Article(id=1322931599720980831, tenantId=1146029695717560320, journalId=1220038315760373764, issueId=1322931549481599694, articleNumber=null, orderNo=null, doi=10.12102/j.issn.1009-6493.2026.12.018, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1757001600000, receivedDateStr=2025-09-05, revisedDate=1779638400000, revisedDateStr=2026-05-25, acceptedDate=null, acceptedDateStr=null, onlineDate=1793341072254, onlineDateStr=2026-10-30, pubDate=1782316800000, pubDateStr=2026-06-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793341072254, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793341072254, creator=13701087609, updateTime=1793341072254, updator=13701087609, issue=Issue{id=1322931549481599694, tenantId=1146029695717560320, journalId=1220038315760373764, year='2026', volume='40', issue='12', pageStart='2001', pageEnd='2192', issueExtLink='null', onlineDate='null', pubDate='1782316800000', pubDateStr='2026-06-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793341060276, creator='13701087609', updateTime=1793343118019, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322940180335829530, tenantId=1146029695717560320, journalId=1220038315760373764, issueId=1322931549481599694, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322940180335829531, tenantId=1146029695717560320, journalId=1220038315760373764, issueId=1322931549481599694, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2134, endPage=2137, ext={EN=ArticleExt(id=1322931599922307424, articleId=1322931599720980831, tenantId=1146029695717560320, journalId=1220038315760373764, language=EN, title=Prevention and control effect of carbapenem-resistant Klebsiella pneumoniae infection in intensive care unit, columnId=1220689488284668633, journalTitle=Chinese Nursing Research, columnName=Comprehensive Study, runingTitle=null, highlight=null, articleAbstract=
Objective

To analyze the underlying causes of carbapenem-resistant Klebsiella pneumoniae(CRKP) infection in intensive care unit(ICU) of a certain medical institution,and to systematically evaluate the effectiveness of the implemented control measures,so as to provide a basis for exploring effective strategies to curb the spread of CRKP infections.

Methods

On November 28,2023,4 cases of CRKP infection were detected in the neurology ICU ward of a certain medical institution,with an infection rate of 11.76%.A comprehensive review of the medical records of the patients was conducted,and standardized sampling was carried out on the frequently touched environmental surfaces in the ward.Laboratory tests and analyses of pathogenic microorganisms were also carried out.To identify potential sources of infection and transmission routes,on-site observations and evaluations were conducted on the implementation of hand hygiene by medical staff and the compliance of environmental cleaning and disinfection procedures.

Results

The epidemiological investigation results revealed that the main cause of CRKP infection was closely related to the incomplete disinfection of environmental surfaces in the ward(especially in the frequently touched areas) and the low compliance of medical staff with hand hygiene measures.The hospital administrators promptly formulated and implemented a number of targeted strengthening control measures,and 4 patients recovered and were discharged from the hospital.No CRKP infection cases were found in the hospital.

Conclusions

Strictly implementing thorough disinfection of environmental surfaces and effectively improving the compliance of medical staff with hand hygiene are the key links for quickly controlling the CRKP infection in ICU.Establishing and implementing a strict hospital infection prevention and control system play a decisive role in blocking the transmission of drug-resistant bacteria.

, authors=Jinping LIU, Xiaoling ZHANG, Linping LI, authorsList=Jinping LIU, Xiaoling ZHANG, Linping LI, authorCompany=null, correspAuthors=Jinping LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322931600241074529, articleId=1322931599720980831, tenantId=1146029695717560320, journalId=1220038315760373764, language=CN, title=重症监护病房碳青霉烯类耐药肺炎克雷伯菌感染的防控效果, columnId=1220689488938980091, journalTitle=护理研究, columnName=综合研究, runingTitle=null, highlight=null, articleAbstract=
目的

分析某医疗机构神经内科重症监护病房(ICU)发生的碳青霉烯类耐药肺炎克雷伯菌(CRKP)医院感染的根本原因,系统评估所实施防控措施的效果,为探索有效遏制CRKP感染传播的策略提供依据。

