Latest ArticlesAn efficient and facile method for C–H amination of quinoxalinones with heteroaromatic amines under metal-free conditions has been described. In the presence of hypervalent PIDA reagent, the desired products with various groups were obtained with moderate to high yields.
Extensive research has been performed on cell membrane camouflaged-based drug delivery systems in recent years. Herein, we provide an overview of the challenges in system preparation, functional design, continuous industrial production of these systems, and solution strategies for these challenges. Further, we analyze and discuss the frontier medical applications of cell membrane-camouflaged drug delivery systems in anti-inflammatory, anti-pathogenic microorganisms, and biological detoxification. This review takes a challenge-oriented perspective and seeks innovative strategies, provides a literature review of research into cell membrane-camouflaged drug delivery systems, and promotes the development of personalized clinical treatments.
A series of multi-(phenylthio)porphyrinato Ni(ò) compounds were synthesized without the participation of transition metal catalysts. All of these products were well characterized by 1H NMR, 13C NMR and HRMS. Structures of three typical compounds were further confirmed by X-ray single crystal diffraction. Remarkable red shifts were observed in UVɃvis absorption spectra of multi-(phenylthio)porphyrinato Ni(ò) compounds which meet well with the electrochemical data. DFT calculation indicates that the phenylthio groups have strong effects on the frontier orbitals of these molecules. The order of a1u-like and a2u-like orbitals mainly distributed in porphyrin moiety is often inversed in energy when multi-phenylthio groups are attached.
Supramolecular transformations of coordination cage or capsule have received much attention recently, which help elucidate this natural self-assembly behavior in biological systems. The current study describes the first supramolecular transformation of titanium–organic coordination capsule triggered by phenol (and H3PO3). The structural alterations are accompanied by the reconstruction of 5-coordinated Ti centers to 6-coordinated ones. Meanwhile, different amounts of encapsulated phenol guest molecules can be identified, dependent on the sizes of the obtained cavities. In addition, they display much better visible light absorption and air stability than the isopropanol stabilized ones.
Developing low toxicity and multifunctional theranostic nanoplatform is the key for precise cancer diagnosis and treatment. Herein, an inorganic-organic hybrid nanocomposite is designed by modifying zirconium dioxide (ZrO2) with polydopamine (PDA) followed by doping Mn2+ ions and functionalizing with Tween 20 (Tween-ZrO2@PDA-Mn2+) for multimodal imaging and chemo-photothermal combination therapy. The as-prepared nanocomposite exhibits good biocompatibility in vitro and in vivo. Specifically, it can be employed as a multifunctional platform not only for computed tomography (CT) imaging and T1-weighted magnetic resonance (MR) imaging, but also for efficient chemotherapeutic drug doxorubicin hydrochloride (DOX) loading. Importantly, because of the pronounced photothermal conversion performance and controllable DOX release ability triggered by the near-infrared (NIR) irradiation and acidic pH, the synergistic effect between photothermal therapy and chemotherapy results in an enhanced cancer treatment efficacy in vivo. Our work provides a high-performance inorganic-organic hybrid nanotheranostic platform for chemo-photothermal cancer therapy guided by CT and MR imaging.
Bimetallic nanoparticles modified hollow-structured nanoporous carbons (NPCs) have been fabricated via a convenient one-step carbonizing strategy derived from covalent organic framework. The Pd/Fe/NPCs, Pt/Fe/NPCs and Rh/Fe/NPCs were obtained and can be used as Fenton-like catalysts with good stability and reusability. The catalytic activity was evaluated by the degradation of 2, 4-dichlorophenl (2, 4-DCP). These fabricated bimetallic catalysts exhibited much higher catalytic activity than Fe/NPCs at room temperature. The enhancement of catalytic ability was benefited from synergetic catalytic effect of bimetallic nanoparticles and accelerated mass transfer of hollow structure. Additionally, the enhanced catalytic mechanism of bimetallic catalysts was studied in detail and the reasonable reaction pathway was proposed. Besides, the bimetallic catalysts were successfully used for degradation of 2, 4-DCP in actual industrial wastewater and the removal efficiency could reach 74.3% within 120 min, which demonstrated the promising potential application of bimetallic catalysts in the removal of pollutants in environment.
