Article(id=1322168781674238049, tenantId=1146029695717560320, journalId=1220038315760373764, issueId=1322168387082502716, articleNumber=null, orderNo=null, doi=10.12102/j.issn.1009-6493.2026.06.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1741449600000, receivedDateStr=2025-03-09, revisedDate=1770566400000, revisedDateStr=2026-02-09, acceptedDate=null, acceptedDateStr=null, onlineDate=1793159202258, onlineDateStr=2026-10-28, pubDate=1774368000000, pubDateStr=2026-03-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793159202258, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793159202258, creator=13701087609, updateTime=1793159202258, updator=13701087609, issue=Issue{id=1322168387082502716, tenantId=1146029695717560320, journalId=1220038315760373764, year='2026', volume='40', issue='6', pageStart='881', pageEnd='1056', issueExtLink='null', onlineDate='null', pubDate='1774368000000', pubDateStr='2026-03-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793159108180, creator='13701087609', updateTime=1793159108180, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=906, endPage=915, ext={EN=ArticleExt(id=1322168783469400162, articleId=1322168781674238049, tenantId=1146029695717560320, journalId=1220038315760373764, language=EN, title=Longitudinal study of core symptom clusters in postoperative breast cancer patients undergoing chemotherapy based on network analysis, columnId=1220689484526572183, journalTitle=Chinese Nursing Research, columnName=Original Articles, runingTitle=null, highlight=null, articleAbstract=
Objective To construct a network model of symptom clusters and quality of life in postoperative breast cancer patients undergoing chemotherapy.To identify the core symptom clusters and the core domains of quality of life,and to determine the predictive relationships between them,thereby providing scientific guidance for improving patients' quality of life.
Methods A total of 260 breast cancer patients receiving chemotherapy in the oncology department of a tertiary grade A hospital in Yinchuan city were selected as the survey subjects using convenience sampling from May to December 2024.A longitudinal survey was conducted to track their symptoms and quality of life before,during,and after chemotherapy.Data were analyzed using exploratory factor analysis,partial correlation networks,and cross-lagged panel networks.
Results Exploratory factor analysis and partial correlation network analysis revealed four stable symptom clusters in postoperative breast cancer patients undergoing chemotherapy,namely the sickness behavior symptom cluster,the psychosocial symptom cluster,the body image symptom cluster,and the gastrointestinal symptom cluster.The centrality of fatigue symptoms remained the top five across all three periods(rs1=3.02,rs2=4.21,rs3=4.10).Cross-lagged panel network analysis further indicated that the body image symptom cluster was the core symptom cluster in postoperative breast cancer patients undergoing chemotherapy,and physical well-being was the core domain of quality of life.The body image symptom cluster at the previous time point positively predicted physical well-being at the subsequent time point across the three periods(β=1.24 and β=1.49,respectively).
Conclusions The core symptom cluster in postoperative breast cancer patients undergoing chemotherapy is the body image symptom cluster.Physical well-being is the core domain of quality of life.The body image symptom cluster positively predicts improvements in quality of life.Healthcare professionals should develop interventions based on core symptom clusters during treatment to reduce the transmission effect of the body image symptom cluster within the symptom network,indirectly promote the improvement of physical well-being,and thereby enhance quality of life.
