Article(id=1322931592204780528, tenantId=1146029695717560320, journalId=1220038315760373764, issueId=1322931549481599694, articleNumber=null, orderNo=null, doi=10.12102/j.issn.1009-6493.2026.12.026, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1746979200000, receivedDateStr=2025-05-12, revisedDate=1780416000000, revisedDateStr=2026-06-03, acceptedDate=null, acceptedDateStr=null, onlineDate=1793341070462, onlineDateStr=2026-10-30, pubDate=1782316800000, pubDateStr=2026-06-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793341070462, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793341070462, creator=13701087609, updateTime=1793341070462, updator=13701087609, issue=Issue{id=1322931549481599694, tenantId=1146029695717560320, journalId=1220038315760373764, year='2026', volume='40', issue='12', pageStart='2001', pageEnd='2192', issueExtLink='null', onlineDate='null', pubDate='1782316800000', pubDateStr='2026-06-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793341060276, creator='13701087609', updateTime=1793343118019, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322940180335829530, tenantId=1146029695717560320, journalId=1220038315760373764, issueId=1322931549481599694, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322940180335829531, tenantId=1146029695717560320, journalId=1220038315760373764, issueId=1322931549481599694, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2185, endPage=2188, ext={EN=ArticleExt(id=1322931592615822321, articleId=1322931592204780528, tenantId=1146029695717560320, journalId=1220038315760373764, language=EN, title=Progress on application of vocal biomarkers in the management of patients with chronic diseases, columnId=1220689485315101342, journalTitle=Chinese Nursing Research, columnName=Review Articles, runingTitle=null, highlight=null, articleAbstract=

This study expounded the concept and types of vocal biomarkers.It reviewed the application,challenges and prospects of vocal biomarkers in chronic disease management,so as to provide a reference for accelerating the development of precise and personalized chronic disease management.

, authors=Xiaofei HE, Yuxiao JIAO, Lulu MA, Bo ZHANG, Lanyu ZHU, authorsList=Xiaofei HE, Yuxiao JIAO, Lulu MA, Bo ZHANG, Lanyu ZHU, authorCompany=null, correspAuthors=Lanyu ZHU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322931594742334450, articleId=1322931592204780528, tenantId=1146029695717560320, journalId=1220038315760373764, language=CN, title=语音生物标记物在慢性病病人管理中的应用进展, columnId=1220689485482873504, journalTitle=护理研究, columnName=科研综述, runingTitle=null, highlight=null, articleAbstract=

阐述了语音生物标记物的概念、类型,综述了语音生物标记物在慢性病管理中的应用、挑战及展望,以期为加快精准化、个性化的慢性病管理提供参考。

, authors=何晓菲, 矫玉晓, 马璐璐, 张博, 朱蓝玉*, *, authorsList=何晓菲, 矫玉晓, 马璐璐, 张博, 朱蓝玉, authorCompany=null, correspAuthors=朱蓝玉, authorNote=

何晓菲,护士,硕士研究生在读

, correspAuthorsNote=
朱蓝玉,E-mail:
ZHU Lanyu, E-mail:
, copyrightStatement=除非特别声明,本刊刊出的所有文章不代表本刊编委会的观点。, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=XGQhCfY7NS90DuOI/TdEJw==, magXml=HmhdbAahAykucD91Xei8Eg==, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=KH6yPsQqbVmp+5DAuiS5tA==, mapNumber=null, fund=null)}, authors=[Author(id=1322931595920933879, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322931596059345913, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931595920933879, language=EN, stringName=Xiaofei HE, firstName=Xiaofei, middleName=null, lastName=HE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1Changchun University of Chinese Medicine, Jilin 130117 China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322931596315198458, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931595920933879, language=CN, stringName=何晓菲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1长春中医药大学,吉林 130117, bio={"content":"