Gold nanovesicles (GVs) with unique plasmonic property and large cavity hold great potential as a stimuli-responsive nanocarrier to deliver drugs for efficient tumor chemotherapy and other therapies synergistically. Herein, we developed doxorubicin-loaded gold nanovesicles (DGVs), offering infrared thermal (IRT) and photoacoustic (PA) dual-modal imaging guided mild hyperthermia-enhanced chemo-photothermal cancer synergistic therapy. The DGVs are self-assembled by gold nanoparticles modified with amphiphilic copolymer in a predetermined concentration of doxorubicin through film rehydration method. Under the influence of laser excitation, the as-prepared DGVs exhibited good photothermal effect, which triggered the structural disruption of GVs and thus, allowed the efficient release of encapsulated DOX to enhance cell uptake for fluorescence imaging and tumor chemotherapy, respectively. In addition, DGVs also showed a strong PA and IRT signals in vivo. Our study demonstrated the potential of DGVs as stimuli-responsive drug delivery systems and cancer theranostics.
In this study, Mn catalysts have been designed based on manganese oxide octahedral molecular sieve (OMS-2) supports to optimize the catalytic activity in the degradation of organic pollutants. Herein, two different synthetic strategies: Pre-incorporation vs. wet-impregnation have been employed to synthesize [PW]-OMS-2 and [PW]/OMS-2. For [PW]-OMS-2, energy dispersive X-ray spectroscopy (EDX) confirmed that dispersed granular phosphotungstic acid attached and located at the surface of OMS-2, meanwhile some W atoms have been doped into frameworks of OMS-2. However, for [PW]/OMS-2, the W atoms cannot enter the OMS-2 frameworks. A correlation has been established between the different synthetic strategies and catalytic activities. The [PW]-OMS-2 is the most highly effective and stable over than [PW]/OMS-2 and OMS-2 itself for the organic pollutants removal. This may be caused not only by the synergetic effect of [PW] and OMS-2, but also by doping W into frameworks of OMS-2. Therefore, this work provides a new environmentally-friendly and heterogeneous PMS activator and it may be put into practice to degrade organic pollutants.
Different from traditional metal-support heterogenous catalysts, inverse heterogeneous catalysts, in which the surface of metal is decorated by metal oxide, have recently attracted increasing interests owing to the unique interfacial effect and electronic structure. However, a deep insight into the effect of metal-oxide interaction on the catalytic performance still remains a great challenge. In our work, an inverse hematite/palladium (Fe2O3/Pd) hybrid nanostructure, i.e., the active Fe2O3 ultrathin oxide layers partially covering on the surface of Pd nanoparticles (NPs), exhibited superior electrocatalytic performance towards methanol oxidation reaction (MOR) as compared to the bare Pd NPs based on density functional theory calculation. The charge could transfer from Pd to Fe2O3 driven by the built-in potential at the interface of Pd and Fe2O3, which favors the downshift of d band center of Pd. With the assistance of interfacial hydroxyl OH*, the cleavage of OH and CH in CH3OH could take place much easily with lower barrier energy on Fe2O3/Pd than that on pure Pd via two electrons transferring reaction pathways. Our results highlight that the synergy of Pd and Fe2O3 at the interface could facilitate the electrochemical transformation of methanol into formaldehyde assisted with interfacial hydroxyl OH*.
Bi draws increasing attention as anode materials for lithium-ion batteries and sodium-ion batteries due to its unique layered crystal structure, which is in favor of achieving fast ionic diffusion kinetics during cycling. However, the dramatic volume expansion upon lithiation/sodiation and an insufficient theoretical capacity of Bi greatly hinder its practical application. Herein, we report the Fe2O3 nanoparticle-pinning Bi-encapsulated carbon fiber composites through the electrospinning technique. The introduction of Fe2O3 nanoparticles can prevent the growth and aggregation of Bi nanoparticles during synthetic and cycling processes, respectively. Fe2O3 with high specific capacity also contributes to the specific capacity of the composites. Consequently, the as-prepared Bi-Fe2O3/carbon fiber composite exhibits outstanding long-term stability, which delivers reversible capacities 504 and 175 mAh/g after 1000 cycles at 1 A/g for lithium-ion and sodium-ion batteries, respectively.
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