^aState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China

^bBiomedical Translational Research Institute, Jinan University, Guangzhou 510632, China

^cState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102, China

^dSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China

^eDepartment of Pathology and Institute of Precision Medicine, Jining Medical University, Jining 272067, China

^fDepartment of Pathology, Medical School, Dalian University, Dalian 116622, China

^gDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China

^hSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China

ⁱInstitute of Biomedical Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan 250014, China

^jNational Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004 China

^kState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

^lDepartment of Colorectal Surgery, Tianjin Union Medical Center, Nankai University, Tianjin 300121, China