Compared with the traditional reinforced concrete and profiled double-skin composite wall (PDSCW), concrete-infilled double steel corrugated-plate wall (CDSCW) has better axial compressive capacity, lateral flexural stiffness, impact resistance and seismic performance, which has broad application prospect in ship and military field. In this paper, two types of CDSCW specimens were designed and produced. Firstly, the damage modes and dynamic responses of the two specimens were analyzed and compared through near-field explosion test. Secondly, the finite element model of CDSCW was established by using ANSYS/LS-DYNA software. The damage mechanism and explosion response of CDSCW and PDSCW under near-field explosion were studied, and the results were compared with the test results. Finally, effects of concrete thickness, steel plate thickness and charge quantity on the anti-blast performance of corrugated double steel plate composite wall board were analyzed. The results show that, compared with PDSCW, CDSCW with the same concrete and component size (length and width) have greater flexural rigidity, energy dissipation capacity, and better knock resistance performance under near field explosion. Increasing the corrugated depth can effectively improve the anti-blast performance of CDSCW, which provides reference for the design of anti-blast component and related engineering research.