, authors=Jiayi ZHANG
1, Xi ZHANG
2, Wanqin TIE
1, Lu PAN
1, Siyu CHEN
1, Qiuyuan SUN
1, Meina YANG
1, authorsList=Jiayi ZHANG, Xi ZHANG, Wanqin TIE, Lu PAN, Siyu CHEN, Qiuyuan SUN, Meina YANG, authorCompany=null, correspAuthors=Xi ZHANG, authorNote=null, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322168787965694067, articleId=1322168781674238049, tenantId=1146029695717560320, journalId=1220038315760373764, language=CN, title=基于网络分析的乳腺癌术后化疗病人核心症状群的纵向研究, columnId=1220689484681761433, journalTitle=护理研究, columnName=科研论著, runingTitle=null, highlight=null, articleAbstract=
目的 构建乳腺癌术后化疗病人症状群与生活质量的网络模型，确定核心症状群与生活质量的核心领域及两者之间的预测关系，为改善病人生活质量提供科学指导。
方法 于2024年5月—12月，采用便利抽样法选取在银川市某三级甲等医院肿瘤内科化疗的260例乳腺癌病人作为调查对象，分别对其化疗前、化疗中、化疗后的症状及生活质量进行追踪调查，使用探索性因子分析、偏相关网络及交叉滞后网络进行数据分析。
结果 探索性因子分析及偏相关网络分析结果显示，乳腺癌术后化疗期间病人存在4个稳定症状群，即疾病行为症状群、精神心理症状群、身体意象症状群及消化道症状群，且乏力症状的中心性在3个时期均排前5位（rs1=3.02，rs2=4.21，rs3=4.10）。交叉滞后网络分析结果进一步表明身体意象症状群为乳腺癌术后化疗期间病人的核心症状群，生理状况是生活质量的核心领域；3个时期中上一时期的身体意象症状群可以正向预测下一时期的生理状况情况（β分别为1.24和1.49）。
结论 乳腺癌术后化疗病人的核心症状群为身体意象症状群，生理状况是生活质量的核心领域，且身体意象症状群能够正向预测生活质量改善情况。医护人员在治疗过程中应基于核心症状群制定干预措施，减少身体意象症状群在症状网络中的传递作用，间接促进生理状况改善，进而提高生活质量。
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1, 张曦
2, *, *, 铁万琴
1, 潘璐
1, 陈思羽
1, 孙秋圆
1, 杨妹娜
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31(5):815-826., articleTitle=积极身体意象的前因后果及其提升策略, refAbstract=null)], funds=null, companyList=[AuthorCompany(id=1322530603782750589, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, xref=1, ext=[AuthorCompanyExt(id=1322530603791139198, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, companyId=1322530603782750589, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1School of Nursing, Ningxia Medical University, Ningxia 750004 China), AuthorCompanyExt(id=1322530603803722111, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, companyId=1322530603782750589, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1宁夏医科大学护理学院，宁夏 750004)]), AuthorCompany(id=1322530603879219584, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, xref=2, ext=[AuthorCompanyExt(id=1322530603887608193, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, companyId=1322530603879219584, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2General Hospital of Ningxia Medical University), AuthorCompanyExt(id=1322530603900191106, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, companyId=1322530603879219584, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2宁夏医科大学总医院)])], figs=[ArticleFig(id=1322530607943500210, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=EN, label=Figure 1, caption=
