Article(id=1317114972518334755, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1317114959243362461, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260206, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1750003200000, receivedDateStr=2025-06-16, revisedDate=1777219200000, revisedDateStr=2026-04-27, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954280261, onlineDateStr=2026-10-14, pubDate=1792425600000, pubDateStr=2026-10-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954280261, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954280261, creator=13701087609, updateTime=1791954280261, updator=13701087609, issue=Issue{id=1317114959243362461, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='10', pageStart='1', pageEnd='137', issueExtLink='null', onlineDate='null', pubDate='1792425600000', pubDateStr='2026-10-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1791954277096, creator='13701087609', updateTime=1792120134547, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317810615909991147, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1317114959243362461, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317810615909991148, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1317114959243362461, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=76, endPage=81, ext={EN=ArticleExt(id=1317114972698689828, articleId=1317114972518334755, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Effect of Modified Huangqi Jianzhong Decoction on Postoperative Intestinal Function Recovery After Laparoscopic Colorectal Cancer Surgery, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate the effects of modified Huangqi Jianzhong Decoction combined with conventional treatment on intestinal function, intestinal barrier, and immune-inflammatory status in patients after laparoscopic colorectal cancer surgery, and to provide evidence-based support for enhanced recovery.
Methods: A total of 96 patients who underwent laparoscopic radical resection for colorectal cancer at Wujin Affiliated Hospital of Nanjing University of Chinese Medicine from February 2022 to March 2025 were randomly divided into an observation group and a control group, with 48 cases in each group. The control group received conventional treatment. On this basis, the observation group was additionally given modified Huangqi Jianzhong Decoction starting from the first day after surgery, one dose per day for 7 consecutive days. Clinical efficacy was compared between the two groups. Traditional Chinese Medicine (TCM) syndrome scores, intestinal barrier function indicators (diamine oxidase [DAO], D-lactic acid [D-Lac], intestinal fatty acid-binding protein [IFABP]), immune-inflammatory indicators (CD4+/CD8+ ratio, natural killer [NK] cell activity, regulatory T cells [Treg], IL-10/IL-6 ratio), and the Gastrointestinal Symptom Rating Scale (GSRS) scores were compared before surgery and 7 days after surgery. Postoperative complications and adverse events were also recorded.
Results: On postoperative day 7, the total effective rate in the observation group was 95.83% (46/48), which was significantly higher than that in the control group (72.92%, 35/48) (P<0.01). Compared with postoperative day 1, the levels of DAO, D-Lac, and IFABP in both groups decreased on postoperative day 7 (P<0.05), and the levels in the observation group were significantly lower than those in the control group (P<0.05). The CD4+/CD8+ ratio, NK cell activity, Treg percentage, and IL-10/IL-6 ratio increased significantly in both groups (P<0.05), with the observation group showing significantly higher values than the control group (P<0.05). The scores for abdominal pain, abdominal distension, difficulty in passing flatus, nausea/reflux, and defecation disorder in the observation group were significantly lower than those in the control group (P<0.01). In the control group, one patient experienced postoperative nausea and dizziness, and one patient developed pruritic erythema; in the observation group, one patient experienced nausea and decreased appetite. There was no significant difference in adverse events between the two groups (P>0.05). The incidence of complications in the observation group was 6.25% (3/48), which was significantly lower than that in the control group (20.83%, 10/48) (P<0.05).
Conclusion: Adding modified Huangqi Jianzhong Decoction to conventional treatment can significantly improve intestinal barrier function, immune-inflammatory balance, and gastrointestinal symptoms in patients after laparoscopic colorectal cancer surgery, and reduce the incidence of complications, with a favorable safety profile.
, authors=Chenghao GUO, Jian'gang ZHOU, Rong SHAO, Xin YE, Jie ZHAO
*, authorsList=Chenghao GUO, Jian'gang ZHOU, Rong SHAO, Xin YE, Jie ZHAO, authorCompany=null, correspAuthors=Jie ZHAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317114973067788581, articleId=1317114972518334755, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=黄芪建中汤加减对腹腔镜结直肠癌术后肠功能恢复的影响, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探讨黄芪建中汤加减联合常规治疗对腹腔镜结直肠癌术后患者肠功能、肠道屏障及免疫-炎症状态的影响，为加速康复提供循证依据。
方法： 纳入2022年2月—2025年3月南京中医药大学武进附属医院收治的行腹腔镜结直肠癌根治术患者96例，随机分为观察组与对照组，每组48例。对照组实施常规治疗方案；观察组在此基础上自术后首日起加用黄芪建中汤加减，每日1剂，连续服用7 d。比较两组临床疗效，对比术前与术后7 d两组中医证候积分，肠道屏障功能指标（二胺氧化酶DAO、D-乳酸D-Lac、脂肪酸结合蛋白IFABP），免疫-炎症指标（CD4+/CD8+、NK细胞活性、调节性T细胞Treg、IL-10/IL-6），并评估胃肠道症状分级量表GSRS评分；同期记录术后并发症与不良事件。
结果： 术后7 d统计，观察组患者总有效率为95.83%（46/48），高于对照组的72.92%（35/48），差异有统计学意义（P<0.01）。与术后第1天比较，术后第7天两组患者DAO、D-Lac及IFABP水平均降低（P<0.05），且观察组水平均低于对照组（P<0.05）。两组患者CD4+/CD8+、NK细胞活性、Treg比例及IL-10/IL-6比值均升高（P<0.05），且观察组均高于对照组（P<0.05）。观察组患者腹痛、腹胀、排气困难、恶心反流及排便紊乱评分均低于对照组（P<0.01）。对照组出现1例术后恶心、眩晕，1例瘙痒性红斑；观察组出现1例恶心、食欲下降，两组比较，差异无统计学意义（P>0.05）。观察组患者并发症发生率为6.25%（3/48），低于对照组的20.83%（10/48），差异有统计学意义（P<0.05）。
结论： 在常规治疗基础上加用黄芪建中汤加减可显著改善腹腔镜结直肠癌术后患者的肠道屏障功能、免疫-炎症平衡与胃肠症状，降低并发症发生率，安全可行。
, authors=郭程昊, 周建刚, 邵荣, 叶欣, 赵杰
*, authorsList=郭程昊, 周建刚, 邵荣, 叶欣, 赵杰, authorCompany=null, correspAuthors=赵杰, authorNote=
郭程昊（1996-），男，硕士，住院医师，从事肝胆及胃肠疾病相关研究。
, correspAuthorsNote=
* 赵杰（1988-），男，副主任医师，从事肝胆及胃肠疾病相关研究。
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郭程昊（1996-），男，硕士，住院医师，从事肝胆及胃肠疾病相关研究。
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郭程昊（1996-），男，硕士，住院医师，从事肝胆及胃肠疾病相关研究。
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