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Osteogenic Activity of Mg-Containing Mesoporous Bioactive Glass/Hardystonite Composite Scaffold
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Zhen MA1, 2, Wei SUN2, Dandan YE1, 2, Xiaobing ZHAO1, Guocheng WANG2
Journal of the Chinese Ceramic Society | 2022, 50(7) : 1964 - 1971
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Journal of the Chinese Ceramic Society | 2022, 50(7): 1964-1971
• Research Articles •
Osteogenic Activity of Mg-Containing Mesoporous Bioactive Glass/Hardystonite Composite Scaffold
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Zhen MA1, 2, Wei SUN2, Dandan YE1, 2, Xiaobing ZHAO1, Guocheng WANG2
Affiliations
  • 1.School of Materials Science and Engineering, Changzhou University, Changzhou 213164, Jiangsu, China
  • 2.Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China

    • MA Zhen (1995-), male, Master candidate. E-mail:

About Author:

MA Zhen (1995-), male, Master candidate. E-mail:

Published: 2022-07-20 doi: 10.14062/j.issn.0454-5648.20210888
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The osteogenic activity and mechanical properties of the bone repair scaffold are important for its clinical application. Mg-M/HT porous composite scaffold was prepared with hardystonite (Ca2ZnSi2O7, HT) with good mechanical properties as a matrix and Mg-doped biodegradable mesoporous bioactive glass (MBG) as a coating. The effect of Mg doping on the microstructure and osteogenic activity of the M/HT composite scaffold was investigated. The microstructures of the composite scaffolds were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR). The osteogenic activity of the scaffolds was investigated with human bone marrow mesenchymal stem cells (hBMSCs). The results show that Mg doping can reduce the mesoporous order of MBG to a certain extent, but Mg-M/HT composite scaffold still has a uniform and ordered pore structure. Compared with M/HT scaffold, Mg-M/HT scaffold has higher intracellular focal adhesion proteins and integrins, as well as alkaline phosphatase, calcium nodules and osteocalcin expression, indicating that Mg doping can promote the osteoblast activity of M/HT scaffold. Mg-M/HT scaffold has a potential application in the field of bone tissue repair.

bone repair  /  mesoporous bioactive glass  /  hardystonite  /  magnesium  /  osteogenesis
马振, 孙伟, 叶丹丹, 赵晓兵, 王国成. 含镁介孔生物活性玻璃/锌黄长石复合支架的成骨活性. 硅酸盐学报, 2022 , 50 (7) : 1964 -1971 . DOI: 10.14062/j.issn.0454-5648.20210888
Zhen MA, Wei SUN, Dandan YE, Xiaobing ZHAO, Guocheng WANG. Osteogenic Activity of Mg-Containing Mesoporous Bioactive Glass/Hardystonite Composite Scaffold[J]. Journal of the Chinese Ceramic Society, 2022 , 50 (7) : 1964 -1971 . DOI: 10.14062/j.issn.0454-5648.20210888
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Year 2022 volume 50 Issue 7
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Article Info
doi: 10.14062/j.issn.0454-5648.20210888
  • Receive Date：2021-10-15
  • Online Date：2026-10-20
  • Published：2022-07-20
Article Data
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History
  • Received：2021-10-15
  • Revised：2021-12-06
Funding
Affiliations
    1.School of Materials Science and Engineering, Changzhou University, Changzhou 213164, Jiangsu, China
    2.Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China

Corresponding:

ZHAO Xiaobing (1975-), male, Ph. D., Professor. E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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