Network structure of postoperative breast cancer patients before chemotherapy, figureFileSmall=gfIEG/ZXX/z9W8k78zVgyA==, figureFileBig=W22Yn7iZ/qprBBZ0W9JGoQ==, tableContent=null), ArticleFig(id=1322530608014803379, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=CN, label=图1, caption=
乳腺癌术后化疗病人化疗前网络结构, figureFileSmall=gfIEG/ZXX/z9W8k78zVgyA==, figureFileBig=W22Yn7iZ/qprBBZ0W9JGoQ==, tableContent=null), ArticleFig(id=1322530608123855284, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=EN, label=Figure 2, caption=
Network structure of postoperative breast cancer patients during chemotherapy, figureFileSmall=AteYBFEZY3vg2i4GweOxtA==, figureFileBig=VYOoPR/gDSwrITAOWeJk2Q==, tableContent=null), ArticleFig(id=1322530608186769845, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=CN, label=图2, caption=
乳腺癌术后化疗病人化疗中网络结构, figureFileSmall=AteYBFEZY3vg2i4GweOxtA==, figureFileBig=VYOoPR/gDSwrITAOWeJk2Q==, tableContent=null), ArticleFig(id=1322530608245490102, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=EN, label=Figure 3, caption=
Network structure of postoperative breast cancer patients after chemotherapy, figureFileSmall=XSoRsGhKWKFNxLp9an42zQ==, figureFileBig=en+Ng6j+jf63/AcIVa3VvA==, tableContent=null), ArticleFig(id=1322530608316793271, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=CN, label=图3, caption=
乳腺癌术后化疗病人化疗后网络结构, figureFileSmall=XSoRsGhKWKFNxLp9an42zQ==, figureFileBig=en+Ng6j+jf63/AcIVa3VvA==, tableContent=null), ArticleFig(id=1322530608392290744, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=EN, label=Figure 4, caption=
Strength centrality of each node in the symptom networks across three periods, figureFileSmall=oGvbNVEveWPoRoqdYS/B3Q==, figureFileBig=JFceX8zZLEuF1pESV0UdnA==, tableContent=null), ArticleFig(id=1322530608459399609, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=CN, label=图4, caption=
3个时期症状网络各节点的强度中心性, figureFileSmall=oGvbNVEveWPoRoqdYS/B3Q==, figureFileBig=JFceX8zZLEuF1pESV0UdnA==, tableContent=null), ArticleFig(id=1322530608534897082, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=EN, label=Figure 5, caption=
