Latest ArticlesWe developed one-pot aqueous copolymerization of two dopamine prodrugs to prepare dual drugs-conjugated polydopamine nanoparticles (PDOXCBs), which integrated near infrared (NIR)-mediated photothermal effect with cocktail chemotherapy into one copolymer nanoparticle. Upon a mild NIR irradiation (808 nm, 1 W/cm2, 10 min), PDOXCBs gradually heated aqueous solution over 12.8–13.9 ℃, which accordingly enhanced in vitro dual doxorubicin (DOX) and chlorambucil (CB) drug-release with assistance of the other stimuli of pH 5.0 and 10 mmol/L D,L-dithiothreitol (DTT). The combination photothermal-cocktail chemotherapy (PTT－CCT) treatment based on PDOXCB27 plus NIR irradiation gave a highly lowered half maximal inhibitory concentration (IC50) of 2.23 μg/mL and a combination index of 0.36, displaying a superior synergistic effect between PTT and CCT in vitro.
Polymorphism is a common phenomenon in nature. Here, we report one-pot wet chemical method to synthesize two polymorphs of Au19Ag4(S-Adm)15 nanocluster protected by 1-adamantanethiol (HS-Adm), which adopt P-1 and P21/c space group respectively. The crystal structures of two polymorphs were determined by X-ray crystallography. Compared to the previously reported Au19Ag4(S-Adm)15 nanocluster adopting P21/n space group, polymorphs of Au19Ag4(S-Adm)15 with P-1 and P21/c space group show the different optical properties. Moreover, Au19Ag4(S-Adm)15 with P-1 space group exhibits good thermal stability. Meanwhile, we investigated the effect of solvent and molar ratio of metal precursors on the polymorphs. This work provides an insight to polymorphs of metal nanoclusters.
One 6-metal Zn-Nd complex [Zn2Nd4L2(OAc)10(OH)2(CH3OH)2] (1) with Schiff base ligand bis(3-methoxysalicylidene)ethylene-1,2-phenylenediamine (H2L) was constructed, and it has nanoscale rectangular structure (8×11×28 Å). Excited by ligand-centered absorption bands, 1 shows NIR emission of Nd3+ ion. Interestingly, 1 exhibits lanthanide luminescent response towards metal ions, especially to alkali metal ions (Li+, Na+ and K+) at ppm level.
Fragrances are widely used in cosmetics, apparel and detergents. However, the rapid evaporation of the aroma shortens the useful life of the aromatic product. Therefore, improving the fragrance retention time of aromatic products and prolonging the service life of aromatic products are the key scientific problems that need to be solved in current aromatic products. In this study, zwitterionic comb-like lipid polymers were synthesized to encapsulate the fragrance molecule linalool. The results showed that the zwitterionic comb lipid molecules were capable of encapsulating more linalool than linear lipid molecules. At the same time, the zwitterionic comb-like lipid molecules also limited the slow release rate of the aroma, thereby increasing the fragrance retention time of the nano-fragrance.
The demand for injectable dermal filler has undergone significant growth with the rapid development of the beauty industry. Poly(lactic acid) (PLA) as a benefit of excellent biocompatibility and long-term promotion of collagen regeneration has been favored as a commonly used filler. However, the effects of chirality and particle size of PLA on the efficacy of dermal filler have not been studied. In this study, we prepared three kinds of microspheres (MSs) consisting of poly(D-lactic acid) (PDLA MS), poly(L-lactic acid) (PLLA MS), or meso-PLA (PDLLA MS) at 5, 10 and 20 μm to reveal the different biological functions as dermal filler. Following intradermal injection into guinea pig, it was found that PLLA MS induced the slightest inflammation, and the level of pro-inflammatory cytokine IL-1β induced by PLLA MS is only 0.3 or 0.7-fold of that induced by PDLA or PDLLA MS, respectively. More importantly, PLLA MS significantly stimulated the regeneration of collagen, which was 1.4 or 1.1 times higher than those stimulated by PDLA MS or PDLLA MS, respectively. The size of PLA MSs did not affect the levels of inflammation and collagen regeneration. The results confirmed the superiority of PLLA as a dermal filler.
The 2D nanomaterials have achieved the superlubrication property whatever in solid or liquid lubrication in recent years. However, whether or not the nanosheets can stably disperse in oils and smoothly enter into the asperity of friction pairs is crucial for exerting the function of antifriction. The structure of 2D QDs is desirable for addressing these issues due to its smaller 3D size. In this study, we developed a facile preparation process for WS2 QDs with uniform 2 nm size from nanosheets via hydrothermal-assisted grinding approach. The structure of the as-obtained WS2 QDs was determined by a series of characterizations. The results showed that the as-obtained WS2 QDs exhibited the typical spectrum features of nanosized quantum dot. The results of the tribological performance in grease verified that the average friction coefficient (ACOFs) and wear volume (AWVs) were decreased by 7.89% and 63.90% relative to grease, respectively, exhibiting a preferable friction reducing and wear resistance.
Konjac tofu is a traditional Chinese food whose main ingredient is the water-soluble polysaccharide from konjac tubers-konjac glucomannan (KGM). Herein we report an interpenetrating double network polymeric film by crosslinking KGM and polyvinyl alcohol (PVA) with glutaraldehyde under acidic conditions. PVA was introduced into the hydrogel system as a hard skeleton, which not only maintained the biocompatibility of KGM, but also gave the hydrogel superior mechanical properties and solvent resistance. Implanting a colloidal array inside the above film, we obtained a new type of biomass based photonic crystal that is sensitive to a variety of physical and chemical stimulus, especially for methanol. This photonic crystal responds to methanol and methanol vapor, and has the ability to detect methanol in gasoline, which has a good application prospect.
The recent molecular iodine catalyzed [1, 2]-rearrangement of aryl amines and 3-amino-1H-indazolesfor the synthesis of 1, 2, 3-benzotriazines is highlighted.
The recent development of selective oxidation of aromatic sulfides with molecular oxygen was highlighted. The sulfoxides and sulfones could be obtained by simply switching the reaction media, i.e., bis(2-butoxyethyl)ether (BBE) or poly(ethylene glycol)dimethyl ether (PEGDME). The application of the high-boiling-point polyether as an initiator and green media can eliminate the need of large quantities of additives and volatile solvents. This strategy represents an economic and eco-friendly method that could find potential applications.
The deconstructive reorganization strategy for the synthesis of benzene-containing products from the kojic acid- and maltol-derived alkynes has been recently reported. In this strategy, kojic acid and maltol are analogous to the "Transformers", which can transform into benzofurans and benzaldehydes via annulation reactions. Under the synthetic standpoint, this deconstructive reorganization strategy features high atom economy, innate scalability and functional group tolerance. In the near future, we believe that this unique method will be widely investigated and other novel transformations of kojic acid and maltol will be discovered.
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