何晓菲,护士,硕士研究生在读

"}, bioImg=null, bioContent=

何晓菲,护士,硕士研究生在读

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322931595543446515, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, xref=1, ext=[AuthorCompanyExt(id=1322931595572806644, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Changchun University of Chinese Medicine, Jilin 130117 China), AuthorCompanyExt(id=1322931595581195253, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1长春中医药大学,吉林 130117)])]), Author(id=1322931596394890236, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322931596487164926, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931596394890236, language=EN, stringName=Yuxiao JIAO, firstName=Yuxiao, middleName=null, lastName=JIAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1Changchun University of Chinese Medicine, Jilin 130117 China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322931596571051007, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931596394890236, language=CN, stringName=矫玉晓, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1长春中医药大学,吉林 130117, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322931595543446515, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, xref=1, ext=[AuthorCompanyExt(id=1322931595572806644, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Changchun University of Chinese Medicine, Jilin 130117 China), AuthorCompanyExt(id=1322931595581195253, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1长春中医药大学,吉林 130117)])]), Author(id=1322931596663324672, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322931596814319618, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931596663324672, language=EN, stringName=Lulu MA, firstName=Lulu, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1Changchun University of Chinese Medicine, Jilin 130117 China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322931596902400003, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931596663324672, language=CN, stringName=马璐璐, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1长春中医药大学,吉林 130117, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322931595543446515, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, xref=1, ext=[AuthorCompanyExt(id=1322931595572806644, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Changchun University of Chinese Medicine, Jilin 130117 China), AuthorCompanyExt(id=1322931595581195253, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1长春中医药大学,吉林 130117)])]), Author(id=1322931598592704518, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322931598697562120, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931598592704518, language=EN, stringName=Bo ZHANG, firstName=Bo, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1Changchun University of Chinese Medicine, Jilin 130117 China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322931598773059593, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931598592704518, language=CN, stringName=张博, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1长春中医药大学,吉林 130117, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322931595543446515, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, xref=1, ext=[AuthorCompanyExt(id=1322931595572806644, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Changchun University of Chinese Medicine, Jilin 130117 China), AuthorCompanyExt(id=1322931595581195253, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1长春中医药大学,吉林 130117)])]), Author(id=1322931598869528587, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=13588836@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322931598961803277, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931598869528587, language=EN, stringName=Lanyu ZHU, firstName=Lanyu, middleName=null, lastName=ZHU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1Changchun University of Chinese Medicine, Jilin 130117 China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322931599033106446, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931598869528587, language=CN, stringName=朱蓝玉, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=*, *, address=1长春中医药大学,吉林 130117, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322931595543446515, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, xref=1, ext=[AuthorCompanyExt(id=1322931595572806644, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Changchun University of Chinese Medicine, Jilin 130117 China), AuthorCompanyExt(id=1322931595581195253, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1长春中医药大学,吉林 130117)])])], keywords=[Keyword(id=1322931599129575440, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, language=EN, orderNo=1, keyword=chronic diseases), Keyword(id=1322931599288958993, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, language=EN, orderNo=2, keyword=vocal biomarkers), Keyword(id=1322931599356067858, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, language=EN, orderNo=3, keyword=health management), Keyword(id=1322931599439953939, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, language=EN, orderNo=4, keyword=artificial intelligence), Keyword(id=1322931599519645716, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, language=EN, orderNo=5, keyword=review), Keyword(id=1322931599590948885, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, language=CN, orderNo=1, keyword=慢性病), Keyword(id=1322931599666446358, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, language=CN, orderNo=2, keyword=语音生物标记物), Keyword(id=1322931599750332439, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, language=CN, orderNo=3, keyword=健康管理), Keyword(id=1322931599838412824, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, language=CN, orderNo=4, keyword=人工智能), Keyword(id=1322931599930687513, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, language=CN, orderNo=5, keyword=综述)], refs=[Reference(id=1322931600048128026, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=24, issue=1, pageStart=559, pageEnd=null, url=null, language=null, rfNumber=1, rfOrder=0, authorNames=Chen J D, Zhang F, Zhang Y, journalName=BMC Public Health, refType=null, unstructuredReference=Chen J D,Zhang F,Zhang Y,et al.Trajectories network analysis of chronic diseases among middle-aged and older adults:evidence from the China health and retirement longitudinal study(CHARLS)[J].BMC Public Health,2024,24(1):559., articleTitle=Trajectories network analysis of chronic diseases among middle-aged and older adults:evidence from the China health and retirement longitudinal study(CHARLS), refAbstract=null), Reference(id=1322931600119431195, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2025, volume=13, issue=null, pageStart=1506545, pageEnd=null, url=null, language=null, rfNumber=2, rfOrder=1, authorNames=Shao Y J, Duan X C, Xu X J, journalName=Frontiers in Public Health, refType=null, unstructuredReference=Shao Y J,Duan X C,Xu X J,et al.Latent profile and determinants of self-management behaviors among older adult patients with chronic diseases:a cross-sectional study[J].Frontiers in Public Health,2025,13:1506545., articleTitle=Latent profile and determinants of self-management behaviors among older adult patients with chronic diseases:a cross-sectional study, refAbstract=null), Reference(id=1322931600199122972, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=41, issue=11, pageStart=5, pageEnd=8, url=null, language=null, rfNumber=3, rfOrder=2, authorNames=王文霞, 韩舒羽, 单锶楷, journalName=军事护理, refType=null, unstructuredReference=王文霞,韩舒羽,单锶楷,等.美国国立卫生研究院对语音生物标记物相关科研资助项目分析[J].