In order to analyze the trend and significance of the influence of different factors on the seismic performance of flexible connection autoclaved areated concrete(AAC) masonry filled wall steel frame structures, the feasibility of the modeling method and parameters selection was verified based on the results of pseudo-static tests, nine orthogonal finite element models were established by ABAQUS, and variable parameter analysis was carried out on axial compression ratio, reserved seam width, spring stiffness and height span ratio of models. The results show that the effects of reserved joint width, stiffness of energy-consuming materials, height span ratio and axial compression ratio on seismic performance of the structure decrease successively. On the whole, it is beneficial to increase the reserved joint width, reduce the stiffness of energy-consuming materials, high span ratio and axial compression ratio to improve the seismic performance of the structure. In actual application, the recommended value for the joint width between flexible connection AAC wall and frames is around 40 mm, and the stiffness of the filler between reserved joints is between 100~500 N/mm.