方法

2023年11月28日,某医疗机构神经内科ICU病房集中检出4例CRKP感染病例,感染率达11.76%。全面回顾相关病人病历资料,对病房高频接触环境物体表面进行规范采样,开展病原微生物的实验室检测与分析。为识别潜在感染源与传播途径,对医护人员的手卫生执行情况以及环境清洁消毒操作规范进行了现场观察与评估。

结果

流行病学调查结果揭示,本次CRKP感染的主要原因与病房环境物体表面(尤其是高频接触区域)的消毒不彻底以及医护人员手卫生措施依从性不高密切相关。医院迅速制定并落实了多项针对性强化防控措施,4例病人好转出院,医院未再出现CRKP感染病例。

结论

严格执行环境物体表面的彻底消毒、切实提升医护人员手卫生依从性是迅速控制ICU内CRKP感染的关键环节,构建并落实严格的医院感染防控体系在阻断耐药菌传播中具有重要作用。

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LIU Jinping, E-mail:
刘晋平,本科,E-mail:
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Basic information of patients infected with CRKP

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病例号年龄(岁)性别入院诊断标本类型检查前入住
ICU天数(d)
中心静脉置管机械通气
天数(d)
使用纤维
支气管镜
检查前使用
碳青霉烯类药物
例164女脑梗死痰13否0否否
例278男癫痫痰5否13否是
例368男脑出血痰7否0是否
例471女癫痫痰12否32否否
), ArticleFig(id=1322931603898507645, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931599720980831, language=CN, label=表1, caption=

CRKP感染病人基本情况

, figureFileSmall=null, figureFileBig=null, tableContent=
病例号年龄(岁)性别入院诊断标本类型检查前入住
ICU天数(d)
中心静脉置管机械通气
天数(d)
使用纤维
支气管镜
检查前使用
碳青霉烯类药物
例164女脑梗死痰13否0否否
例278男癫痫痰5否13否是
例368男脑出血痰7否0是否
例471女癫痫痰12否32否否
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重症监护病房碳青霉烯类耐药肺炎克雷伯菌感染的防控效果
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刘晋平 , 张小玲 , 李临平
护理研究 | 综合研究 2026,40(12): 2134-2137
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护理研究 |综合研究 2026 , 40 (12) : 2134 -2137
重症监护病房碳青霉烯类耐药肺炎克雷伯菌感染的防控效果
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刘晋平 , 张小玲, 李临平
作者信息
  • 1山西省人民医院,山西 030012
通讯作者:
LIU Jinping, E-mail:
刘晋平,本科,E-mail:
Prevention and control effect of carbapenem-resistant Klebsiella pneumoniae infection in intensive care unit
Jinping LIU , Xiaoling ZHANG, Linping LI
Affiliations
  • 1Shanxi Provincial People's Hospital, Shanxi 030012 China
出版时间: 2026-06-25 doi: 10.12102/j.issn.1009-6493.2026.12.018
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目的

分析某医疗机构神经内科重症监护病房(ICU)发生的碳青霉烯类耐药肺炎克雷伯菌(CRKP)医院感染的根本原因,系统评估所实施防控措施的效果,为探索有效遏制CRKP感染传播的策略提供依据。

方法

2023年11月28日,某医疗机构神经内科ICU病房集中检出4例CRKP感染病例,感染率达11.76%。全面回顾相关病人病历资料,对病房高频接触环境物体表面进行规范采样,开展病原微生物的实验室检测与分析。为识别潜在感染源与传播途径,对医护人员的手卫生执行情况以及环境清洁消毒操作规范进行了现场观察与评估。

结果

流行病学调查结果揭示,本次CRKP感染的主要原因与病房环境物体表面(尤其是高频接触区域)的消毒不彻底以及医护人员手卫生措施依从性不高密切相关。医院迅速制定并落实了多项针对性强化防控措施,4例病人好转出院,医院未再出现CRKP感染病例。

结论

严格执行环境物体表面的彻底消毒、切实提升医护人员手卫生依从性是迅速控制ICU内CRKP感染的关键环节,构建并落实严格的医院感染防控体系在阻断耐药菌传播中具有重要作用。

重症监护病房  /  耐药菌感染  /  碳青霉烯类耐药肺炎克雷伯菌  /  医院感染
Objective

To analyze the underlying causes of carbapenem-resistant Klebsiella pneumoniae(CRKP) infection in intensive care unit(ICU) of a certain medical institution,and to systematically evaluate the effectiveness of the implemented control measures,so as to provide a basis for exploring effective strategies to curb the spread of CRKP infections.