军事护理,2024,41(11):5-8., articleTitle=美国国立卫生研究院对语音生物标记物相关科研资助项目分析, refAbstract=null), Reference(id=1322931600262037533, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2023, volume=98, issue=9, pageStart=1353, pageEnd=1375, url=null, language=null, rfNumber=4, rfOrder=3, authorNames=Sara J D S, Orbelo D, Maor E, journalName=Mayo Clinic Proceedings, refType=null, unstructuredReference=Sara J D S,Orbelo D,Maor E,et al.Guess what we can hear-novel voice biomarkers for the remote detection of disease[J].Mayo Clinic Proceedings,2023,98(9):1353-1375., articleTitle=Guess what we can hear-novel voice biomarkers for the remote detection of disease, refAbstract=null), Reference(id=1322931600345923614, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2023, volume=6, issue=null, pageStart=228, pageEnd=null, url=null, language=null, rfNumber=5, rfOrder=4, authorNames=Bowden M, Beswick E, Tam J, journalName=Digital Medicine, refType=null, unstructuredReference=Bowden M,Beswick E,Tam J,et al.A systematic review and narrative analysis of digital speech biomarkers in motor neurone disease[J].Digital Medicine,2023,6:228., articleTitle=A systematic review and narrative analysis of digital speech biomarkers in motor neurone disease, refAbstract=null), Reference(id=1322931600442392607, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=6, issue=8, pageStart=303, pageEnd=312, url=null, language=null, rfNumber=6, rfOrder=5, authorNames=Okada K, Mizuguchi D, Omiya Y, journalName=Circulation Reports, refType=null, unstructuredReference=Okada K,Mizuguchi D,Omiya Y,et al.Clinical utility of machine learning-derived vocal biomarkers in the management of heart failure[J].Circulation Reports,2024,6(8):303-312., articleTitle=Clinical utility of machine learning-derived vocal biomarkers in the management of heart failure, refAbstract=null), Reference(id=1322931600509501472, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=24, issue=4, pageStart=1173, pageEnd=null, url=null, language=null, rfNumber=7, rfOrder=6, authorNames=Kapetanidis P, Kalioras F, Tsakonas C, journalName=Sensors, refType=null, unstructuredReference=Kapetanidis P,Kalioras F,Tsakonas C,et al.Respiratory diseases diagnosis using audio analysis and artificial intelligence:a systematic review[J].Sensors,2024,24(4):1173., articleTitle=Respiratory diseases diagnosis using audio analysis and artificial intelligence:a systematic review, refAbstract=null), Reference(id=1322931600593387553, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=9, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=8, rfOrder=7, authorNames=Oreskovic J, Kaufman J, Fossat Y, journalName=JMIR Biomedical Engineering, refType=null, unstructuredReference=Oreskovic J,Kaufman J,Fossat Y.Impact of audio data compression on feature extraction for vocal biomarker detection:validation study[J].JMIR Biomedical Engineering,2024,9:e56246., articleTitle=Impact of audio data compression on feature extraction for vocal biomarker detection:validation study, refAbstract=null), Reference(id=1322931600660496418, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=6, issue=null, pageStart=1440986, pageEnd=null, url=null, language=null, rfNumber=9, rfOrder=8, authorNames=Tröger J, Dörr F, Schwed L, journalName=Frontiers in Digital Health, refType=null, unstructuredReference=Tröger J,Dörr F,Schwed L,et al.An automatic measure for speech intelligibility in dysarthrias-validation across multiple languages and neurological disorders[J].Frontiers in Digital Health,2024,6:1440986., articleTitle=An automatic measure for speech intelligibility in dysarthrias-validation across multiple languages and neurological disorders, refAbstract=null), Reference(id=1322931600735993891, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2023, volume=17, issue=null, pageStart=1302132, pageEnd=null, url=null, language=null, rfNumber=10, rfOrder=9, authorNames=Saab R, Balachandar A, Mahdi H, journalName=Frontiers in Neuroscience, refType=null, unstructuredReference=Saab R,Balachandar A,Mahdi H,et al.Machine-learning assisted swallowing assessment:a deep learning-based quality improvement tool to screen for post-stroke dysphagia[J].Frontiers in Neuroscience,2023,17:1302132., articleTitle=Machine-learning assisted swallowing assessment:a deep learning-based quality improvement tool to screen for post-stroke dysphagia, refAbstract=null), Reference(id=1322931600819879972, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2022, volume=119, issue=null, pageStart=22, pageEnd=35, url=null, language=null, rfNumber=11, rfOrder=10, authorNames=Mahon E, Lachman M E, journalName=Neurobiology of Aging, refType=null, unstructuredReference=Mahon E,Lachman M E.Voice biomarkers as indicators of cognitive changes in middle and later adulthood[J].Neurobiology of Aging,2022,119:22-35., articleTitle=Voice biomarkers as indicators of cognitive changes in middle and later adulthood, refAbstract=null), Reference(id=1322931600916348965, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=10.1007/s10803-025-06757-4, pmid=null, pmcid=null, year=2025, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=12, rfOrder=11, authorNames=Pusil S, Laguna A, Chino B, journalName=Journal of Autism and Developmental Disorders, refType=null, unstructuredReference=Pusil S,Laguna A,Chino B,et al.Early identification of autism using cry analysis:a systematic review and meta-analysis of retrospective and prospective studies[J].Journal of Autism and Developmental Disorders,2025., articleTitle=Early identification of autism using cry analysis:a systematic review and meta-analysis of retrospective and prospective studies, refAbstract=null), Reference(id=1322931600987652134, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=20, issue=8, pageStart=5262, pageEnd=5270, url=null, language=null, rfNumber=13, rfOrder=12, authorNames=Amini S, Hao B R, Yang J M, journalName=Alzheimer's & Dementia, refType=null, unstructuredReference=Amini S,Hao B R,Yang J M,et al.Prediction of Alzheimer's disease progression within 6 years using speech:a novel approach leveraging language models[J].Alzheimer's & Dementia,2024,20(8):5262-5270., articleTitle=Prediction of Alzheimer's disease progression within 6 years using speech:a novel approach leveraging language models, refAbstract=null), Reference(id=1322931601071538215, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=16, issue=1, pageStart=26, pageEnd=null, url=null, language=null, rfNumber=14, rfOrder=13, authorNames=García-Gutiérrez F, Alegret M, Marquié M, journalName=Alzheimer's Research & Therapy, refType=null, unstructuredReference=García-Gutiérrez F,Alegret M,Marquié M,et al.Unveiling the sound of the cognitive status:machine learning-based speech analysis in the Alzheimer's disease spectrum[J].Alzheimer's Research & Therapy,2024,16(1):26., articleTitle=Unveiling the sound of the cognitive status:machine learning-based speech analysis in the Alzheimer's disease spectrum, refAbstract=null), Reference(id=1322931601138647080, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2025, volume=13, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=15, rfOrder=14, authorNames=Kim T, Choi J Y, Ko M J, journalName=JMIR Medical Informatics, refType=null, unstructuredReference=Kim T,Choi J Y,Ko M J,et al.Development and validation of a machine learning method using vocal biomarkers for identifying frailty in community-dwelling older adults:cross-sectional study[J].JMIR Medical Informatics,2025,13:e57298., articleTitle=Development and validation of a machine learning method using vocal biomarkers for identifying frailty in community-dwelling older adults:cross-sectional study, refAbstract=null), Reference(id=1322931601230921769, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=59, issue=16, pageStart=2044, pageEnd=2048, url=null, language=null, rfNumber=16, rfOrder=15, authorNames=杨建梅, 林桂如, 欧婉仪, journalName=中华护理杂志, refType=null, unstructuredReference=杨建梅,林桂如,欧婉仪,等.多组学技术在临床护理研究中的应用进展[J].中华护理杂志,2024,59(16):2044-2048., articleTitle=多组学技术在临床护理研究中的应用进展, refAbstract=null), Reference(id=1322931601289642026, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2022, volume=11, issue=21, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=17, rfOrder=16, authorNames=Schöbi D, Zhang Y P, Kehl J, journalName=Journal of the American Heart Association, refType=null, unstructuredReference=Schöbi D,Zhang Y P,Kehl J,et al.Evaluation of speech and pause alterations in patients with acute and chronic heart failure[J].Journal of the American Heart Association,2022,11(21):e027023., articleTitle=Evaluation of speech and pause alterations in patients with acute and chronic heart failure, refAbstract=null), Reference(id=1322931601348362283, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2022, volume=1, issue=10, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=18, rfOrder=17, authorNames=Fagherazzi G, Zhang L, Elbéji A, journalName=PLoS Digital Health, refType=null, unstructuredReference=Fagherazzi G,Zhang L,Elbéji A,et al.A voice-based biomarker for monitoring symptom resolution in adults with COVID-19:findings from the prospective predi-COVID cohort study[J].PLoS Digital Health,2022,1(10):e0000112., articleTitle=A voice-based biomarker for monitoring symptom resolution in adults with COVID-19:findings from the prospective predi-COVID cohort study, refAbstract=null), Reference(id=1322931603047055404, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=10.1016/j.jvoice.2025.01.002, pmid=null, pmcid=null, year=2025, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=19, rfOrder=18, authorNames=Briganti G, Lechien J R, journalName=Journal of Voice, refType=null, unstructuredReference=Briganti G,Lechien J R.Voice quality as digital biomarker in bipolar disorder:a systematic review[J].Journal of Voice,2025., articleTitle=Voice quality as digital biomarker in bipolar disorder:a systematic review, refAbstract=null), Reference(id=1322931603139330093, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2025, volume=30, issue=6, pageStart=2686, pageEnd=2695, url=null, language=null, rfNumber=20, rfOrder=19, authorNames=Di Y Z, Rahmani