Latest ArticlesV2O5 flower-like structures assembled by thin nanosheets were in-situ growth on ceramic tubes by hydrothermal process. The structural characterization indicates that V2O5 flower-like structures is orthogonal diamond phase, which entirely covered on the surface of ceramic tubes. TMA sensing measured results revealed that the sensor based on V2O5 flower-like structures exhibited fast reversible and response, good selectivity to TMA and good stability at 200 ℃. The good sensing performance may be ascribed to flower-like structures and directly growth sensing film on the ceramic tube without structure damage. Our works give a simple in-situ growth flower-like structures route on sensing device, which exhibits potential application for detecting trace amounts of TMA gas.
To develop a novel food preservation technology for efficiently enhance bactericidal activity in a long term, hollow mesoporous silica spheres (HMSS) with regular nanostructures were applied to encapsulate natural organic antimicrobial agents. The chemical structures, morphologies and thermal stabilities of linalool, HMSS and linalool-functionalized hollow mesoporous silica spheres (L-HMSS) nanoparticles were evaluated by polarimeter, field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), fourier transform infrared (FT-IR), thermal gravimetric analyzer (TGA), nitrogen adsorption-desorption, zeta potential and small angle X-ray diffraction (SXRD). The results show that the linalool was successfully introduced into the cavities of HMSS, and the inorganic host exhibited a high loading capacity of about 1500 mg/g. In addition, after 48 h of incubation, the minimum bactericidal concentrations (MBC) of L-HMSS against Escherichia coli (E. coli), Salmonella enterica (S. enterica) and Staphylococcus aureus (S. aureus), Listeria monocytogenes (L. monocytogenes) were decreased to be 4 (< 5) mg/mL and 8 (< 10) mg/mL, respectively. These results revealed linaloolfunctionalized hollow mesoporous spheres could efficiently improve the bactericidal activities of the organic component. Furthermore, SEM images clearly showed that L-HMSS indeed had an extremely inhibitory effect against gram-negative (E. coli) and gram-positive (S. aureus) by breaking the structure of the cell membrane. This research is of great significance in the application of linalool in nano-delivery system as well as food industry.
Flexible trimethylamine sensor has been realized based on In2O3 nanofibers via electrospinning and a deposition technique. The web-like In2O3 nanofibers with high length-to-diameter ratios are benefit for gas adsorption and desorption. High trimethylamine sensing properties are observed. The sensors can detect trimethylamine gas down to 1 ppm at 80 ℃ with the response up to 3.8. Additionally, rapid response (6 s) and recovery (10 s) behavior can also be obtained. Good reliability and flexibility are observed in 100 bending/extending cycles. Our results open a new route to construct flexible gas sensors in practice.
An optical fiber dual Fabry-Pérot interferometric carbon monoxide gas sensor based on PANI/Co3O4/GO (PCG) sensing membrane coated on the end face of the optical fiber is proposed and fabricated. One end face of photonic crystal fiber (PCF) without cut-off wavelength is fused with a single-mode fiber (SMF), and the other end face of the PCF is coated with PCG sensing membrane. The collapsed layer formed during the air hole fusion of PCF is used as the first reflector, the interface between PCF and sensing membrane is used as the second reflector, and the interface between the sensing membrane and the air is used as the third reflector, thus the dual Fabry-Pérot structure sensor is formed. The results show that the sensor has excellent sensitivity and selectivity to carbon monoxide. With the increasing concentration of carbon monoxide gas in the range of 0-60 ppm, the intensity of interference spectrum decreases. The sensitivity of the sensor is 0.3473 dB m/ppm, and its linearity is good. The response time and recovery time are 68 s and 106 s, respectively. The sensor has the advantages of the compact size, low cost, high sensitivity, strong selectivity and simple structure. It is suitable for the sensing detection of low concentration carbon monoxide gas.
Ordered mesoporous carbon (OMCs) FDU-15 was synthesized through an EISA (Evaporation-Induced Self-Assembly) method, and the oxidized OMCs (FDU-15-COOH) were obtained by subsequent oxidation treatments in liquid phase to introduce functional groups. The samples were characterized by XRD, TEM, FT-IR and nitrogen adsorption-desorption test. The low humidity sensing performances of FDU-15 and FDU-15-COOH thin films were investigated by using a quartz crystal microbalance (QCM) transducer. The responses of FDU-15-COOH is higher than that of the pristine FDU-15 at very low humidity (< 729 ppmv) with high long-term stability, implying that FDU-15-COOH is a good candidate for low humidity QCM sensor.
Detection of trace-level hydrogen sulfide (H2S) gas is of great importance whether in industrial production or disease diagnosis. This research presents a novel H2S gas sensor based on integrated resonant dual-microcantilevers which can identify and detect trace-level H2S in real-time. The sensor consists of two integrated resonant microcantilever sensors with different functions. One cantilever sensor can identify H2S by outputting positive frequency shift signals, while the other cantilever sensor will detect H2S as a normally used cantilever sensor with negative frequency shifts. Combined the two cantilever sensors, the proposed gas sensor can distinguish H2S from a variety of common gases, and the detection limit to H2S of the sensor is as sensitive as below 1 ppb.