Cross-lagged panel network of stable symptom clusters and quality of life from pre-chemotherapy to during chemotherapy(autoregressive effects removed), figureFileSmall=3HXM6in/HIE5VTV8rRI+vg==, figureFileBig=WZofvZmJvv7s0M1TQr8fQA==, tableContent=null), ArticleFig(id=1322530608602005947, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=CN, label=图5, caption=
化疗前→化疗中乳腺癌病人化疗期间稳定症状群与生活质量的交叉滞后网络（去除自回归）, figureFileSmall=3HXM6in/HIE5VTV8rRI+vg==, figureFileBig=WZofvZmJvv7s0M1TQr8fQA==, tableContent=null), ArticleFig(id=1322530608664920508, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=EN, label=Figure 6, caption=
Cross-lagged panel network between stable symptom clusters and quality of life from during chemotherapy to post-chemotherapy(autoregressive effects removed), figureFileSmall=9SzDkHnRW6g8WNB2UguZvg==, figureFileBig=RLzTWb4GXvGfa80SPd87KQ==, tableContent=null), ArticleFig(id=1322530608736223677, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=CN, label=图6, caption=
化疗中→化疗后的乳腺癌病人化疗期间稳定症状群与生活质量的交叉滞后网络（去除自回归）, figureFileSmall=9SzDkHnRW6g8WNB2UguZvg==, figureFileBig=RLzTWb4GXvGfa80SPd87KQ==, tableContent=null), ArticleFig(id=1322530608794943934, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=EN, label=Figure 7, caption=
Out-EI and in-EI of the cross-lagged panel network of stable symptom clusters and quality of life from pre-chemotherapy to during chemotherapy, figureFileSmall=BmeGtGPhQbtYR/xTODq5Yw==, figureFileBig=fTfKMG+ab1lWhObc9MVy+A==, tableContent=null), ArticleFig(id=1322530608857858495, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=CN, label=图7, caption=
化疗前→化疗中乳腺癌病人化疗期间稳定症状群与生活质量交叉滞后网络的out-EI 和in-EI, figureFileSmall=BmeGtGPhQbtYR/xTODq5Yw==, figureFileBig=fTfKMG+ab1lWhObc9MVy+A==, tableContent=null), ArticleFig(id=1322530608933355968, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=EN, label=Figure 8, caption=
Out-EI and in-EI of the cross-lagged panel network between stable symptom clusters and quality of life from during chemotherapy to post-chemotherapy, figureFileSmall=9D9IQtBXNdj1heu6zJdQFQ==, figureFileBig=zdgHbzczjg5QfLuCCcRaEw==, tableContent=null), ArticleFig(id=1322530609000464833, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=CN, label=图8, caption=
化疗中→化疗后的乳腺癌病人化疗期间稳定症状群与生活质量交叉滞后网络的out-EI 和in-EI, figureFileSmall=9D9IQtBXNdj1heu6zJdQFQ==, figureFileBig=zdgHbzczjg5QfLuCCcRaEw==, tableContent=null), ArticleFig(id=1322530609075962306, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=EN, label=Table 1, caption=