E, Mefford J, journalName=Molecular Psychiatry, refType=null, unstructuredReference=Di Y Z,Rahmani E,Mefford J,et al.Unraveling the associations between voice pitch and major depressive disorder:a multisite genetic study[J].Molecular Psychiatry,2025,30(6):2686-2695., articleTitle=Unraveling the associations between voice pitch and major depressive disorder:a multisite genetic study, refAbstract=null), Reference(id=1322931603219021870, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2025, volume=23, issue=1, pageStart=60, pageEnd=65, url=null, language=null, rfNumber=21, rfOrder=20, authorNames=Mazur A, Costantino H, Tom P, journalName=Annals of Family Medicine, refType=null, unstructuredReference=Mazur A,Costantino H,Tom P,et al.Evaluation of an AI-based voice biomarker tool to detect signals consistent with moderate to severe depression[J].Annals of Family Medicine,2025,23(1):60-65., articleTitle=Evaluation of an AI-based voice biomarker tool to detect signals consistent with moderate to severe depression, refAbstract=null), Reference(id=1322931603437125679, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2017, volume=20, issue=4, pageStart=919, pageEnd=935, url=null, language=null, rfNumber=22, rfOrder=21, authorNames=Kiss G, Vicsi K, journalName=International Journal of Speech Technology, refType=null, unstructuredReference=Kiss G,Vicsi K.Mono- and multi-lingual depression prediction based on speech processing[J].International Journal of Speech Technology,2017,20(4):919-935., articleTitle=Mono- and multi-lingual depression prediction based on speech processing, refAbstract=null), Reference(id=1322931603583926320, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2020, volume=216, issue=null, pageStart=24, pageEnd=40, url=null, language=null, rfNumber=23, rfOrder=22, authorNames=Parola A, Simonsen A, Bliksted V, journalName=Schizophrenia Research, refType=null, unstructuredReference=Parola A,Simonsen A,Bliksted V,et al.Voice patterns in schizophrenia:a systematic review and Bayesian meta-analysis[J].Schizophrenia Research,2020,216:24-40., articleTitle=Voice patterns in schizophrenia:a systematic review and Bayesian meta-analysis, refAbstract=null), Reference(id=1322931603869138993, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2020, volume=5, issue=1, pageStart=96, pageEnd=116, url=null, language=null, rfNumber=24, rfOrder=23, authorNames=Low D M, Bentley K H, Ghosh S S, journalName=Laryngoscope Investigative Otolaryngology, refType=null, unstructuredReference=Low D M,Bentley K H,Ghosh S S.Automated assessment of psychiatric disorders using speech:a systematic review[J].Laryngoscope Investigative Otolaryngology,2020,5(1):96-116., articleTitle=Automated assessment of psychiatric disorders using speech:a systematic review, refAbstract=null), Reference(id=1322931603932053554, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=15, issue=null, pageStart=1342835, pageEnd=null, url=null, language=null, rfNumber=25, rfOrder=24, authorNames=Larsen E, Murton O, Song X Y, journalName=Frontiers in Psychiatry, refType=null, unstructuredReference=Larsen E,Murton O,Song X Y,et al.Validating the efficacy and value proposition of mental fitness vocal biomarkers in a psychiatric population:prospective cohort study[J].Frontiers in Psychiatry,2024,15:1342835., articleTitle=Validating the efficacy and value proposition of mental fitness vocal biomarkers in a psychiatric population:prospective cohort study, refAbstract=null), Reference(id=1322931604275986483, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=26, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=26, rfOrder=25, authorNames=Riad R, Denais M, de Gennes M, journalName=Journal of Medical Internet Research, refType=null, unstructuredReference=Riad R,Denais M,de Gennes M,et al.Automated speech analysis for risk detection of depression,anxiety,insomnia,and fatigue:algorithm development and validation study[J].Journal of Medical Internet Research,2024,26:e58572., articleTitle=Automated speech analysis for risk detection of depression,anxiety,insomnia,and fatigue:algorithm development and validation study, refAbstract=null), Reference(id=1322931604380844084, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2022, volume=61, issue=5, pageStart=520, pageEnd=526, url=null, language=null, rfNumber=27, rfOrder=26, authorNames=陈耕耘, 李圣辰, 邵曦, journalName=复旦学报(自然科学版), refType=null, unstructuredReference=陈耕耘,李圣辰,邵曦,等.基于迁移学习与强化学习的自动音频标注系统[J].复旦学报(自然科学版),2022,61(5):520-526., articleTitle=基于迁移学习与强化学习的自动音频标注系统, refAbstract=null), Reference(id=1322931604754137141, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=6, issue=null, pageStart=1448351, pageEnd=null, url=null, language=null, rfNumber=28, rfOrder=27, authorNames=Anibal J, Huth H, Li M, journalName=Frontiers in Digital Health, refType=null, unstructuredReference=Anibal J,Huth H,Li M,et al.Voice EHR:introducing multimodal audio data for health[J].Frontiers in Digital Health,2024,6:1448351., articleTitle=Voice EHR:introducing multimodal audio data for health, refAbstract=null), Reference(id=1322931604858994742, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=7, issue=null, pageStart=208, pageEnd=null, url=null, language=null, rfNumber=29, rfOrder=28, authorNames=Berisha V, Liss J M, journalName=NPJ Digital Medicine, refType=null, unstructuredReference=Berisha V,Liss J M.Responsible development of clinical speech AI:bridging the gap between clinical research and technology[J].NPJ Digital Medicine,2024,7:208., articleTitle=Responsible development of clinical speech AI:bridging the gap between clinical research and technology, refAbstract=null), Reference(id=1322931605127430199, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2025, volume=42, issue=1, pageStart=21, pageEnd=24, url=null, language=null, rfNumber=30, rfOrder=29, authorNames=窦艳华, 罗宇, 南江, journalName=军事护理, refType=null, unstructuredReference=窦艳华,罗宇,南江,等.护理组学的发展现状及展望[J].军事护理,2025,42(1):21-24., articleTitle=护理组学的发展现状及展望, refAbstract=null), Reference(id=1322931605198733368, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2025, volume=38, issue=10, pageStart=1233, pageEnd=1239, url=null, language=null, rfNumber=31, rfOrder=30, authorNames=单锶楷, 韩舒羽, 王文霞, journalName=中国医学伦理学, refType=null, unstructuredReference=单锶楷,韩舒羽,王文霞,等.语音生物标记物在医疗应用中的伦理问题与应对策略研究[J].中国医学伦理学,2025,38(10):1233-1239., articleTitle=语音生物标记物在医疗应用中的伦理问题与应对策略研究, refAbstract=null), Reference(id=1322931605530083385, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=26, issue=6, pageStart=56, pageEnd=64, url=null, language=null, rfNumber=32, rfOrder=31, authorNames=韩舒羽, 王文霞, 杨宇帆, journalName=中国工程科学, refType=null, unstructuredReference=韩舒羽,王文霞,杨宇帆,等.老年人智慧医疗领域语音生物标记物应用研究[J].中国工程科学,2024,26(6):56-64., articleTitle=老年人智慧医疗领域语音生物标记物应用研究, refAbstract=null), Reference(id=1322931605601386554, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, doi=null, pmid=null, pmcid=null, year=2024, volume=179, issue=null, pageStart=108844, pageEnd=null, url=null, language=null, rfNumber=33, rfOrder=32, authorNames=Chen Z, Liang N, Li H Y, journalName=Computers in Biology and Medicine, refType=null, unstructuredReference=Chen Z,Liang N,Li H Y,et al.Exploring explainable AI features in the vocal biomarkers of lung disease[J].Computers in Biology and Medicine,2024,179:108844., articleTitle=Exploring explainable AI features in the vocal biomarkers of lung disease, refAbstract=null)], funds=null, companyList=[AuthorCompany(id=1322931595543446515, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, xref=1, ext=[AuthorCompanyExt(id=1322931595572806644, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Changchun University of Chinese Medicine, Jilin 130117 China), AuthorCompanyExt(id=1322931595581195253, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1长春中医药大学,吉林 130117)])], figs=null, attaches=null, journal=Journal(id=1220037649855897604, delFlag=0, nameCn=护理研究, nameEn=Chinese Nursing Research, nameHistory1=null, nameHistory2=null, issn=1009-6493, eissn=null, cn=14-1272/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=5ND/w5RQYz//x8ucn+e6Vw==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Nursing