In recent years, significant progress has been made in the exploration of sandstone type uranium deposits in the Subash area of the Turpan-Hami basin. Exploration shows that heterogeneity of sand bodies is one of the key factors controlling uranium mineralization. This article systematically analyzes the thickness, sand content, sedimentary facies, aquiclude numbers, ore bearing sandstone grain size, and organic matter content of the Xishanyao formation in the Subash area, identifies the spatial variation characteristics of sand heterogeneity, and explores its relationship with uranium mineralization. The research results show that the thickness of sand bodies in distributary channels is relatively large, with good connectivity and strong homogeneity. The heterogeneity is strong at the bay between the distributaries, with well-developed mudstone barriers and thin sand bodies. The variation of spatial heterogeneity in sand bodies causes the changes in the direction of oxygen and uranium water transport, resulting in a decrease in fluid transport velocity, leading to uranium unloading and precipitation for the mineralization. In the Subashi area, the favorable condition for uranium mineralization is that the thickness of the sand body is 19-54m, the sand content is 60 % -80 %, the number of aquiclude is 3-5, and the lithology is fine sandstone at the transition between the underwater distributary channel and the bay with high organic matter content.