General information of postoperative breast cancer patients undergoing chemotherapy
, figureFileSmall=null, figureFileBig=null, tableContent=
| 项目 | 分类 | 例数 | 构成比（%） | 项目 | 分类 | 例数 | 构成比（%） |
|---|
| 民族 | 汉族 | 212 | 81.5 | 包块部位 | 左侧 | 121 | 46.5 |
| 其他 | 48 | 18.5 | | 右侧 | 139 | 53.5 |
| 文化程度 | 初中及以下 | 164 | 63.1 | 家庭人均月收入 | <1 000元 | 44 | 16.9 |
| 高中或中专 | 59 | 22.7 | | 1 000~<3 000元 | 68 | 26.2 |
| 专科或本科 | 35 | 13.5 | | 3 000~5 000元 | 87 | 33.5 |
| 研究生 | 2 | 0.8 | | >5 000元 | 61 | 23.5 |
| 职业 | 农民 | 112 | 43.1 | 有无子女 | 有 | 251 | 96.5 |
| 在职职工 | 44 | 16.9 | | 无 | 9 | 3.5 |
| 个体工商户 | 37 | 14.2 | 疾病造成的经济负担 | 有 | 178 | 68.5 |
| 退休 | 38 | 14.6 | | 无 | 82 | 31.5 |
| 其他 | 29 | 11.2 | 不良饮食习惯 | 有 | 56 | 21.5 |
| 婚姻状况 | 已婚 | 247 | 95.0 | | 无 | 204 | 78.5 |
| 未婚 | 5 | 1.9 | 夜间睡眠满意度 | 满意 | 92 | 35.4 |
| 离异 | 4 | 1.5 | | 一般 | 106 | 40.8 |
| 丧偶 | 4 | 1.5 | | 不满意 | 62 | 23.8 |
| 家庭居住地 | 城市 | 153 | 58.8 | 病理诊断 | 浸润性非特殊癌 | 242 | 93.1 |
| 农村 | 107 | 41.2 | | 浸润性特殊癌 | 18 | 6.9 |
| 付费方式 | 职工医保 | 158 | 60.8 | TNM分期 | Ⅰ期 | 102 | 39.2 |
| 新型农村合作医疗 | 76 | 29.2 | | Ⅱ期 | 107 | 41.2 |
| 自费 | 26 | 10.0 | | Ⅲ期 | 51 | 19.6 |
), ArticleFig(id=1322530609159848387, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=CN, label=表1, caption=
乳腺癌术后化疗病人的一般资料
, figureFileSmall=null, figureFileBig=null, tableContent=
| 项目 | 分类 | 例数 | 构成比（%） | 项目 | 分类 | 例数 | 构成比（%） |
|---|
| 民族 | 汉族 | 212 | 81.5 | 包块部位 | 左侧 | 121 | 46.5 |
| 其他 | 48 | 18.5 | | 右侧 | 139 | 53.5 |
| 文化程度 | 初中及以下 | 164 | 63.1 | 家庭人均月收入 | <1 000元 | 44 | 16.9 |
| 高中或中专 | 59 | 22.7 | | 1 000~<3 000元 | 68 | 26.2 |
| 专科或本科 | 35 | 13.5 | | 3 000~5 000元 | 87 | 33.5 |
| 研究生 | 2 | 0.8 | | >5 000元 | 61 | 23.5 |
| 职业 | 农民 | 112 | 43.1 | 有无子女 | 有 | 251 | 96.5 |
| 在职职工 | 44 | 16.9 | | 无 | 9 | 3.5 |
| 个体工商户 | 37 | 14.2 | 疾病造成的经济负担 | 有 | 178 | 68.5 |
| 退休 | 38 | 14.6 | | 无 | 82 | 31.5 |
| 其他 | 29 | 11.2 | 不良饮食习惯 | 有 | 56 | 21.5 |
| 婚姻状况 | 已婚 | 247 | 95.0 | | 无 | 204 | 78.5 |
| 未婚 | 5 | 1.9 | 夜间睡眠满意度 | 满意 | 92 | 35.4 |
| 离异 | 4 | 1.5 | | 一般 | 106 | 40.8 |
| 丧偶 | 4 | 1.5 | | 不满意 | 62 | 23.8 |
| 家庭居住地 | 城市 | 153 | 58.8 | 病理诊断 | 浸润性非特殊癌 | 242 | 93.1 |
| 农村 | 107 | 41.2 | | 浸润性特殊癌 | 18 | 6.9 |
| 付费方式 | 职工医保 | 158 | 60.8 | TNM分期 | Ⅰ期 | 102 | 39.2 |
| 新型农村合作医疗 | 76 | 29.2 | | Ⅱ期 | 107 | 41.2 |
| 自费 | 26 | 10.0 | | Ⅲ期 | 51 | 19.6 |
), ArticleFig(id=1322530609239540164, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=EN, label=Table 2, caption=