Research, journalRemark=null, publicationField=null, createdTime=1768809242933, updatedTime=1789628561524, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=H, firstLetterEn=H, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=5ND/w5RQYz//x8ucn+e6Vw==, picEn=vXneBBf6WfTz/ls4yy3nnA==, jcr=null, cjcr=null, exts=[JournalExt(id=1307360202571928186, language=CN, name=护理研究, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1789628561871, updatedTime=1789628561871, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://journal.ids.fzyun.cn/auth/realms/journal/protocol/openid-connect/auth?client_id=journal-sxyxqks-author&redirect_uri=https%3A%2F%2Fgj.sxyxqks.com%2Foauth%2Fcallback&response_type=code&scope=phone+openid+email+profile&state=1de4c13f-4807-4ea4-8d8a-5, submissionEditorUrl=https://journal.ids.fzyun.cn/auth/realms/journal/protocol/openid-connect/auth?client_id=journal-sxyxqks-author&redirect_uri=https%3A%2F%2Fgj.sxyxqks.com%2Foauth%2Fcallback&response_type=code&scope=phone+openid+email+profile&state=321a724c-d51d-4f08-a85e-2, submissionReviewUrl=https://journal.ids.fzyun.cn/auth/realms/journal/protocol/openid-connect/auth?client_id=journal-sxyxqks-author&redirect_uri=https%3A%2F%2Fgj.sxyxqks.com%2Foauth%2Fcallback&response_type=code&scope=phone+openid+email+profile&state=dadec7f2-d93c-4f73-8f97-e, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1307360202618065531, language=EN, name=Chinese Nursing Research, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1789628561882, updatedTime=1789628561882, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://journal.ids.fzyun.cn/auth/realms/journal/protocol/openid-connect/auth?client_id=journal-sxyxqks-author&redirect_uri=https%3A%2F%2Fgj.sxyxqks.com%2Foauth%2Fcallback&response_type=code&scope=phone+openid+email+profile&state=1de4c13f-4807-4ea4-8d8a-5, submissionEditorUrl=https://journal.ids.fzyun.cn/auth/realms/journal/protocol/openid-connect/auth?client_id=journal-sxyxqks-author&redirect_uri=https%3A%2F%2Fgj.sxyxqks.com%2Foauth%2Fcallback&response_type=code&scope=phone+openid+email+profile&state=321a724c-d51d-4f08-a85e-2, submissionReviewUrl=https://journal.ids.fzyun.cn/auth/realms/journal/protocol/openid-connect/auth?client_id=journal-sxyxqks-author&redirect_uri=https%3A%2F%2Fgj.sxyxqks.com%2Foauth%2Fcallback&response_type=code&scope=phone+openid+email+profile&state=dadec7f2-d93c-4f73-8f97-e, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1220038315760373764, websiteList=[Website(id=1220043903038837076, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1220038315760373764, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/hlyj/CN, language=CN, createTime=1768810733804, createBy=18614031015, updateTime=1768811130580, updateBy=18614031015, name=护理研究-中文, tplId=1146099689490845704, title=护理研究, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1228001613021904925, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903038837076, code=articleTextType, value=kx, createTime=1770707999711, updateTime=1770707999711, creator=18614031015, updator=18614031015), WebsiteProps(id=1228001613005127706, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903038837076, code=banner, value=null, createTime=1770707999707, updateTime=1770707999707, creator=18614031015, updator=18614031015), WebsiteProps(id=1228001613038682144, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903038837076, code=grayFlag, value=0, createTime=1770707999715, updateTime=1770707999715, creator=18614031015, updator=18614031015), WebsiteProps(id=1228001613000933401, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903038837076, code=logo, value=https://castjournals.cast.org.cn/joweb/hlyj/CN/file/pic?fileId=pB29yYO+7WdTp0HLQ4KSzg==, createTime=1770707999706, updateTime=1770707999706, creator=18614031015, updator=18614031015), WebsiteProps(id=1228001613047070754, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903038837076, code=minRunFlag, value=0, createTime=1770707999717, updateTime=1770707999717, creator=18614031015, updator=18614031015), WebsiteProps(id=1228001613017710620, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903038837076, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/hlyj/CN/file/pic, createTime=1770707999710, updateTime=1770707999710, creator=18614031015, updator=18614031015), WebsiteProps(id=1228001613042876449, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903038837076, code=silenceFlag, value=0, createTime=1770707999716, updateTime=1770707999716, creator=18614031015, updator=18614031015), WebsiteProps(id=1228001613013516315, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903038837076, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1770707999709, updateTime=1770707999709, creator=18614031015, updator=18614031015), WebsiteProps(id=1228001613026099230, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903038837076, code=themeColor, value=null, createTime=1770707999712, updateTime=1770707999712, creator=18614031015, updator=18614031015), WebsiteProps(id=1228001613034487839, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903038837076, code=themeStyle, value=null, createTime=1770707999714, updateTime=1770707999714, creator=18614031015, updator=18614031015)]), Website(id=1220043903097557352, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1220038315760373764, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/hlyj/EN, language=EN, createTime=1768810733819, createBy=18614031015, updateTime=1768811154181, updateBy=18614031015, name=护理研究-英文, tplId=1146101810881728533, title=Chinese Nursing Research, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1220045841042166147, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903097557352, code=articleTextType, value=kx, createTime=1768811195860, updateTime=1768811195860, creator=18614031015, updator=18614031015), WebsiteProps(id=1220045841017000320, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903097557352, code=banner, value=null, createTime=1768811195854, updateTime=1768811195854, creator=18614031015, updator=18614031015), WebsiteProps(id=1220045841063137670, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903097557352, code=grayFlag, value=0, createTime=1768811195865, updateTime=1768811195865, creator=18614031015, updator=18614031015), WebsiteProps(id=1220045841008611711, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903097557352, code=logo, value=https://castjournals.cast.org.cn/joweb/hlyj/EN/file/pic?fileId=pB29yYO+7WdTp0HLQ4KSzg==, createTime=1768811195852, updateTime=1768811195852, creator=18614031015, updator=18614031015), WebsiteProps(id=1220045841075720584, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903097557352, code=minRunFlag, value=0, createTime=1768811195868, updateTime=1768811195868, creator=18614031015, updator=18614031015), WebsiteProps(id=1220045841033777538, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903097557352, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/hlyj/EN/file/pic, createTime=1768811195858, updateTime=1768811195858, creator=18614031015, updator=18614031015), WebsiteProps(id=1220045841071526279, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903097557352, code=silenceFlag, value=0, createTime=1768811195867, updateTime=1768811195867, creator=18614031015, updator=18614031015), WebsiteProps(id=1220045841025388929, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903097557352, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1768811195857, updateTime=1768811195857, creator=18614031015, updator=18614031015), WebsiteProps(id=1220045841046360452, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903097557352, code=themeColor, value=null, createTime=1768811195861, updateTime=1768811195861, creator=18614031015, updator=18614031015), WebsiteProps(id=1220045841054749061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1220043903097557352, code=themeStyle, value=null, createTime=1768811195863, updateTime=1768811195863, creator=18614031015, updator=18614031015)])], journalTitle=护理研究, weixinUrl=null, journalUrl=https://www.hlyjzz.com/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Nursing Research, journalPhotoCn=5ND/w5RQYz//x8ucn+e6Vw==, journalPhotoEn=vXneBBf6WfTz/ls4yy3nnA==, journalFirstLetter=H, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/hlyj/CN/10.12102/j.issn.1009-6493.2026.12.026, detailUrlEn=https://castjournals.cast.org.cn/joweb/hlyj/EN/10.12102/j.issn.1009-6493.2026.12.026, pdfUrlCn=https://castjournals.cast.org.cn/joweb/hlyj/CN/PDF/10.12102/j.issn.1009-6493.2026.12.026, pdfUrlEn=https://castjournals.cast.org.cn/joweb/hlyj/EN/PDF/10.12102/j.issn.1009-6493.2026.12.026, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=1, orderTime=1782316800000, fullTextJson=null, articleText=null, reference=null)
收藏切换
语音生物标记物在慢性病病人管理中的应用进展
收藏切换
何晓菲 , 矫玉晓 , 马璐璐 , 张博 , 朱蓝玉 *, *
护理研究 | 科研综述 2026,40(12): 2185-2188
收起
收藏切换
护理研究 |科研综述 2026 , 40 (12) : 2185 -2188
语音生物标记物在慢性病病人管理中的应用进展
全屏
[Author(id=1322931595920933879, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322931596059345913, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931595920933879, language=EN, stringName=Xiaofei HE, firstName=Xiaofei, middleName=null, lastName=HE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1Changchun University of Chinese Medicine, Jilin 130117 China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322931596315198458, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931595920933879, language=CN, stringName=何晓菲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1长春中医药大学,吉林 130117, bio={"content":"

