The construction of underground utility tunnels has developed rapidly, resulting in a large number of interchange utility tunnels, and the interchange nodes of the these tunnels are mostly cast-in-place as a whole. Due to the significant difference in lateral resisting stiffness in two orthogonal directions of the interchange utility tunnel, and the soil deformation is closely related to the buried depth of utility tunnel, the seismic response mechanism of the interchange utility tunnel is complex. In this paper, a response displacement method for the transverse seismic analysis of underground interchange utility tunnel is proposed. Taking a cross interchange cast-in-place utility tunnel as the research project, the load-structure model of the cross interchange utility tunnel is established via the response displacement method. The maximum relative deformation and its occurrence time between the layers of the interchange utility tunnel are studied, and the method in this paper is verified by the time history analysis method. Results indicate that for the underground interchange utility tunnel, the maximum relative deformation between the layers of interchange node does not occur simutaneously. Considering only the maximum relative deformation of the top slab and bottom slab of the interchange node may not be the most unfavorable condition for seismic analysis of the structure. It is necessary to calculate the maximum relative deformation between the layers of the interchange node to determine the most unfavorable condition of the overall structure. The method in this paper can accurately calculate the internal force and deformation response of underground cross interchange utility tunnel under seismic action, which is of reference value for the transverse seismic design of the underground interchange utility tunnel.