The demountable reinforced concrete column-steel beam (RCS) combined frame consists of reinforced concrete columns, steel beams and demountable connectors. The beam-column joints are connected by bolted shear-resistant connectors, which can realize the disassembly of components for recycling and ensure the effective transfer of forces. However, the seismic performance of demountable RCS frame structure is still unclear, and there is an urgent need to conduct out research on the seismic performance of demountable RCS frame structure. To this end, for the proposed static test of non-demountable conventional RCS frame structure carried out by the team in the early stage, this paper adopts the finite element software ABAQUS to establish a finite element model, and compares the finite element calculation results with the test results through the damage modes, hysteresis curves, skeleton curves, and the cumulative energy dissipation, etc., to effectively verify the accuracy of the numerical simulation. With the help of the same finite element analysis method, a finite element model of the RCS frame with the new demountable connection was established, and the seismic performance of the RCS frame specimens under different node connections was studied in depth, including the force transfer paths, stress maps, hysteresis curves, skeleton curves, stiffness degradation, ductility, and energy dissipation, etc., and the feasibility of realizing the demountability of the frame structure is also analyzed. The results show that: the new demountable joints connection can control the plastic hinge in the region of the distal beam section, effectively protect the joints core area, and improve the ultimate load carrying capacity and stiffness. The hysteresis curve is fuller, slowing down the degradation rate of the load carrying capacity and stiffness, and greatly improving the frame's energy consumption capacity. The specimens with the new demountable joints connection can effectively ensure the continuity of the force transmission path, and its seismic performance indexes are significantly better than the traditional RCS frame structure. The research results and conclusions of this paper can provide a powerful design reference and data support for the seismic design of demountable RCS frame structures.