何晓菲,护士,硕士研究生在读

"}, bioImg=null, bioContent=

何晓菲,护士,硕士研究生在读

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322931595543446515, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, xref=1, ext=[AuthorCompanyExt(id=1322931595572806644, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Changchun University of Chinese Medicine, Jilin 130117 China), AuthorCompanyExt(id=1322931595581195253, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1长春中医药大学,吉林 130117)])]), Author(id=1322931596394890236, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322931596487164926, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931596394890236, language=EN, stringName=Yuxiao JIAO, firstName=Yuxiao, middleName=null, lastName=JIAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1Changchun University of Chinese Medicine, Jilin 130117 China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322931596571051007, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931596394890236, language=CN, stringName=矫玉晓, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1长春中医药大学,吉林 130117, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322931595543446515, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, xref=1, ext=[AuthorCompanyExt(id=1322931595572806644, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Changchun University of Chinese Medicine, Jilin 130117 China), AuthorCompanyExt(id=1322931595581195253, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1长春中医药大学,吉林 130117)])]), Author(id=1322931596663324672, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322931596814319618, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931596663324672, language=EN, stringName=Lulu MA, firstName=Lulu, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1Changchun University of Chinese Medicine, Jilin 130117 China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322931596902400003, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931596663324672, language=CN, stringName=马璐璐, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1长春中医药大学,吉林 130117, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322931595543446515, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, xref=1, ext=[AuthorCompanyExt(id=1322931595572806644, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Changchun University of Chinese Medicine, Jilin 130117 China), AuthorCompanyExt(id=1322931595581195253, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1长春中医药大学,吉林 130117)])]), Author(id=1322931598592704518, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322931598697562120, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931598592704518, language=EN, stringName=Bo ZHANG, firstName=Bo, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1Changchun University of Chinese Medicine, Jilin 130117 China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322931598773059593, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931598592704518, language=CN, stringName=张博, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1长春中医药大学,吉林 130117, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322931595543446515, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, xref=1, ext=[AuthorCompanyExt(id=1322931595572806644, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Changchun University of Chinese Medicine, Jilin 130117 China), AuthorCompanyExt(id=1322931595581195253, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1长春中医药大学,吉林 130117)])]), Author(id=1322931598869528587, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=13588836@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322931598961803277, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931598869528587, language=EN, stringName=Lanyu ZHU, firstName=Lanyu, middleName=null, lastName=ZHU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=1Changchun University of Chinese Medicine, Jilin 130117 China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322931599033106446, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, authorId=1322931598869528587, language=CN, stringName=朱蓝玉, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=*, *, address=1长春中医药大学,吉林 130117, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322931595543446515, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, xref=1, ext=[AuthorCompanyExt(id=1322931595572806644, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Changchun University of Chinese Medicine, Jilin 130117 China), AuthorCompanyExt(id=1322931595581195253, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322931592204780528, companyId=1322931595543446515, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1长春中医药大学,吉林 130117)])])]
何晓菲, 矫玉晓, 马璐璐, 张博, 朱蓝玉*, *
作者信息
  • 1长春中医药大学,吉林 130117
通讯作者:
朱蓝玉,E-mail:
ZHU Lanyu, E-mail:
作者简介:

何晓菲,护士,硕士研究生在读

Progress on application of vocal biomarkers in the management of patients with chronic diseases
Xiaofei HE, Yuxiao JIAO, Lulu MA, Bo ZHANG, Lanyu ZHU
Affiliations
  • 1Changchun University of Chinese Medicine, Jilin 130117 China
出版时间: 2026-06-25 doi: 10.12102/j.issn.1009-6493.2026.12.026
文章导航
收藏切换

阐述了语音生物标记物的概念、类型,综述了语音生物标记物在慢性病管理中的应用、挑战及展望,以期为加快精准化、个性化的慢性病管理提供参考。

慢性病  /  语音生物标记物  /  健康管理  /  人工智能  /  综述

This study expounded the concept and types of vocal biomarkers.It reviewed the application,challenges and prospects of vocal biomarkers in chronic disease management,so as to provide a reference for accelerating the development of precise and personalized chronic disease management.

