Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (5) : 2559 - 2574. DOI: 10.1016/j.apsb.2025.03.039

ORIGINAL ARTICLES

CDH17-targeting CAR-NK cells synergize with CD47 blockade for potent suppression of gastrointestinal cancers

Liuhai Zheng ^a^,^b ,
Youbing Ding ^a^,^c ,
Xiaolong Xu ^a^,^b ,
Huifang Wang ^a^,^b ,
Guangwei Shi ^d ,
Yang Li ^a ,
Yuanqiao He ^e^,^f ,
Yue Gong ^a ,
Xiaodong Zhang ^c ,
Jinxi Wei ^a ,
Zhiyu Dong ^a ,
Jiexuan Li ^a ,
Shanchao Zhao ^g^,^h^,ⁱ^,^* ,
Rui Hou ^a^,^* ,
Wei Zhang ^a^,^j^,^* ,
Jigang Wang ^a^,^j^,^k^,^l^,^m^,ⁿ^,^* ,
Zhijie Li ^a^,^*

Author information +

^aDepartment of Critical Care Medicine, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Centre for Geriatrics, Department of Nuclear Medicine, Shenzhen People's Hospital (the First Affiliated Hospital, Southern University of Science and Technology, the Second Clinical Medical College, Jinan University), Shenzhen 518020, China

^bIntegrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China

^cDepartment of Medical Imaging, the Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Guangzhou 510630, China

^dDepartment of Neurosurgery & Medical Research Center, Shunde Hospital, Southern Medical University (the First People's Hospital of Shunde Foshan), Guangzhou 510515, China

^eCenter of Laboratory Animal Science, Nanchang University, Nanchang 330031, China

^fKey Laboratory of New Drug Evaluation and Transformation of Jiangxi Province, Nanchang 330031, China

^gDepartment of Urology, the Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510900, China

^hDepartment of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China

ⁱDepartment of Urology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

^jCenter for Drug Research and Development, Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations, Guangdong Pharmaceutical University, Guangzhou 510006, China

^kState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

^lDepartment of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

^mDepartment of Traditional Chinese Medicine and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China

ⁿState Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, Kaifeng 475004, China

^* Corresponding authors.

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Received	Accepted	Published
2024-05-16	2024-12-20
Issue Date
2026-09-17

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