Home Journals Articles Updates About
CN
image
收藏切换
Dual-Ions Substituted Hydroxyapatite Materials and Their Application in Hard Tissue Engineering
收藏切换
Zhenyu ZHONG1, 2, 3, Jun XU1, 2, 3, Zeyu SUN1, 2, 3, Yibo FAN1, 2, 3, Yingying DU1, 2, 3, Shengmin ZHANG1, 2, 3
Journal of the Chinese Ceramic Society | 2023, 51(10) : 2566 - 2578
Less
收藏切换
Journal of the Chinese Ceramic Society | 2023, 51(10): 2566-2578
• Review •
Dual-Ions Substituted Hydroxyapatite Materials and Their Application in Hard Tissue Engineering
Full
Zhenyu ZHONG1, 2, 3, Jun XU1, 2, 3, Zeyu SUN1, 2, 3, Yibo FAN1, 2, 3, Yingying DU1, 2, 3, Shengmin ZHANG1, 2, 3
Affiliations
  • 1.Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, China
  • 2.Institute of Regulatory Science for Medical Devices, Huazhong University of Science and Technology, Wuhan 430074, China
  • 3.NMPA Research Base of Regulatory Science for Medical Devices, Wuhan 430074, China

    • ZHONG Zhenyu (1991-), male, Doctoral candidate. E-mail:

About Author:

ZHONG Zhenyu (1991-), male, Doctoral candidate. E-mail:

Published: 2023-08-07 doi: 10.14062/j.issn.0454-5648.20230172
Outline
收藏切换

Hydroxyapatite (HA) is the main inorganic constituent of human hard tissue. It can effectively accelerate the repair process of hard tissue defects due to its high bioactivity and biocompatibility. Ion doping is an effective approach to enhance the bioactivity of HA materials. On this basis, dual-ion substitution can make HA materials have a higher simulation to nature bone in composition and some functional features (i.e., antitumor ability, antibacterial activity, pro-angiogenetic capacity, immunoregulatory and medical imaging capability). Dual-ion substitution greatly extends the applications of HA materials in bone tissue engineering. This review summarized the synthesis methods and their principles of dual-ion substituted HA (DIHA) materials, represented the applications of DIHA materials in hard tissue engineering, and finally proposed the future development direction of DIHA materials.

dual-ion substitution  /  hydroxyapatite  /  hard tissue engineering  /  trace element
钟振宇, 徐军, 孙泽宇, 范奕波, 杜莹莹, 张胜民. 双离子掺杂羟基磷灰石材料及其在硬组织工程中的应用. 硅酸盐学报, 2023 , 51 (10) : 2566 -2578 . DOI: 10.14062/j.issn.0454-5648.20230172
Zhenyu ZHONG, Jun XU, Zeyu SUN, Yibo FAN, Yingying DU, Shengmin ZHANG. Dual-Ions Substituted Hydroxyapatite Materials and Their Application in Hard Tissue Engineering[J]. Journal of the Chinese Ceramic Society, 2023 , 51 (10) : 2566 -2578 . DOI: 10.14062/j.issn.0454-5648.20230172
Appendix
Less
Year 2023 volume 51 Issue 10
38
5
Cite this Article
BibTeX
Article Info
doi: 10.14062/j.issn.0454-5648.20230172
  • Receive Date：2023-03-20
  • Online Date：2026-10-19
  • Published：2023-08-07
Article Data
Affiliations
History
  • Received：2023-03-20
  • Revised：2023-05-14
Funding
Affiliations
    1.Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, China
    2.Institute of Regulatory Science for Medical Devices, Huazhong University of Science and Technology, Wuhan 430074, China
    3.NMPA Research Base of Regulatory Science for Medical Devices, Wuhan 430074, China

Corresponding:

ZHANG Shengmin (1962-), male, Ph.D., Professor; E-mail:
DU Yingying (1989-), female, Ph.D., Associate Professor.
References
Share
https://castjournals.cast.org.cn/joweb/gsyxb/EN/10.14062/j.issn.0454-5648.20230172
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House