chronic diseases  /  vocal biomarkers  /  health management  /  artificial intelligence  /  review
何晓菲, 矫玉晓, 马璐璐, 张博, 朱蓝玉. 语音生物标记物在慢性病病人管理中的应用进展. 护理研究, 2026 , 40 (12) : 2185 -2188 . DOI: 10.12102/j.issn.1009-6493.2026.12.026
Xiaofei HE, Yuxiao JIAO, Lulu MA, Bo ZHANG, Lanyu ZHU. Progress on application of vocal biomarkers in the management of patients with chronic diseases[J]. Chinese Nursing Research, 2026 , 40 (12) : 2185 -2188 . DOI: 10.12102/j.issn.1009-6493.2026.12.026
随着人口老龄化和预期寿命的增加,预计到2040年,我国老年人口将达4.02亿人,其中75%以上老年人患有慢性病[1]。由于慢性病病因复杂、潜伏期长、病程长、控制率低和经济负担重,其已成为一个严峻的公共卫生问题,严重威胁个人健康并阻碍社会经济发展[2]。因此,如何有效预防和管理慢性病,进一步满足病人精准化和个性化的医疗需求成为亟须解决的重要问题。然而,现有慢性病管理模式具有滞后性,其诊断主要依赖病人主动就医,并通过标准化量表和仪器检查进行评估,导致病情数据采集不连续且主观性强,易错过疾病的最佳干预时机。近年来,随着人工智能和机器学习算法的快速发展,语音生物标记物作为一种对疾病特征参数进行识别和分析的数字信号处理技术,通过对声学和语言特征进行建模,凭借其非侵入性、易操作且客观测量的优势,能够准确、迅速地模拟更多的数据点,可提前筛查和预测异常疾病状态的发生[3-4],为医护人员和病人提供了一种更积极、主动管理疾病的新模式,在慢性病病人健康管理中展现出广阔的应用前景。目前,该技术已被广泛应用于神经系统疾病[5]、心血管疾病[6]及呼吸系统疾病[7]等领域,为慢性病病人的健康管理提供了新思路和新方法。本研究对语音生物标记物在慢性病病人管理中的应用进行综述,旨在促进护理学科与多学科的深度融合,为推动精准护理的临床实践和落地转化提供参考。
语音生物标记物是指通过机器学习和深度学习算法,对人体发声的语音信号特征进行检测和量化分析,从而捕捉特异性生物语音信号,以识别个体的生理、病理及心理健康相关模式是否异常[8]。语音生物标记物之所以能作为慢性病管理的有效工具,是因为语音的产生是一个复杂、多阶段的生理过程,依赖神经运动、呼吸系统、心血管系统和精神状态等的精准协调。研究表明,上述任何环节的功能异常都可能引发音调、语速或频谱等语音学参数的变异[4]。而这些细微的变化都可以通过语音生物标记物技术进行捕捉和分析,从而实现疾病的早期预警和干预。随着自然语言处理技术和大语言模型的发展,其挖掘出的语音特征参数更加丰富和精准,语音生物标记物作为一种易操作、低成本且支持远程访问的数字技术,为慢性病的管理提供了无创、高效率及高质量的技术支持[7]。
根据语音来源和特征的不同,语音生物标记物可分为以下3类[4-5]。1)声学特征:指声带振荡所产生的声音信号,通过数字语音处理技术提取的语音物理属性,这些特征能够反映发声器官的生理状态及其功能异常,包括基频、共振峰频率、能量、频谱等。2)语言学特征:指由认知和语言知识驱动产生的元音和辅音的构音运动,与语言结构和内容相关,这些特征能够反映个体的认知功能和语言能力,包括音节、词汇、语法和语义特征等。3)副语言特征:指语音中非语言内容的信息,主要反映个体的生理状态和情感变化,包括呼吸、语速、音高和音量等。
研究表明,与传统的感知分析、评定量表和仪器检查相比,用于语音数据采集和分析的数字技术能为慢性病病人提供更准确和个性化的疾病筛查和诊断[9]。Saab等[10]通过提取病人标准化元音、单词和句子的语音数据,开发了一种自动化吞咽障碍筛查的概念验证模型,结果发现,该工具在吞咽障碍筛查中的灵敏度和特异性分别为89%和79%,可有效推动吞咽障碍筛查的普及化,减轻医护人员的工作负荷,提高护理干预的有效性。Mahon等[11]研究发现,更高的抖动、更低的基频、更多的语音中断与记忆力的显著下降相关,这为早期诊断认知障碍或筛查阿尔茨海默病高危因素、高危人群提供了一种有前景的方法。研究表明,基于上下呼吸道的音频、声学和声音的数字生物标记物,方便医护人员早期筛查和诊断呼吸系统疾病病人,为其提供连续性、高质量的护理服务[7]。Pusil等[12]研究强调了哭泣分析作为支持早期孤独症筛查和诊断的语音生物标记物的潜力,其特定的声学特征,如基频、发声、持续时间、振幅和语音质量等是区分正常发育婴儿、孤独症婴儿、孤独症高风险与低风险的可靠指标。尽管语音生物标记物在病人病情筛查及诊断方面具有显著优势,但由于使用环境不同、文化背景差异以及个体语言差异可能会导致数据集不平衡,影响模型的准确性和可靠性,进而限制了其在不同人群中的适用性,不利于模型的大规模泛化。
语音生物标记物可基于获得的语音声学特征生成智能化的预测模型,用于动态预测慢性病病人的疾病进展,辅助临床决策。Amini等[13]利用自然语言处理技术和机器学习方法,开发了一种基于语音的自动化预测模型,用于预测轻度认知障碍在6年内进展为阿尔茨海默病的风险,结果表明,该模型的准确率为78.5%,灵敏度为81.1%,显示出良好的疾病风险预测效果,推动了远程护理指导的发展。同时,语音生物模型能有效预测认知功能下降,并识别和区分不同程度的认知障碍病人[14],有利于为医护人员提供实时的风险评估,优化护理干预方案,预防不良结局的发生。Kim等[15]通过提取社区老年人2 min图片描述任务的语音数据,探讨音高、响度和梅尔频率倒谱系数和虚弱程度之间的关系,构建了症状学和衰弱程度的预测模型,医护人员可通过线上进行健康特征的识别,缩短了病人线下就医的时间,节省了人力成本,有利于医护资源的合理配置。虽然语音生物标记物在疾病风险预测方面具有潜在的使用价值,但目前在语音特征与疾病潜在机制、健康结局之间的研究较少,且医护人员在语音技术方面的知识背景和技能水平不足,在一定程度上限制了研究的广度和深度。
语音生物标记物通过连续监测病人语音特征的变化和生物学指标演进,有效识别疾病发展趋势,有利于支持医护人员为慢性病病人制定个性化、精准性的症状管理方案[16]。Schöbi等[17]研究评估了一种监测心力衰竭病人并预防失代偿的语音生物标志物,提取了68例急性心力衰竭病人和36例稳定性心力衰竭病人的语音节奏速率、停顿比、平均停顿时长和平均发音时长4个与停顿时间相关的语音特征,结果发现,与稳定性心力衰竭病人相比,急性心力衰竭病人的语音停顿比增加了14.9%,而停顿比与N末端B型利钠肽原(NT-proBNP)呈正相关。医护人员可借助此类蛋白组学和语音标志物的联合,尽早识别心力衰竭失代偿病人,提前制定相关症状的预防措施,以减少不良健康结局的发生。Fagherazzi等[18]基于人工智能模型,开发了一个提取新型冠状病毒感染(COVID-19)相关症状的语音生物标志物,以高效、精准监测COVID-19相关症状的缓解情况,发现舌黏膜上血管紧张素转换酶2(ACE2)受体表达、白细胞介素-6水平(IL-6)升高均与语音生成障碍有关,可揭示相应症状表征下的病情变化,以支持症状应对策略的即时调整,提高长期照护的有效性。然而,语音生物标记物的使用依赖大规模数据的收集、存储和分析等,这些数据中包含了病人的身份信息、生理指标等隐私信息,存在数据泄露和未经授权访问的潜在风险。
语音生物标记物能高效捕捉不同心理障碍和症状的声学特征,为间接评估和追踪病人的心理健康状态提供了有利的数字健康支持[19]。研究表明,抑郁症病人的语音呈现出更加缓慢、低沉和单调的特点,在使用语音生物标记物分析时,表现出基频水平的降低、较慢的音调变化和较低的音调[20-22]。对于精神分裂症病人而言,其语音表现为口语时间比例降低、语速降低和停顿持续时间增加[23]。焦虑病人呈现出变异性显著增高的颤音、闪烁和基频的声学特征[24]。为此,Larsen等[25]一项针对104例门诊精神科病人的前瞻性队列研究,验证了基于智能手机的30 s语音样本提取出的心理健康声学生物标志物(MFVB)在病人中的有效性,发现MFVB能够根据病人心理健康症状严重程度的风险水平进行分层评估,为临床诊疗提供了个性化健康洞察,有利于改善病人的心理健康风险及预后状况。Riad等[26]开发了一个基于语音标志物的全自动机器学习系统,以检测该系统在普通人群中多方面心理健康评估的潜力,发现该系统能有效识别超过临床阈值的抑郁、失眠及综合疲劳症状,并预测相关症状的严重程度。语音生物标记物的普及不仅提高了医护人员评估心理健康问题的准确性,也为筛查心理健康问题或症状的迹象提供了重要参考。
强化训练数据集是指通过一系列技术和方法,提升数据集的质量、多样性和代表性,从而为机器学习模型提供更可靠、更全面的训练基础[27]。强化训练数据集的准确性取决于数据异质性和模型泛化性,解决这两大挑战对于语音生物标记物的开发和应用至关重要。在数据异质性方面,引入多模态健康音频数据[28],包括慢性病病人的多音频数据(如语音、呼吸音、心音等)以及相关的非音频数据(如文本、生理指标、影像数据等),提高数据的整合利用。同时,收集多样化、高质量的数据集,涵盖不同慢性病病人年龄、性别、语言和环境条件下的语音样本,增加训练数据的准确性。在模型泛化性方面,为适应各种环境,新开发的模型需要在未用于训练阶段的独立数据集上进行严格的测试和验证,V3框架为其提供了一个结构性的方法,包括验证、分析验证和临床验证3个评估步骤[29]。验证确保了声学数据质量在其所处环境中的保真度,分析验证确认语音参数与其行为和生理指标等关系的可靠性,临床验证通过对比已有的临床经验或干预措施验证语音参数的有效性。通过连续性的评估维持模型的稳定性和敏感性,从而保证语音模型的持续泛化,为慢性病病人的健康管理提供技术支持。
为充分发挥语音生物标记物在精准慢性病健康管理中的作用,加强护理组学、声学、语言学、计算机科学及信息科学等多学科资源的深度融合[30],通过多模态数据,构建以症状表征为核心的护理路径,推进语音生物标记物与健康结局(如疾病进展、治疗效果、生活质量)机制的关系研究,为声学评估提供补充,捕捉语音中病情变化的复杂特征,优化和升级模型算法的精确性,为精准护理的临床研究和实践赋能[8]。定期举办研讨会、培训会,提升护理人员数智化水平和症状科学知识背景,加强护士对多组学技术和信息化技术的整合,提高护理复合型人才队伍的领导竞争力,以推进智慧慢性病管理新模式的转变。
声音作为智能语音技术的研究对象,其语音隐私和数据的合理规范使用,对于满足庞大的慢性病病人的健康管理需求至关重要。在信息安全体系建设方面,应制定严格、完善的语音生物标记物研究的数据访问制度和保护政策,加强数据监督和管理部门的建设,明确数据收集、模型开发、临床验证等各方的权责界限,并对语音生物标记物研究的全流程数据进行监督,确保语音数据的安全性和隐私性[31]。在学科资源整合方面,积极探索跨学科团队合作,推动多平台、多模态资源整合,开发高效的数据加密、匿名化和隐私保护技术,确保技术既科学、合理又符合临床需求[32]。在技术方面,利用联邦学习、差分隐私等先进技术[33],在保护用户隐私的前提下实现数据的有效利用,为语音生物标记物的研究和应用提供坚实的技术支持。
语音生物标记物作为一种无创、便捷的技术手段,通过对病人多维语音数据特征的实时追踪,实现针对不同病人的病情筛查及诊断、疾病风险预测、精准化症状管理等,为慢性病病人管理提供了更高效、精准的护理模式。但其发展中仍存在数据准确性与可靠性低、人才资源短缺、数据隐私和安全威胁等挑战。未来应加强语音数据集的质量、隐私与安全管理等,推进护理学科与多学科跨领域的纵深研究,从而为慢性病病人提供更加精准化、高效化和个性化的医疗护理服务。

