Latest ArticlesDensity functional theory calculations have been performed to investigate the copper-catalyzed borocyanation of 1-aryl-1,3-butadienes. The computations show that the regio- and enantioselectivity is determined by the borocupration step. The π-electron withdrawing aryl group at the C1 atom makes the C4 atom more electrophilic than the other carbon atoms, which together with the steric repulsion around the forming C—B bond, results in the experimentally observed exclusive 4,3-regioselectivity. The origins of the enantioselectivity were attributed to the steric effect and π-π stacking interaction between the butadiene moiety and the ligand.
For bone regenerative engineering, it is a promising method to form skeletal tissues differentiating from human bone morrow mesenchyme stem cells (hBMSCs). However, it is still a critical challenge to efficiently control ostogenesis and clearly reveal the influence factor. To this end, the fluorescent gold nanodots (Au NDs) with highly negative charges as osteogenic induction reagent are successfully synthesized, which display better than commercial osteogenic induction medium through the investigations of ALP activity (2.5 folds) and cytoskeleton staining (1.5 folds). Two kinds of oligopeptides with different bio-structures (cysteine, Cys and glutathione, GSH) are selected for providing surficial charges on Au NDs. It is revealed that Au-Cys with more negative charges (-51 mV) play better role than Au-GSH (-19 mV) in osteogenic differentiation, when both of them have same size (~2 nm), sphere shape and show similar cell uptake amount. To explore deeply, osteogenesis related signaling pathways are monitored, revealing that the enhancement of osteogenic differentiation was through autophagy signaling pathway triggered by Au-Cys. And the promotion of highly negative charges in osteogenic differentiation was further proved via sliver nanodots (Ag NDs, Ag-Cys and Ag-GSH) and carbon nanodots (CDs, Cys-CDs and GSH-CDs). This work indicates part of insights during hBMSCs differentiation and provides a novel strategy in osteogenic differentiation process.
Two fluoride sulfates, K2Mn3(SO4)3F2·4H2O (I) and Rb2Mn3(SO4)3F2·2H2O (Π) are obtained by water solution method. Single-crystal X-ray diffraction analysis indicated that they crystallize in space groups of Cmc21. Their structures feature a pseudo-KTP structure consisting of interconnecting [Mn3(SO4)3F2(H2O)2]∞ layers, which are further packing along the a axis with alkali metal cations balancing the charges. The structure relationships between the two compounds are discussed. Second-harmonic generation measurements manifest that I and Π have similar second-harmonic generation responses of about 0.2 and 0.25 times that of KH2PO4.
SnO2 is considered a promising anode material for sodium-ion batteries due to its high theoretical capacity and low cost. However, the poor electrical conductivity and dramatic volume variation during charge/discharge cycling is a major limitation in its practical applicability. Here we propose a simple one-pot spray pyrolysis process to construct unique pomegranate-like SnO2/rGO/Se spheres. The ideal structural configuration of these architectures was effective in alleviating the large volume variation of SnO2, besides facilitating rapid electron transfer, allowing the devised anode to exhibit superior sodium storage performances in terms of capacity (506.7 mAh/g at 30 mA/g), cycle performance (397 mAh/g after 100 cycles at 50 mA/g) and rate capability (188.9 mAh/g at an ultrahigh current density of 10 A/g). The experimental evidence confirms the practical workability of p-SnO2/rGO/Se spheres in SIBs.
A simple method to synthesize luminescent λ5-phosphanaphthalenes and zwitterionic nido-carborane fused six-membered phosphacycles was developed from the reaction of ortho-phosphinobenzoalde-hydes or ortho-phosphinocarboranylaldehydes with an electron-deficient alkyne, respectively. Similar results were obtained with the imino analogues.
Nickel- and palladium-catalyzed cross-coupling reactions have attracted wide attentions, while ligandcontrolled selectivity in these reactions are still elusive, and calculations can help obtain possible catalytic cycles to generate different products and provide insights into key factors of selectivity, which facilitates the development of new catalyst systems to control reaction selectivity. This review covers our efforts and some significant achievements from other groups on ligand-controlled reaction selectivity of coupling reactions, including introduction, computational methods, selectivity control by ligands in Ni- and Pd-catalyzed coupling reactions, as well as summary and future perspectives.
Highly efficient Co3O4/TiO2 monolithic catalysts with enhanced stability were in-situ grown on Ti mesh for CO oxidation, which could completely oxidize CO at 120 ℃. The comprehensive catalytic performance is competitive to some noble metal catalysts and conventional Co3O4 powder catalysts, which holds great potential toward industrial applications. Meanwhile, the in-situ synthesis strategy of Co3O4/TiO2 monolithic catalysts on flexible mesh substrate in this work can be extended to the development of a variety of oxide-based monolithic catalysts towards diverse catalysis applications.
The metabolic disorder of glucose in human body will cause diseases such as diabetes and hyperglycemia. Hence the determination of glucose content is very important in clinic diagnosing. In recent years, researchers have proposed various non-invasive wearable sensors for rapid and real-time glucose monitoring from human body fluids. Unlike those reviews which discussed performances, detection environments or substrates of the wearable glucose sensor, this review focuses on the sensing nanomaterials since they are the key elements of most wearable glucose sensors. The sensing nanomaterials such as carbon, metals, and conductive polymers are summarized in detail. And also the structural characteristics of different sensing nanomaterials and the corresponding wearable glucose sensors are highlighted. Finally, we prospect the future development requirements of sensing nanomaterials for wearable glucose sensors. This review would give some insights to the further development of wearable glucose sensors and the modern medical treatment.
Metal-free direct α-C(sp3)—H intramolecular cyclization of 2-alkylthiobenzoic acid in the presence of Selectfluor is described. This novel strategy provides a facile and efficient method to access important 1, 3-benzooxathiin-4-one derivatives with good functional groups tolerance and yields.
Selection of aptamers with high affinity and good specificity requires multiple rounds of alternating steps of separation and PCR amplification. Herein, we proposed a novel high-efficiency aptamers picking strategy: One-round pressure controllable selection (OPCS). OPCS integrates four types of screening superiority, high-efficiency separation, one-round selection and PCR amplification, synchronous negative selection and targets competition. The controllable screening pressure can be achieved through two approaches, balanced competition by the regulation of protein concentration, and dominant competition by introducing a predatory protein with high concentration. In OPCS process, two proteins were co-incubated with one ssDNA library, and each protein bound its favorable sequences specifically and formed protein-ssDNA complex respectively. Meanwhile, one protein could supply/suffer the picking pressure of affinity and specificity to/from another, which eliminated weakly bound or unbound sequences for each other. Two complexes could be separated and collected conveniently, and aptamers for two proteins obtained synchronously with high affinity and good specificity. This strategy not only provides a more effective way for aptamers selection, but shows great potential in other ligands or drugs selection.
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