Article(id=1317114961256624732, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1317114959243362461, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260198, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1752336000000, receivedDateStr=2025-07-13, revisedDate=1777910400000, revisedDateStr=2026-05-05, acceptedDate=null, acceptedDateStr=null, onlineDate=1791954277575, onlineDateStr=2026-10-14, pubDate=1792425600000, pubDateStr=2026-10-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791954277575, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791954277575, creator=13701087609, updateTime=1791954277575, updator=13701087609, issue=Issue{id=1317114959243362461, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='10', pageStart='1', pageEnd='137', issueExtLink='null', onlineDate='null', pubDate='1792425600000', pubDateStr='2026-10-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1791954277096, creator='13701087609', updateTime=1792120134547, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317810615909991147, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1317114959243362461, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317810615909991148, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1317114959243362461, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=27, endPage=35, ext={EN=ArticleExt(id=1317114961436979805, articleId=1317114961256624732, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Study on the Advantages of the Synergistic Effect of the Thirteen Methods for Processing Cyperi Rhizoma Based on Multi-dimensional Pharmacodynamic Comparison, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To compare the superior processing synergistic efficacy of Thirteen-processed Cyperi Rhizoma with Xiushan characteristic processing technology, and to provide a research basis for the modern industrial improvement of regional characteristic processed TCM products.
Methods: On the basis of inheriting the unique Xiushan processing technology for Thirteen-processed Cyperi Rhizoma, multiple rat models of traditional Chinese medicine syndromes were established, including primary dysmenorrhea, threatened abortion with uterine hemorrhage, and liver depression, qi stagnation and blood stasis. The therapeutic advantages of this regional characteristic processed product were comprehensively compared with those of clinically commonly-used processed products in modern practice and representative processed varieties recorded in successive dynasties.
Results: Thirteen-processed Cyperi Rhizoma significantly reduced the writhing times (P<0.05, P<0.01), decreased the uterine organ coefficient (P<0.05, P<0.01), and lowered serum levels of PGF2α, GnRH and LH (P<0.05) in mice with primary dysmenorrhea. It also remarkably relieved vaginal bleeding volume and reduced FSH and LH levels (P<0.05) in the rat model of threatened abortion with uterine hemorrhage. In addition, it significantly decreased whole blood high-, medium-and low-shear viscosity, plasma viscosity, as well as serum ALT and AST levels (P<0.05) in rats with liver depression, qi stagnation and blood stasis.
Conclusion: As an inheritance of local characteristic processing technology, Thirteen-processed Cyperi Rhizoma is insufficient in repairing substantial organic lesions. However, it presents prominent processing potentiating effects in the intervention and treatment of primary dysmenorrhea, threatened abortion with uterine hemorrhage, and liver depression, qi stagnation and blood stasis. It can be regarded as a distinctive processed medicinal material for further in-depth research and modern industrial transformation and optimization.
, authors=Dijia ZHAO
1, Li XIANG
1, Min YANG
1, Yongai XIONG
2, Wenhui WU
1, *, authorsList=Dijia ZHAO, Li XIANG, Min YANG, Yongai XIONG, Wenhui WU, authorCompany=null, correspAuthors=Wenhui WU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317114961701220958, articleId=1317114961256624732, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=基于多维度药效学比较的香附十三制法炮制增效作用优势研究, columnId=1303760926633652690, journalTitle=中医药学报, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 比较秀山特色炮制技术十三制香附的优势炮制增效作用，为特色地方炮制品的现代工业改良提供研究基础。
方法： 基于秀山特色炮制技术十三制香附的传承，通过构建小鼠原发性痛经、先兆流产子宫出血、肝郁气滞血瘀等多种中医证候模型，综合比较该地方特色炮制品与现代临床常用炮制品、历代炮制代表品种的治疗优势。
结果： 十三制香附可显著减少小鼠原发性痛经模型扭体次数（P<0.05，P<0.01）、降低子宫脏器系数（P<0.05，P<0.01）以及血清PGF2α、GnRH和LH水平（P<0.05）；显著减少小鼠先兆流产子宫出血模型阴道出血量（P<0.05）、降低血清FSH、LH水平（P<0.05）；显著降低小鼠肝郁气滞血瘀模型血液高、中、低切黏度、血浆黏度、血清ALT、AST水平（P<0.05）。
结论： 十三制香附作为地方特色炮制技术的传承，虽在器官实质性病变修复上存在不足，但在原发性痛经、先兆流产子宫出血、肝郁气滞血瘀的治疗中展现出显著的炮制增效作用，可以作为特色炮制品进行深入研究和现代工业改良。
, authors=赵迪加
1, 向丽
1, 杨敏
1, 熊永爱
2, 吴文辉
1, *, authorsList=赵迪加, 向丽, 杨敏, 熊永爱, 吴文辉, authorCompany=null, correspAuthors=吴文辉, authorNote=
赵迪加（1978-），男，硕士，研究实习员，从事中药药剂学相关研究。
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* 吴文辉（1986-），男，博士，副主任中药师，从事中药炮制原理相关研究。
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1.Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1317504339648823917, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1317114961256624732, authorId=1317504338931597930, language=CN, stringName=赵迪加, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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赵迪加（1978-），男，硕士，研究实习员，从事中药药剂学相关研究。
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赵迪加（1978-），男，硕士，研究实习员，从事中药药剂学相关研究。
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