Incidence and severity of symptoms at different periods in postoperative breast cancer patients undergoing chemotherapy（n=260）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 代号 | 症状 | 化疗前 | 化疗中 | 化疗后 |
|---|
| 发生（%） | 严重程度[M（P25，P75），分] | 发生（%） | 严重程度[M（P25，P75），分] | 发生（%） | 严重程度[M（P25，P75），分] |
|---|
| S1 | 难以集中注意力 | 98（37.7） | 0（0，1） | 169（65.0） | 1（0，2） | 197（75.8） | 1（1，2） |
| S2 | 疼痛 | 165（63.5） | 1（0，1） | 190（73.1） | 1（0，2） | 170（65.4） | 1（0，2） |
| S3 | 乏力 | 158（60.8） | 1（0，1） | 237（91.2） | 2（1，2） | 242（93.1） | 2（1，2） |
| S4 | 咳嗽 | 28（10.8） | 0（0，0） | 37（14.2） | 0（0，0） | 31（11.9） | 0（0，0） |
| S5 | 精神紧张 | 179（68.8） | 1（0，2） | 148（56.9） | 1（0，1） | 91（35.0） | 0（0，1） |
| S6 | 口干 | 132（50.8） | 1（0，1） | 185（71.2） | 1（0，2） | 187（71.9） | 1（0，2） |
| S7 | 恶心 | 50（19.2） | 0（0，0） | 184（70.8） | 1（0，2） | 151（58.1） | 1（0，1） |
| S8 | 昏昏欲睡 | 78（30.0） | 0（0，1） | 91（35.0） | 0（0，1） | 97（37.3） | 0（0，1） |
| S9 | 手脚感到麻木或刺痛 | 109（41.9） | 0（0，1） | 129（49.6） | 0（0，1） | 142（54.6） | 1（0，2） |
| S10 | 睡眠不好 | 185（71.2） | 1（0，2） | 182（70.0） | 1（0，2） | 175（67.3） | 1（0，2） |
| S11 | 感觉身体肿胀 | 68（26.2） | 0（0，1） | 103（39.6） | 0（0，1） | 72（27.7） | 0（0，1） |
| S12 | 排尿有困难 | 2（0.8） | 0（0，0） | 8（3.1） | 0（0，0） | 4（1.5） | 0（0，0） |
| S13 | 呕吐 | 13（5.0） | 0（0，0） | 107（41.2） | 0（0，1） | 105（40.4） | 0（0，0） |
| S14 | 呼吸困难 | 28（10.8） | 0（0，0） | 41（15.8） | 0（0，0） | 29（11.2） | 0（0，0） |
| S15 | 腹泻 | 10（3.8） | 0（0，0） | 42（16.2） | 0（0，0） | 53（20.4） | 0（0，0） |
| S16 | 感到悲伤 | 172（66.2） | 1（0，1） | 166（63.8） | 1（0，1） | 150（57.7） | 1（0，1） |
| S17 | 出汗 | 141（54.2） | 1（0，2） | 172（66.2） | 1（0，2） | 159（61.2） | 1（0，2） |
| S18 | 焦虑不安 | 169（65.0） | 1（0，2） | 171（65.8） | 1（0，1） | 154（59.2） | 1（0，1） |
| S19 | 对性生活失去兴趣 | 92（35.4） | 0（0，2） | 85（32.7） | 0（0，1） | 99（38.1） | 0（0，2） |
| S20 | 皮肤瘙痒 | 47（18.1） | 0（0，0） | 56（21.5） | 0（0，0） | 61（23.5） | 0（0，0） |
| S21 | 没有食欲 | 61（23.5） | 0（0，0） | 172（66.2） | 1（0，2） | 162（62.3） | 1（0，2） |
| S22 | 眩晕 | 61（23.5） | 0（0，0） | 101（38.8） | 0（0，1） | 109（41.9） | 0（0，1） |
| S23 | 吞咽困难 | 6（2.3） | 0（0，0） | 11（4.2） | 0（0，0） | 9（3.5） | 0（0，0） |
| S24 | 急躁易怒 | 122（46.9） | 0（0，1） | 127（48.8） | 0（0，1） | 113（43.5） | 0（0，1） |
| S25 | 口腔溃疡 | 10（3.8） | 0（0，0） | 85（32.7） | 0（0，1） | 67（25.8） | 0（0，1） |
| S26 | 进食口味改变 | 38（14.6） | 0（0，0） | 163（62.7） | 1（0，2） | 199（76.5） | 1（1，2） |
| S27 | 体重下降 | 55（21.2） | 0（0，0） | 79（30.4） | 0（0，1） | 63（24.2） | 0（0，0） |
| S28 | 脱发 | 38（14.6） | 0（0，0） | 250（96.2） | 2（2，3） | 243（93.5） | 2（2，3） |