参考文献 引证文献
排序方式:
1
Chen J D,Zhang F,Zhang Y,et al.Trajectories network analysis of chronic diseases among middle-aged and older adults:evidence from the China health and retirement longitudinal study(CHARLS)[J].BMC Public Health,2024,24(1):559.
2
Shao Y J,Duan X C,Xu X J,et al.Latent profile and determinants of self-management behaviors among older adult patients with chronic diseases:a cross-sectional study[J].Frontiers in Public Health,2025,13:1506545.
3
王文霞,韩舒羽,单锶楷,等.美国国立卫生研究院对语音生物标记物相关科研资助项目分析[J].军事护理,2024,41(11):5-8.
4
Sara J D S,Orbelo D,Maor E,et al.Guess what we can hear-novel voice biomarkers for the remote detection of disease[J].Mayo Clinic Proceedings,2023,98(9):1353-1375.
5
Bowden M,Beswick E,Tam J,et al.A systematic review and narrative analysis of digital speech biomarkers in motor neurone disease[J].Digital Medicine,2023,6:228.
6
Okada K,Mizuguchi D,Omiya Y,et al.Clinical utility of machine learning-derived vocal biomarkers in the management of heart failure[J].Circulation Reports,2024,6(8):303-312.
7
Kapetanidis P,Kalioras F,Tsakonas C,et al.Respiratory diseases diagnosis using audio analysis and artificial intelligence:a systematic review[J].Sensors,2024,24(4):1173.
8
Oreskovic J,Kaufman J,Fossat Y.Impact of audio data compression on feature extraction for vocal biomarker detection:validation study[J].JMIR Biomedical Engineering,2024,9:e56246.
9
Tröger J,Dörr F,Schwed L,et al.An automatic measure for speech intelligibility in dysarthrias-validation across multiple languages and neurological disorders[J].Frontiers in Digital Health,2024,6:1440986.
10
Saab R,Balachandar A,Mahdi H,et al.Machine-learning assisted swallowing assessment:a deep learning-based quality improvement tool to screen for post-stroke dysphagia[J].Frontiers in Neuroscience,2023,17:1302132.
11
Mahon E,Lachman M E.Voice biomarkers as indicators of cognitive changes in middle and later adulthood[J].Neurobiology of Aging,2022,119:22-35.
12
Pusil S,Laguna A,Chino B,et al.Early identification of autism using cry analysis:a systematic review and meta-analysis of retrospective and prospective studies[J].Journal of Autism and Developmental Disorders,2025.
13
Amini S,Hao B R,Yang J M,et al.Prediction of Alzheimer's disease progression within 6 years using speech:a novel approach leveraging language models[J].Alzheimer's & Dementia,2024,20(8):5262-5270.
14
García-Gutiérrez F,Alegret M,Marquié M,et al.Unveiling the sound of the cognitive status:machine learning-based speech analysis in the Alzheimer's disease spectrum[J].Alzheimer's Research & Therapy,2024,16(1):26.
15
Kim T,Choi J Y,Ko M J,et al.Development and validation of a machine learning method using vocal biomarkers for identifying frailty in community-dwelling older adults:cross-sectional study[J].JMIR Medical Informatics,2025,13:e57298.
16
杨建梅,林桂如,欧婉仪,等.多组学技术在临床护理研究中的应用进展[J].中华护理杂志,2024,59(16):2044-2048.
17
Schöbi D,Zhang Y P,Kehl J,et al.Evaluation of speech and pause alterations in patients with acute and chronic heart failure[J].Journal of the American Heart Association,2022,11(21):e027023.
18
Fagherazzi G,Zhang L,Elbéji A,et al.A voice-based biomarker for monitoring symptom resolution in adults with COVID-19:findings from the prospective predi-COVID cohort study[J].PLoS Digital Health,2022,1(10):e0000112.
19
Briganti G,Lechien J R.Voice quality as digital biomarker in bipolar disorder:a systematic review[J].Journal of Voice,2025.
20
Di Y Z,Rahmani E,Mefford J,et al.Unraveling the associations between voice pitch and major depressive disorder:a multisite genetic study[J].Molecular Psychiatry,2025,30(6):2686-2695.
21
Mazur A,Costantino H,Tom P,et al.Evaluation of an AI-based voice biomarker tool to detect signals consistent with moderate to severe depression[J].Annals of Family Medicine,2025,23(1):60-65.
22
Kiss G,Vicsi K.Mono- and multi-lingual depression prediction based on speech processing[J].International Journal of Speech Technology,2017,20(4):919-935.
23
Parola A,Simonsen A,Bliksted V,et al.Voice patterns in schizophrenia:a systematic review and Bayesian meta-analysis[J].Schizophrenia Research,2020,216:24-40.
24
Low D M,Bentley K H,Ghosh S S.Automated assessment of psychiatric disorders using speech:a systematic review[J].Laryngoscope Investigative Otolaryngology,2020,5(1):96-116.
25
Larsen E,Murton O,Song X Y,et al.Validating the efficacy and value proposition of mental fitness vocal biomarkers in a psychiatric population:prospective cohort study[J].Frontiers in Psychiatry,2024,15:1342835.
26
Riad R,Denais M,de Gennes M,et al.Automated speech analysis for risk detection of depression,anxiety,insomnia,and fatigue:algorithm development and validation study[J].Journal of Medical Internet Research,2024,26:e58572.
27
陈耕耘,李圣辰,邵曦,等.基于迁移学习与强化学习的自动音频标注系统[J].复旦学报(自然科学版),2022,61(5):520-526.
28
Anibal J,Huth H,Li M,et al.Voice EHR:introducing multimodal audio data for health[J].Frontiers in Digital Health,2024,6:1448351.
29
Berisha V,Liss J M.Responsible development of clinical speech AI:bridging the gap between clinical research and technology[J].NPJ Digital Medicine,2024,7:208.
30
窦艳华,罗宇,南江,等.护理组学的发展现状及展望[J].军事护理,2025,42(1):21-24.
31
单锶楷,韩舒羽,王文霞,等.语音生物标记物在医疗应用中的伦理问题与应对策略研究[J].中国医学伦理学,2025,38(10):1233-1239.
32
韩舒羽,王文霞,杨宇帆,等.老年人智慧医疗领域语音生物标记物应用研究[J].中国工程科学,2024,26(6):56-64.
33
Chen Z,Liang N,Li H Y,et al.Exploring explainable AI features in the vocal biomarkers of lung disease[J].Computers in Biology and Medicine,2024,179:108844.
2026年第40卷第12期
8
3
引用本文
BibTeX
文章信息
doi: 10.12102/j.issn.1009-6493.2026.12.026
  • 接收时间:2025-05-12
  • 首发时间:2026-10-30
  • 出版时间:2026-06-25
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期:2025-05-12
  • 修回日期:2026-06-03
基金
作者信息
    1长春中医药大学,吉林 130117

通讯作者:

朱蓝玉,E-mail:
ZHU Lanyu, E-mail:
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/hlyj/CN/10.12102/j.issn.1009-6493.2026.12.026
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