Methods

On November 28,2023,4 cases of CRKP infection were detected in the neurology ICU ward of a certain medical institution,with an infection rate of 11.76%.A comprehensive review of the medical records of the patients was conducted,and standardized sampling was carried out on the frequently touched environmental surfaces in the ward.Laboratory tests and analyses of pathogenic microorganisms were also carried out.To identify potential sources of infection and transmission routes,on-site observations and evaluations were conducted on the implementation of hand hygiene by medical staff and the compliance of environmental cleaning and disinfection procedures.

Results

The epidemiological investigation results revealed that the main cause of CRKP infection was closely related to the incomplete disinfection of environmental surfaces in the ward(especially in the frequently touched areas) and the low compliance of medical staff with hand hygiene measures.The hospital administrators promptly formulated and implemented a number of targeted strengthening control measures,and 4 patients recovered and were discharged from the hospital.No CRKP infection cases were found in the hospital.

Conclusions

Strictly implementing thorough disinfection of environmental surfaces and effectively improving the compliance of medical staff with hand hygiene are the key links for quickly controlling the CRKP infection in ICU.Establishing and implementing a strict hospital infection prevention and control system play a decisive role in blocking the transmission of drug-resistant bacteria.

intensive care unit,ICU  /  drug-resistant bacterial infection  /  carbapenem-resistant Klebsiella pneumoniae  /  hospital infection
刘晋平, 张小玲, 李临平. 重症监护病房碳青霉烯类耐药肺炎克雷伯菌感染的防控效果. 护理研究, 2026 , 40 (12) : 2134 -2137 . DOI: 10.12102/j.issn.1009-6493.2026.12.018
Jinping LIU, Xiaoling ZHANG, Linping LI. Prevention and control effect of carbapenem-resistant Klebsiella pneumoniae infection in intensive care unit[J]. Chinese Nursing Research, 2026 , 40 (12) : 2134 -2137 . DOI: 10.12102/j.issn.1009-6493.2026.12.018