| S29 | 便秘 | 54（20.8） | 0（0，0） | 97（37.3） | 0（0，1） | 74（28.5） | 0（0，1） |
| S30 | 手臂或腿部肿胀 | 73（28.1） | 0（0，1） | 97（37.3） | 0（0，1） | 67（25.8） | 0（0，1） |
| S31 | 感到看起来不像自己 | 140（53.8） | 1（0，2） | 194（74.6） | 0（0，2） | 206（79.2） | 2（1，2） |
| S32 | 皮肤改变 | 7（2.7） | 0（0，0） | 146（56.2） | 1（0，1） | 191（73.5） | 1（0，2） |
), ArticleFig(id=1322530609319231941, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=CN, label=表2, caption=
乳腺癌术后化疗病人各时期的症状发生率及严重程度（n=260）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 代号 | 症状 | 化疗前 | 化疗中 | 化疗后 |
|---|
| 发生（%） | 严重程度[M（P25，P75），分] | 发生（%） | 严重程度[M（P25，P75），分] | 发生（%） | 严重程度[M（P25，P75），分] |
|---|
| S1 | 难以集中注意力 | 98（37.7） | 0（0，1） | 169（65.0） | 1（0，2） | 197（75.8） | 1（1，2） |
| S2 | 疼痛 | 165（63.5） | 1（0，1） | 190（73.1） | 1（0，2） | 170（65.4） | 1（0，2） |
| S3 | 乏力 | 158（60.8） | 1（0，1） | 237（91.2） | 2（1，2） | 242（93.1） | 2（1，2） |
| S4 | 咳嗽 | 28（10.8） | 0（0，0） | 37（14.2） | 0（0，0） | 31（11.9） | 0（0，0） |
| S5 | 精神紧张 | 179（68.8） | 1（0，2） | 148（56.9） | 1（0，1） | 91（35.0） | 0（0，1） |
| S6 | 口干 | 132（50.8） | 1（0，1） | 185（71.2） | 1（0，2） | 187（71.9） | 1（0，2） |
| S7 | 恶心 | 50（19.2） | 0（0，0） | 184（70.8） | 1（0，2） | 151（58.1） | 1（0，1） |
| S8 | 昏昏欲睡 | 78（30.0） | 0（0，1） | 91（35.0） | 0（0，1） | 97（37.3） | 0（0，1） |
| S9 | 手脚感到麻木或刺痛 | 109（41.9） | 0（0，1） | 129（49.6） | 0（0，1） | 142（54.6） | 1（0，2） |
| S10 | 睡眠不好 | 185（71.2） | 1（0，2） | 182（70.0） | 1（0，2） | 175（67.3） | 1（0，2） |
| S11 | 感觉身体肿胀 | 68（26.2） | 0（0，1） | 103（39.6） | 0（0，1） | 72（27.7） | 0（0，1） |
| S12 | 排尿有困难 | 2（0.8） | 0（0，0） | 8（3.1） | 0（0，0） | 4（1.5） | 0（0，0） |
| S13 | 呕吐 | 13（5.0） | 0（0，0） | 107（41.2） | 0（0，1） | 105（40.4） | 0（0，0） |
| S14 | 呼吸困难 | 28（10.8） | 0（0，0） | 41（15.8） | 0（0，0） | 29（11.2） | 0（0，0） |
| S15 | 腹泻 | 10（3.8） | 0（0，0） | 42（16.2） | 0（0，0） | 53（20.4） | 0（0，0） |
| S16 | 感到悲伤 | 172（66.2） | 1（0，1） | 166（63.8） | 1（0，1） | 150（57.7） | 1（0，1） |
| S17 | 出汗 | 141（54.2） | 1（0，2） | 172（66.2） | 1（0，2） | 159（61.2） | 1（0，2） |
| S18 | 焦虑不安 | 169（65.0） | 1（0，2） | 171（65.8） | 1（0，1） | 154（59.2） | 1（0，1） |
| S19 | 对性生活失去兴趣 | 92（35.4） | 0（0，2） | 85（32.7） | 0（0，1） | 99（38.1） | 0（0，2） |
| S20 | 皮肤瘙痒 | 47（18.1） | 0（0，0） | 56（21.5） | 0（0，0） | 61（23.5） | 0（0，0） |
| S21 | 没有食欲 | 61（23.5） | 0（0，0） | 172（66.2） | 1（0，2） | 162（62.3） | 1（0，2） |
| S22 | 眩晕 | 61（23.5） | 0（0，0） | 101（38.8） | 0（0，1） | 109（41.9） | 0（0，1） |
| S23 | 吞咽困难 | 6（2.3） | 0（0，0） | 11（4.2） | 0（0，0） | 9（3.5） | 0（0，0） |
| S24 | 急躁易怒 | 122（46.9） | 0（0，1） | 127（48.8） | 0（0，1） | 113（43.5） | 0（0，1） |
