Article(id=1307269696668065855, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269637637427792, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260085, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1734537600000, receivedDateStr=2024-12-19, revisedDate=1737475200000, revisedDateStr=2025-01-22, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606983581, onlineDateStr=2026-09-17, pubDate=1776614400000, pubDateStr=2026-04-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606983581, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606983581, creator=13701087609, updateTime=1789606983581, updator=13701087609, issue=Issue{id=1307269637637427792, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='4', pageStart='1', pageEnd='127', issueExtLink='null', onlineDate='null', pubDate='1776614400000', pubDateStr='2026-04-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606969508, creator='13701087609', updateTime=1789606969508, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=106, endPage=111, ext={EN=ArticleExt(id=1307269696840032320, articleId=1307269696668065855, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Effect of Yangyin Runfei Qingzao Decoction Combined with Pirfenidone on Patients with Idiopathic Pulmonary Fibrosis, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To observe the effect of Yangyin Runfei Qingzao Decoction combined with pirfenidone on patients with idiopathic pulmonary interstitial fibrosis.
Methods: A total of 100 patients with idiopathic pulmonary fibrosis were selected from Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei Province. They were enrolled from September 2020 to September 2023. They were grouped by random number table method. 50 patients in pirfenidone group (1 case dropped, 49 cases eventually included) were given pirfenidone capsule treatment, and 50 patients in the combined Chinese medicine group (1 case dropped, 1 case excluded, 48 cases eventually included) were given pirfenidone capsule treatment. The pirfenidone group was treated with Yangyin Runfei Qingzao Decoction at the same time. After treatment, the clinical efficacy of the two groups was compared, the 6 min walking distance (6MWT) was measured before and after treatment, and the patients were evaluated with St. George's Respiratory Questionnaire (SGRQ) and idiopathic pulmonary fibrosis Patient Quality of Life Scale (ATAQ-IPF). The levels of total lung volume (TLC), arterial oxygen saturation (SaO2), maximum mid-expiratory flow (MMF), and pulmonary carbon monoxide dispersion (DLco) were measured. Serum levels of IGFBP-5, CYFRA21-1, osteopontin, fibroblast growth factor (FGF -21), chemokine ligand 14 (CXCL14), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), CD4+and CD8+ were detected.
Results: The total effective rate of Chinese medicine combined group was higher than that of pirfenidone group (P <0.05). The expression levels of 6MWT, SGRQ score, TLC, SaO2, FGF -21, MMF, GSH-Px, DLCO and CD4+ in Chinese medicine combined group were higher than those in pirfenidone group (P < 0.05). ATAQ-IPF score, CD8+, CXCL14, MDA, IGFBP-5, Cyfra21-1 and osteopontin expression in the Chinese medicine group were lower than those in pirfenidone group (P < 0.05).
Conclusion: The combination therapy of Yangyin Runfei Qingzao Decoction and pirfenidone in patients with idiopathic pulmonary fibrosis can reduce inflammation and oxidative injury, improve immune function, alleviate pulmonary fibrosis, and enhance patients' quality of life, exercise tolerance, and clinical efficacy.
, authors=Xiaojuan YOU, Ningning XU, Lei PAN, authorsList=Xiaojuan YOU, Ningning XU, Lei PAN, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269697280434241, articleId=1307269696668065855, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=养阴润肺清燥汤联合吡非尼酮对特发性肺间质纤维化患者的影响, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 观察养阴润肺清燥汤联合吡非尼酮对特发性肺间质纤维化患者的影响。
方法： 选择2020年9月—2023年9月于河北省沧州中西医结合医院治疗的特发性肺纤维化患者100例，随机数字表法分为吡非尼酮组50例（脱落1例，最终纳入49例），给予吡非尼酮胶囊治疗，合并中药组50例（脱落1例，剔除1例，最终纳入48例），在吡非尼酮组的基础上加用养阴润肺清燥汤治疗，治疗后比较两组临床疗效，治疗前后检测6 min步行距离（6 MWT），给予患者圣乔治呼吸问卷（SGRQ）、特发性肺纤维化患者生活质量量表（ATAQ-IPF）评价，检测患者肺总量（TLC）、动脉血氧饱和度（SaO2）、最大呼气中段流量（MMF）、肺一氧化碳弥散量（DLco）水平，检测血清IGFBP -5、CYFRA21 -1、骨桥蛋白、成纤维细胞生长因子（FGF -21）、趋化因子配体14（CXCL14）、丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）、CD4+、CD8+水平。
结果： 合并中药组总有效率高于吡非尼酮组（P < 0.05）；合并中药组6 MWT、SGRQ评分、TLC、SaO2、FGF -21、MMF、GSH-Px、DLCO、CD4+表达水平高于吡非尼酮组（P < 0.05），合并中药组ATAQ-IPF评分、CD8+、CXCL14、MDA、IGFBP-5、Cyfra21-1、骨桥蛋白表达低于吡非尼酮组（P <0.05）。
结论： 给予特发性肺间质纤维化患者养阴润肺清燥汤联合吡非尼酮治疗，可减少炎症及氧化损伤，改善免疫指标，减少肺纤维化，提升患者生活质量、运动耐力及临床疗效。
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尤晓娟（1991-），女，硕士，主治医师，从事呼吸病学的临床研究。
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尤晓娟（1991-），女，硕士，主治医师，从事呼吸病学的临床研究。
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尤晓娟（1991-），女，硕士，主治医师，从事呼吸病学的临床研究。
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