近年来,耐药菌感染在全球范围内逐渐成为公共卫生的重大威胁,尤其是在重症监护病房(ICU)等高风险医疗环境中,耐药菌的传播对病人安全构成了巨大风险[1-2]。其中,碳青霉烯类耐药肺炎克雷伯菌(carbapenem-resistant Klebsiella pneumoniae,CRKP)因具有广泛耐药性,易在ICU等环境中形成医院感染暴发,为临床治疗和感染控制带来了严峻挑战[3-5]。ICU病人通常伴有多种基础疾病、免疫力低下,并频繁接受侵入性治疗,这些因素增加了耐药菌感染的风险[6-7]。因此,有效识别并控制CRKP等耐药菌的传播是当前医疗机构的重要任务[8]。CRKP感染在ICU环境中的蔓延不仅影响病人的治疗效果,还给医院的感染控制、医疗资源管理和卫生经济负担带来巨大压力[9]。CRKP的高感染率和高耐药性使得一旦暴发,可能会形成难以控制的感染链条,导致病人病死率的增加。如何加强ICU环境中CRKP等耐药菌的监测和防控,已成为降低医院感染率、保障病人安全、优化医疗资源配置的关键环节。本研究旨在通过总结某医疗机构ICU内CRKP感染暴发事件的调查和防控过程,分析此次事件的感染源头、传播途径、风险因素以及采取的具体防控措施。通过对环境和物表的规范化采样、病原学检测以及手卫生管理等干预手段的评估,明确这些措施在遏制CRKP感染扩散中的作用和效果。在国家卫生健康委员会发布《全面提升医疗质量行动计划(2023—2025年)》[10]和《手术质量安全提升行动方案(2023—2025年)》[11]的背景下,通过对此次ICU内CRKP感染暴发事件进行分析,总结防控措施,有助于积累应对耐药菌感染暴发的经验,为其他医疗机构在高风险环境中开展耐药菌防控工作提供科学依据,进而提高ICU耐药菌感染的防控水平。
2023年11月28日,某医疗机构神经内科ICU病房集中检出4例CRKP感染病例,感染率达11.76%,显著高于该科室历史基线水平。所有病人均在同一病房区域接受治疗。依据《中国碳青霉烯耐药肠杆菌科细菌感染诊治与防控专家共识(2022年版)》,本研究将CRKP医院感染病例定义为:在神经内科ICU住院期间(≥48 h后),经合格痰标本培养分离出CRKP的病人。医院感染暴发判定参照我国《医院感染暴发控制指南(WS/T 524—2016)》,当同一病区在短时间内出现≥3例同种同源病原体感染病例,且存在流行病学关联时,可判定为疑似感染暴发。本研究中4例CRKP感染病例集中发生于9 d内,病原体相同,且具有时空聚集性,符合疑似感染暴发判定标准。本研究已获得山西省人民医院伦理委员会批准(批件编号:〔2025〕省医科伦审字第755号)。
通过现场调查,绘制感染病例时间轴,分布于暴发感染平面图,对指示病例同一病房的其他病人及相关联的医务人员开展流行病学调查,包括暴发病人的时空分布、抗菌药物敏感性分析、环境筛查和病原学检测。
对暴发期间居住于同一病房的所有住院病人开展痰培养检测,依据美国临床和实验室标准协会(Clinical and Laboratory Standards Institute,CLSI)关于碳青霉烯类抗生素的折点,结合常规药敏试验结果判定并报告CRKP。同时,按照《医院消毒卫生标准(GB 15982—2012)》要求,采集环境样品进行病原菌分离培养,采样部位包括医护人员手部、工作服、听诊器、治疗车、床挡,以及呼吸机面板、洗手池等高频接触物体表面。
结合现场流行病学调查与实验室检测结果,分析本次疑似医院感染暴发的可能原因如下:1)人员因素,医务人员在为多重耐药菌病人进行诊疗操作时未规范穿脱隔离衣,导致工作服污染;未严格执行隔离诊疗措施,未对感染病人固定医护及护理人员;医生、护理人员及保洁人员手卫生依从性不足;ICU环境清洁消毒由护理员承担,随时消毒落实不到位。2)设备及环境因素,听诊器、瞳孔笔等诊疗用品未做到专人专用;排痰仪、心电图机、输液泵等重复使用设备消毒不规范;吸痰等产生气溶胶操作后的床单元擦拭由护理员完成,消毒效果难以保障。3)消毒及隔离用品配备与使用,隔离衣数量不足无法满足每日更换与清洗消毒需求;消毒剂配制方法不规范,浓度不达标;床单元消毒措施虽已执行,但效果无法保证。
针对上述问题,研究团队以多准则决策分析法(MCDA)为理论框架,通过系统文献回顾、感染控制专家咨询(含2名省级感染防控专家)及ICU护理骨干参与的多轮讨论,构建了一套以护理操作为核心、实用性强的综合防控方案。1)向科室下达感染管理监督意见书,要求即刻整改并追踪措施落实情况。暂停收治新病人,对监护室环境及所有物体表面进行全面清洁与消毒。使用含氯消毒剂(有效氯500 mg/L)对高频接触物体表面每日消毒2次(暴发期增至4次)。2)通过问卷星平台组织科室全员开展CRKP防控知识培训与考核。3)加强医务人员手卫生依从性督导,配备足量隔离衣,确保正确穿脱及每日更换,强化科室医院感染防控措施执行的质量控制,由专职人员持续追踪整改成效。4)在病房门口安装声控手卫生提醒装置,提示进出人员落实手卫生。5)对CRKP感染病人实施单间隔离,若条件受限则安置于单独隔断区域,实行床位集中管理,固定护理人员,公用仪器设备使用后严格消毒。为每例CRKP病人配备不少于2件隔离衣及面屏;床旁固定专用治疗盘、体温计、听诊器、利器盒、剪刀、垃圾桶、手套及消毒液;同时加强对护工手卫生及隔离衣规范使用的宣教与督导,并强化医生、护士手卫生执行的日常监督。