| S25 | 口腔溃疡 | 10（3.8） | 0（0，0） | 85（32.7） | 0（0，1） | 67（25.8） | 0（0，1） |
| S26 | 进食口味改变 | 38（14.6） | 0（0，0） | 163（62.7） | 1（0，2） | 199（76.5） | 1（1，2） |
| S27 | 体重下降 | 55（21.2） | 0（0，0） | 79（30.4） | 0（0，1） | 63（24.2） | 0（0，0） |
| S28 | 脱发 | 38（14.6） | 0（0，0） | 250（96.2） | 2（2，3） | 243（93.5） | 2（2，3） |
| S29 | 便秘 | 54（20.8） | 0（0，0） | 97（37.3） | 0（0，1） | 74（28.5） | 0（0，1） |
| S30 | 手臂或腿部肿胀 | 73（28.1） | 0（0，1） | 97（37.3） | 0（0，1） | 67（25.8） | 0（0，1） |
| S31 | 感到看起来不像自己 | 140（53.8） | 1（0，2） | 194（74.6） | 0（0，2） | 206（79.2） | 2（1，2） |
| S32 | 皮肤改变 | 7（2.7） | 0（0，0） | 146（56.2） | 1（0，1） | 191（73.5） | 1（0，2） |
), ArticleFig(id=1322530609411506630, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=EN, label=Table 3, caption=
Symptom composition and reliability coefficients of symptom clusters at different periods
, figureFileSmall=null, figureFileBig=null, tableContent=
| 症状群 | 化疗前 | 化疗中 | 化疗后 |
|---|
| 症状构成 | 信度系数 | 症状构成 | 信度系数 | 症状构成 | 信度系数 |
|---|
| 精神心理症状群 | 感到悲伤、急躁易怒、焦虑不安、精神紧张 | 0.742 | 感到悲伤、急躁易怒、焦虑不安、精神紧张 | 0.730 | 感到悲伤、急躁易怒、焦虑不安、精神紧张 | 0.760 |
| 疾病行为症状群 | 乏力、难以集中注意力、疼痛、手脚感到麻木或刺痛 | 0.627 | 乏力、难以集中注意力、睡眠不好、出汗 | 0.619 | 乏力、难以集中注意力、睡眠不好、手脚感到麻木或刺痛、出汗、口干 | 0.750 |
| 消化道症状群 | 恶心、呕吐 | 0.686 | 恶心、呕吐、没有食欲、进食口味改变 | 0.808 | 恶心、呕吐、没有食欲 | 0.720 |
| 睡眠相关症状群 | 睡眠不好、出汗、口干 | 0.485 | | | | |
| 食欲相关症状群 | 没有食欲、进食口味改变 | 0.448 | | | | |
| 身体意象症状群 | 皮肤改变、感到看起来不像自己、脱发 | 0.348 | 皮肤改变、感到看起来不像自己、脱发 | 0.550 | 皮肤改变、感到看起来不像自己、脱发、进食口味改变 | 0.791 |
| 神经相关症状群 | | | 口干、手脚感到麻木或刺痛 | 0.313 | | |
), ArticleFig(id=1322530609487004103, tenantId=1146029695717560320, journalId=1220038315760373764, articleId=1322168781674238049, language=CN, label=表3, caption=
不同时期症状群的症状构成及信度系数
, figureFileSmall=null, figureFileBig=null, tableContent=
| 症状群 | 化疗前 | 化疗中 | 化疗后 |
|---|
| 症状构成 | 信度系数 | 症状构成 | 信度系数 | 症状构成 | 信度系数 |
|---|
| 精神心理症状群 | 感到悲伤、急躁易怒、焦虑不安、精神紧张 | 0.742 | 感到悲伤、急躁易怒、焦虑不安、精神紧张 | 0.730 | 感到悲伤、急躁易怒、焦虑不安、精神紧张 | 0.760 |
| 疾病行为症状群 | 乏力、难以集中注意力、疼痛、手脚感到麻木或刺痛 | 0.627 | 乏力、难以集中注意力、睡眠不好、出汗 | 0.619 | 乏力、难以集中注意力、睡眠不好、手脚感到麻木或刺痛、出汗、口干 | 0.750 |
| 消化道症状群 | 恶心、呕吐 | 0.686 | 恶心、呕吐、没有食欲、进食口味改变 | 0.808 | 恶心、呕吐、没有食欲 | 0.720 |
| 睡眠相关症状群 | 睡眠不好、出汗、口干 | 0.485 | | | | |
| 食欲相关症状群 | 没有食欲、进食口味改变 | 0.448 | | | | |
| 身体意象症状群 | 皮肤改变、感到看起来不像自己、脱发 | 0.348 | 皮肤改变、感到看起来不像自己、脱发 | 0.550 | 皮肤改变、感到看起来不像自己、脱发、进食口味改变 | 0.791 |
| 神经相关症状群 | | | 口干、手脚感到麻木或刺痛 | 0.313 | | |
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