Great success has been witnessed in last decades, some new techniques and strategies have been widely used in drug discovery. In this roadmap, several representative techniques and strategies are highlighted to show recent advances in this filed. (A) A DOX protocol has been developed for accurate protein-ligand binding structure prediction, in which first principle method was used to rank the binding poses. Validation against crystal structures have found that DOX prediction achieved an impressive success rate of 99%, indicating significant improvement over molecular docking method. (B) Virtual target profiling is a compound-centric strategy enabling a parallel implementation of interrogating compounds against various targets in a single screen, which has been used in hit/lead identification, drug repositioning, and mechanism-of-action studies. Current and emerging methods for virtual target profiling are briefly summarized herein. (C) Research on targeted autophagy to treat diseases has received encouraging progress. However, due to the complexity of autophagy and disease, experimental and in silico methods should be performed synergistically for the entire process. This part focuses on in silico methods in autophagy research to promote their use in medicinal research. (D) Histone deacetylases (HDACs) play important roles in various biological functions through the deacetylation of lysine residues. Recent studies demonstrated that HDACs, which possess low deacetylase activities, exhibited more efficient defatty-acylase activities. Here, we review the defatty-acylase activity of HDACs and describe examples for the design of isoform selective HDAC inhibitor. (E) The FDA approval of three kinase allosteric inhibitors and some others entering clinical study has spurred considerable interests in this targeted drug discovery area. (F) Recent advances are reviewed in structure-based design of novel antiviral agents to combat drug resistance. (G) Since nitric oxide (NO) exerts anticancer activity depending on its concentration, optimal levels of NO in cancer cells is desirable. In this minireview, we briefly describe recent advances in the research of NO-based anticancer agents by our group and present some opinions on the future development of these agents. (H) The field of photoactivation strategies have been extensively developed for controlling chemical and biological processes with light. This review will summarize and provide insight into recent research advances in the understanding of photoactivatable molecules including photoactivatable caged prodrugs and photoswitchable molecules.
Photodynamic therapy (PDT) is a promising alternative approach for effective cancer treatment, which can directly destroy local tumor cells due to the generation of cytotoxic singlet oxygen and reactive oxygen species (ROS) in the tumor cells. Intriguingly, PDT-mediated cell death is also associated with anti-tumor immune response. However, immunosuppression of tumor microenvironment is able to limit the immune response induced by PDT, it is therefore necessary to combine with immunocheckpoint inhibitor and immunoadjuvant for synergistic treatment of tumors. Herein, the recent advances of PDT, immunotherapy, and photodynamic immunotherapy are reviewed.
Last two decades, with the rapid changes and development of nanotechnology and biological materials, diverse multi-functional nanomaterials emerging, which offers a novel way to treat and diagnose diseases, and therefore spawned the new biomedical technology of theranostics, which integrates the treatment and diagnosis or monitoring of diseases into one. Ag2S as a bio-nanomaterial with low biotoxicity has attracted more and more attention due to its good photoluminescence properties and fluorescence imaging of small animals in the second near-infrared region (NIR-II). Meanwhile, Ag2S has the ability to absorb near-infrared light strongly because of its local surface plasma resonance (LSPR) effect and had become a kind of photothermal converters with good photothermal conversion efficiency. More interestingly, both photothermal effect and fluorescence characteristics of Ag2S nanoparticles (NPs) are closely related to their particle sizes. However, the relationship between photothermal effect and fluorescence characteristics of Ag2S NPs and their sizes has not been reviewed so far. Herein, the synthesis methods and influencing factors of synthesize Ag2S NPs with different sizes were compared firstly, and then the photothermal effect and fluorescence characteristics of Ag2S NPs with different sizes were summarized. Finally, the possibilities and challenges of using Ag2S NPs to construct theranostic agent were discussed in the end.
Oral administration has been widely regarded as the most convenient, quick and safe approach compared to other routes of drug delivery. However, oral absorption of drugs is often limited due to rigorous environments and complex obstacles in gastrointestinal tract. Having received considerable attention, biomacromolecules have been applied for oral drug delivery to improve the bioavailability, which could be attributed to its stability and unique bioactivities, including intestinal adhesion, opening of epithelial tight junctions, inhibiting cell efflux and regulating relative protein expression. Specifically, enhancing intestinal permeability has been regarded as a promising strategy for improving bioavailability of oral drug delivery. In this review, a series of biomacromolecules and the related mechanisms of increasing intestinal permeability for enhanced oral bioavailability are comprehensively classified and elucidated. In addition, recent advances in biomacromolecules based oral delivery and related future directions are mentioned and predicted in this review article.
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