中医药学报

中医药通过调控多巴胺能信号通路治疗儿童抽动障碍的研究进展

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龚玉婷 , 郑攀 ^* , 陈枫

中医药学报 | 研究进展 2026,54(10): 122-126

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中医药学报 |研究进展 2026 , 54 (10) : 122 -126

中医药通过调控多巴胺能信号通路治疗儿童抽动障碍的研究进展

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龚玉婷, 郑攀^*, 陈枫

作者信息

河南中医药大学中医学院，河南　郑州　450046

通讯作者:

^* 郑攀（1977-），男，博士，教授，硕士生导师，研究方向：方剂作用机制与配伍规律。

作者简介:

龚玉婷（1999-），女，硕士研究生，研究方向：方剂作用机制与配伍规律。

Research Progress on the Treatment of Childhood Tic Disorders with Traditional Chinese Medicine by Regulating Dopaminergic Signaling Pathways

Yuting GONG, Pan ZHENG^*, Feng CHEN

Affiliations

College of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China

出版时间: 2026-10-20 doi: 10.19664/j.cnki.1002-2392.260214

文章导航

摘要

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儿童抽动障碍（TD）作为一种复杂的神经发育障碍性疾病，其核心病理环节与多巴胺能系统功能紊乱密切相关。近年来，中医药在TD防治中展现出整体调节、多靶点、多通路干预等优势。多巴胺能信号通路在TD的发生发展过程中发挥关键作用，中医药可通过调控多巴胺D1/D2受体功能、多巴胺转运体（DAT）表达、多巴胺代谢酶活性及突触可塑性等环节，改善神经递质稳态，进而减轻抽动症状。天麻钩藤饮、健脾止动汤、宁动颗粒、柴胡加龙骨牡蛎汤等方剂可能分别通过调节D1/D2受体功能平衡、影响DAT表达、调控儿茶酚-O-甲基转移酶（COMT）与单胺氧化酶B（MAO-B）等多巴胺代谢酶活性，以及改善突触相关蛋白表达和神经环路功能，从而参与多巴胺能系统稳态重建并减轻抽动症状。本文围绕中药活性成分、中药复方及中成药调控多巴胺能信号通路治疗儿童抽动障碍的作用机制进行综述，以期为中医药防治TD提供理论依据与研究思路。

关键词

儿童抽动障碍 / 中医药 / 多巴胺能信号通路 / 受体变构调控 / 神经递质稳态 / 整合治疗

Abstract

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Childhood tic disorders (TD) are complex neurodevelopmental disorders, with core pathological mechanisms closely linked to dopaminergic system dysfunction. In recent years, traditional Chinese medicine (TCM) has demonstrated advantages such as holistic regulation multi-target and multi-pathway intervention in the prevention and treatment of pediatric TD. The dopaminergic signaling pathway plays a pivotal role in the onset and progression of TD. By regulating the functions of dopamine D1/D2 receptors, the expression of dopamine transporter (DAT), the activity of dopamine-metabolizing enzymes, and synaptic plasticity, TCM can restore the homeostasis of neurotransmitters and thereby alleviate tic symptoms. Formulas such as Tianma Gouteng Decoction, Jianpi Zhidong Decoction, Ningdong Granules and Chaihu Plus Longgu Muli Decoction can participate in reconstructing the homeostasis of the dopaminergic system and relieve tics. Specifically, they act by balancing the function of D1/D2 receptors, modulating DAT expression, regulating the activity of dopamine-metabolizing enzymes such as COMT and MAO-B, as well as optimizing the expression of synaptic-related proteins and the function of neural circuits. This article reviews the mechanisms of active ingredients of Chinese medicinal herbs, TCM compound prescriptions and proprietary Chinese medicines in treating pediatric TD via regulating the dopaminergic signaling pathway, aiming to provide theoretical basis and research ideas for the prevention and treatment of TD with TCM.

Key words

Childhood tic disorder / Traditional Chinese Medicine / Dopaminergic signaling pathway / Receptor allosteric modulation / Neurotransmitter homeostasis / Integrated treatment

引用本文

龚玉婷, 郑攀, 陈枫. 中医药通过调控多巴胺能信号通路治疗儿童抽动障碍的研究进展. 中医药学报, 2026 , 54 (10) : 122 -126 . DOI: 10.19664/j.cnki.1002-2392.260214

Yuting GONG, Pan ZHENG, Feng CHEN. Research Progress on the Treatment of Childhood Tic Disorders with Traditional Chinese Medicine by Regulating Dopaminergic Signaling Pathways[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (10) : 122 -126 . DOI: 10.19664/j.cnki.1002-2392.260214

基金

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国家中医药管理局科技项目(GZY-KJS-2022-038-3)
河南省“双一流”创建学科中医学科学研究专项项目(HSRP-DFCTCM-2023-6-04)
2022年度河南省中医药科学研究专项项目(2022ZY1175)

参考文献

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2026年第54卷第10期

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文章信息

doi: 10.19664/j.cnki.1002-2392.260214

接收时间：2025-07-01
首发时间：2026-10-14
出版时间：2026-10-20

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出版历史

收稿日期：2025-07-01
修回日期：2026-03-14

基金

国家中医药管理局科技项目(GZY-KJS-2022-038-3)

河南省“双一流”创建学科中医学科学研究专项项目(HSRP-DFCTCM-2023-6-04)

2022年度河南省中医药科学研究专项项目(2022ZY1175)

作者信息

河南中医药大学中医学院，河南　郑州　450046

通讯作者:

^* 郑攀（1977-），男，博士，教授，硕士生导师，研究方向：方剂作用机制与配伍规律。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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