-06-25
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  • 收稿日期:2025-05-22
  • 修回日期:2026-05-24
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    1武汉科技大学医学院,湖北 430065

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史崇清,E-mail:
SHI Chongqing, E-mail:
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2种不同金属材料的力学参数
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属
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种数
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species
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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