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Preparation and Drug Loading Properties of Montmorillonite Microspheres
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Jing ZHAI1, 2, 3, Juan LIAO5, Ying CHEN1, 2, 3, Aidong TANG1, 2, 3, 4, Huaming YANG1, 2, 3, 5
Journal of the Chinese Ceramic Society | 2022, 50(10) : 2746 - 2753
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Journal of the Chinese Ceramic Society | 2022, 50(10): 2746-2753
• Research Articles •
Preparation and Drug Loading Properties of Montmorillonite Microspheres
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Jing ZHAI1, 2, 3, Juan LIAO5, Ying CHEN1, 2, 3, Aidong TANG1, 2, 3, 4, Huaming YANG1, 2, 3, 5
Affiliations
  • 1.Engineering Research Center of Nano-Geomaterials of Ministry of Education, China University of Geosciences, Wuhan 430074, China
  • 2.Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China
  • 3.Key Laboratory of Functional Geomaterials in China Nonmetallic Minerals Industry, China University of Geosciences, Wuhan 430074, China
  • 4.College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
  • 5.Hunan Key Laboratory for Mineral Materials and Application, School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China

    • ZHAI Jing (1997-), female, Master candidate. E-mail:

About Author:

ZHAI Jing (1997-), female, Master candidate. E-mail:

Published: 2022-10-20 doi: 10.14062/j.issn.0454-5648.20220086
Outline
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Aiming at the challenge of how oral drug delivery systems protect drug molecules from environmental influences in human body, a pH value-sensitive sodium alginate-montmorillonite composite microsphere (MMT/SA) was synthesized by an emulsification gel method, which was used to load anticancer drug doxorubicin hydrochloride (DOX), and overcome the biochemical barrier of gastrointestinal tract while protecting drug molecules. The effect of raw material (MMT pretreatment and content) on the morphology of microspheres was investigated, and the size of microspheres with a uniform distribution was controlled to be 20 μm. The drug loading rate of DOX/MMT/SA is 14.7%, indicating different drug release effects in simulated gastric juice and artificial intestinal juice. The cumulative release rate of DOX/MMT/SA in simulated gastric juice (i.e., 31.7%) is greater than that in artificial gastric juice (i.e., 15.8%), and it has a killing effect on the cancer cells.

montmorillonite  /  oral delivery system  /  chemotherapy  /  pH value sensitivity
翟婧, 廖娟, 陈莹, 唐爱东, 杨华明. 蒙脱石微球的可控制备及其载药性能. 硅酸盐学报, 2022 , 50 (10) : 2746 -2753 . DOI: 10.14062/j.issn.0454-5648.20220086
Jing ZHAI, Juan LIAO, Ying CHEN, Aidong TANG, Huaming YANG. Preparation and Drug Loading Properties of Montmorillonite Microspheres[J]. Journal of the Chinese Ceramic Society, 2022 , 50 (10) : 2746 -2753 . DOI: 10.14062/j.issn.0454-5648.20220086
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Year 2022 volume 50 Issue 10
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Article Info
doi: 10.14062/j.issn.0454-5648.20220086
  • Receive Date：2022-01-26
  • Online Date：2026-10-20
  • Published：2022-10-20
Article Data
Affiliations
History
  • Received：2022-01-26
  • Revised：2022-03-24
Funding
Affiliations
    1.Engineering Research Center of Nano-Geomaterials of Ministry of Education, China University of Geosciences, Wuhan 430074, China
    2.Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China
    3.Key Laboratory of Functional Geomaterials in China Nonmetallic Minerals Industry, China University of Geosciences, Wuhan 430074, China
    4.College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
    5.Hunan Key Laboratory for Mineral Materials and Application, School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China

Corresponding:

CHEN Ying (1994-), female, Ph.D., Associate Professor. E-mail:
TANG Aidong (1968-), female, Ph. D., Professor;
YANG Huaming (1968-), male, Ph. D., Professor.
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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