通过查看病例并逐一梳理感染经过,判断病例之间是否存在关联性,感染源为11月4日的首例CRKP社区感染病例。4例医院感染病人中,男2例,女2例;年龄64~78岁;癫痫2例,脑梗死1例,脑出血1例;2例接受机械通气,1例检出前使用碳青霉烯类药物;原发病较重,普遍存在意识障碍、肢体活动受限等问题。在严格执行感染控制措施的情况下对同病房其他病人及医务人员进行临床症状、相关实验室检查。通过严格执行防控措施,截至2023年12月20日,该ICU未再出现新的感染病例,环境监测结果均未检测出目标菌,此次疑似医院感染暴发得到有效控制。4例感染病人接受了适当的抗菌药物治疗,最终好转出院。详见表1。
ICU作为危重症病人集中救治的高风险区域,CRKP的检出率持续上升,其广泛耐药性及在环境中长期存活的能力,极易引发难以控制的医院感染暴发,显著增加病人病死率与医疗负担[12-15]。本研究分析了某医疗机构神经内科ICU检出4例CRKP下呼吸道感染病例的聚集性事件。尽管受限于样本量小、未设置对照组及未开展菌株分子同源性分析,无法确立因果关系或排除季节性波动、抗生素使用变化等混杂因素影响,但综合流行病学调查、环境采样及行为观察结果提示,手卫生依从性不足与环境物体表面(如呼吸机面板、洗手池、排痰仪)清洁消毒不彻底可能是本次事件的重要风险因素[16-18]。值得注意的是,环境采样虽在护士手部、洗手池等5处检出CRKP,但因未进行脉冲场凝胶泳或全基因组测序同源分析,仅能提示环境污染与病人感染可能存在关联,无法确认为直接感染源[19]。干预实施后,2023年12月起该ICU未再报告新发CRKP病例。然而,由于本研究为回顾性描述性设计,缺乏前瞻性对照及量化的效果评估指标(如手卫生依从率提升幅度等),不能将“零新增”归因于干预措施本身。但所构建的防控举措,尤其是将接触隔离、环境强化消毒与护理执行紧密结合,在本机构条件下展现出良好的可操作性与接受度,为资源有限的ICU提供了可复制的实践路径[20-21]。
本案例的核心启示:1)CRKP防控需聚焦高频接触环境与手卫生两大关键环节,并明确消毒剂种类、浓度与频次等操作细节;2)护理团队在措施执行中扮演核心角色,固定护理人员、专人专用物品、强化护工培训是保障措施落地的关键;3)应将CRKP纳入ICU目标性监测清单,推动“首例即响应”的标准化预警流程,避免因响应延迟导致病例扩散。
本研究存在明显局限性:病例数少、无对照、未纳入机械通气时长、侵入性操作次数、抗生素暴露史等关键临床风险因素,且未量化干预前后行为指标变化。因此,所提方案的有效性需通过设置对照的类试验或前瞻性研究进一步验证。未来工作应聚焦于建立包含基线风险分层、过程指标监测(如手卫生依从率、环境清洁合格率)和结局指标(如CRKP感染率)的综合评价体系,以科学评估防控策略的效果。

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doi: 10.12102/j.issn.1009-6493.2026.12.018
  • 接收时间:2025-09-05
  • 首发时间:2026-10-30
  • 出版时间:2026-06-25
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  • 收稿日期:2025-09-05
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    1山西省人民医院,山西 030012

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2种不同金属材料的力学参数
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genus
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species
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Percentage of
total species (%)
属
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species
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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