Article(id=1317114965752922329, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1317114959243362461, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260212, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1762790400000, receivedDateStr=2025-11-11, revisedDate=1777910400000, revisedDateStr=2026-05-05, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954278647, onlineDateStr=2026-10-14, pubDate=1792425600000, pubDateStr=2026-10-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954278647, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954278647, creator=13701087609, updateTime=1791954278647, updator=13701087609, issue=Issue{id=1317114959243362461, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='10', pageStart='1', pageEnd='137', issueExtLink='null', onlineDate='null', pubDate='1792425600000', pubDateStr='2026-10-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1791954277096, creator='13701087609', updateTime=1792120134547, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317810615909991147, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1317114959243362461, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317810615909991148, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1317114959243362461, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=111, endPage=116, ext={EN=ArticleExt(id=1317114965966831835, articleId=1317114965752922329, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Correlation Analysis of Cytokine Levels with Traditional Chinese Medicine Syndromes and Therapeutic Efficacy in Cervical-Cancer Patients with Radiation-Induced Vaginitis Treated by Heat-Clearing and Detoxifying Herbal Irrigation, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate the correlation among cytokine levels, traditional Chinese medicine (TCM) syndromes, and clinical efficacy in patients with radiation-induced vaginitis after cervical cancer who were treated with heat-clearing and detoxifying herbal irrigation.
Methods: A total of 124 patients with radiation-induced vaginitis following cervical cancer admitted to our hospital from February 2023 to May 2025 were enrolled and randomly divided into a control group (n=62, receiving conventional vaginal douching) and an observation group (n=62, receiving heat-clearing and detoxifying herbal irrigation). Curative effect, adverse reactions, cytokine levels, TCM syndrome scores, and the correlations between cytokines and TCM syndromes or efficacy in the observation group were evaluated before and after treatment.
Results: Following treatment, the observation group's (93.55 percent) overall effective rate was significantly greater than the control group's (80.64 percent) (P<0.05), and both groups' total effective rates exceeded 80%. There was no statistically significant difference between the observation group's (3.22 percent, P>0.05) and control group's (8.05 percent) overall incidence of adverse responses. Post-treatment, cytokine levels declined significantly in both groups (P<0.05), with the observation group experiencing a larger decline (P<0.05). All TCM syndrome scores were improved after treatment (P<0.05), and the improvement was superior in the observation group (P<0.05). In the observation group after treatment, only “profuse leukorrhea” showed a significant negative correlation with IL-6 level (P<0.01), while “yellow color with foul fishy odor” was positively correlated with IL-8 level (P<0.01).
Conclusion: Heat-clearing and detoxifying herbal irrigation can effectively ameliorate inflammatory symptoms and TCM syndromes in patients with radiation-induced vaginitis after cervical cancer, demonstrating favorable efficacy and safety, and is worthy of clinical application and promotion. The correlation results suggest that its mechanism may involve down-regulating inflammatory cytokines, thereby improving TCM syndromes and ultimately achieving better clinical outcomes.
, authors=Qingwen WANG, Lei GAO, Yongxia ZHANG, Jianwei HU, Junjun MIAO, Pengcheng XU
*, authorsList=Qingwen WANG, Lei GAO, Yongxia ZHANG, Jianwei HU, Junjun MIAO, Pengcheng XU, authorCompany=null, correspAuthors=Pengcheng XU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317114966289793244, articleId=1317114965752922329, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=清热解毒中药灌洗宫颈癌放射性阴道炎患者细胞因子水平及与中医证候、疗效的相关性分析, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探究清热解毒中药灌洗的宫颈癌放射性阴道炎患者细胞因子水平及与中医证候、疗效的相关性。
方法： 根据随机数字表法将河北省沧州中西医结合医院2023年2月—2025年5月收治的宫颈癌放射性阴道炎患者124例随机分为对照组（62例，常规阴道冲洗治疗）和观察组（62例，清热解毒中药灌洗治疗），并对治疗效果、安全性以及观察组治疗后细胞因子水平及与中医证候、疗效的相关性进评估。
结果： 治疗后两组总有效率均高于80%，观察组有效率93.55%（58/62）显著高于对照组的80.64%（50/62），差异有统计学意义（P<0.05）；对照组总不良反应发生率为8.05%（5/62），高于观察组的3.22%（2/62），但差异无统计学意义（P>0.05）；治疗后，两组细胞因子水平均下降（P<0.05），且观察组下降程度更高（P<0.05）；治疗后，两组各项中医证候评分均下降（P<0.05），且观察组改善程度优于对照组（P<0.05）；观察组治疗后仅有带下量多与IL-6水平呈显著负相关（P<0.01）、色黄味腥臭与IL-8水平呈显著正相关（P<0.01）。
结论： 清热解毒中药灌洗能够有效改善宫颈癌放射性阴道炎患者炎症症状和中医证候，具有较好的有效性和安全性，展现出在临床实践中应用及推广的潜力。相关性结果可在一定程度推测其作用机制可能为下调炎症细胞因子水平进而改善中医证候，最终发挥较好的临床疗效。
, authors=王晴雯, 郜蕾, 张永侠, 胡建伟, 苗珺珺, 许鹏成
*, authorsList=王晴雯, 郜蕾, 张永侠, 胡建伟, 苗珺珺, 许鹏成, authorCompany=null, correspAuthors=许鹏成, authorNote=
王晴雯（1989-），女，硕士，主治医师，从事中医肿瘤相关研究。
, correspAuthorsNote=
* 许鹏成（1991-），男，硕士，主治医师，从事外科学相关研究。
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王晴雯（1989-），女，硕士，主治医师，从事中医肿瘤相关研究。
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王晴雯（1989-），女，硕士，主治医师，从事中医肿瘤相关研究。
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