Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (2) : 1070 - 1083. DOI: 10.1016/j.apsb.2024.12.042

ORIGINAL ARTICLE

A novel anti-ischemic stroke candidate drug AAPB with dual effects of neuroprotection and cerebral blood flow improvement

Jianbing Wu ^a ,
Duorui Ji ^a ,
Weijie Jiao ^a^,^b ,
Jian Jia ^a^,^c ,
Jiayi Zhu ^a ,
Taijun Hang ^d ,
Xijing Chen ^e ,
Yang Ding ^f ,
Yuwen Xu ^g ,
Xinglong Chang ^h ,
Liang Li ^h ,
Qiu Liu ^h ,
Yumei Cao ^h ,
Yan Zhong ^h ,
Xia Sun ^h ,
Qingming Guo ^h ,
Tuanjie Wang ^h ,
Zhenzhong Wang ^h ,
Ya Ling ^h ,
Wei Xiao ^h^,ⁱ^,^* ,
Zhangjian Huang ^a^,^* ,
Yihua Zhang ^a^,^*

Author information +

^aState Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China

^bDepartment of Pharmacy, Henan Province Hospital of Traditional Chinese Medicine, the Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450002, China

^cNovel Technology Center of Pharmaceutical Chemistry, Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China

^dDepartment of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China

^eClinical Pharmacokinetics Laboratory, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China

^fKey Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China

^gCrystal Pharmatech Co., Ltd., Suzhou 215123, China

^hState Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China

ⁱNanjing University of Chinese Medicine, Nanjing 210023, China

^* Corresponding authors.

收起

Received	Accepted	Published
2024-09-22	2024-12-18
Issue Date
2026-09-17

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