Article(id=1307269680989762354, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269637637427792, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260087, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1730563200000, receivedDateStr=2024-11-03, revisedDate=1756396800000, revisedDateStr=2025-08-29, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606979844, onlineDateStr=2026-09-17, pubDate=1776614400000, pubDateStr=2026-04-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606979844, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606979844, creator=13701087609, updateTime=1789606979844, updator=13701087609, issue=Issue{id=1307269637637427792, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='4', pageStart='1', pageEnd='127', issueExtLink='null', onlineDate='null', pubDate='1776614400000', pubDateStr='2026-04-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606969508, creator='13701087609', updateTime=1789606969508, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=119, endPage=127, ext={EN=ArticleExt(id=1307269684781413171, articleId=1307269680989762354, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Research Progress on Traditional Chinese Medicine Regulating Programmed Cell Death Pathways to Intervene in Sepsis-Induced Intestinal Dysfunction, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Sepsis is a systemic inflammatory response syndrome triggered by infection, characterized by complex pathology, high treatment difficulty, and high mortality, making it one of the challenges in clinical treatment. Among its complications, intestinal dysfunction, as a common complication of sepsis, is not only a key factor leading to multiple organ dysfunction syndrome (MODS) but also often results in poor prognosis due to its insidious nature and suboptimal therapeutic efficacy, further increasing the complexity and urgency of treatment. Traditional Chinese medicine (TCM), with its holistic regulatory approach and multi-pathway, multi-target characteristics, offers new strategies for the treatment of sepsis-induced intestinal dysfunction. In terms of mechanistic research, programmed cell death (PCD) plays a critical role in the pathological process of intestinal dysfunction by mediating the death of immune cells and intestinal epithelial cells. In recent years, TCM's intervention in sepsis-induced intestinal dysfunction by regulating PCD pathways has garnered widespread attention. This article summarizes recent relevant literature to review the effects and mechanisms of TCM and its active components in improving sepsis-induced intestinal dysfunction through intervention in PCD pathways, aiming to provide references and basis for the clinical treatment of sepsis-induced intestinal dysfunction.

, authors=Yuanyuan LV^{1, 2, 3}, Haoran YE^{1, 2, 3}, Jin SONG^{1, 2}, Jin CUI¹, Shasha HE^{1, 2, 3, *}, authorsList=Yuanyuan LV, Haoran YE, Jin SONG, Jin CUI, Shasha HE, authorCompany=null, correspAuthors=Shasha HE, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269685209232180, articleId=1307269680989762354, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=中医药调控程序性细胞死亡途径干预脓毒症肠功能障碍的研究进展, columnId=1303760941036888710, journalTitle=中医药学报, columnName=研究进展, runingTitle=null, highlight=null, articleAbstract=

脓毒症是一种由感染引发的全身炎症反应综合征，其病情复杂、治疗难度大、病死率高，是临床治疗的难点之一。其中，肠功能障碍作为脓毒症的常见并发症，不仅是导致脓毒症多器官功能障碍综合征（MODS）的关键因素，还因其隐蔽性和疗效不佳常导致预后不良，进一步增加了治疗的复杂性和紧迫性。中医药以其整体调节和多途径、多靶点的特点，为脓毒症肠功能障碍的治疗提供了新思路。在其机制研究方面，程序性细胞死亡（PCD）通过介导免疫细胞和肠上皮细胞的死亡，在肠功能障碍的病理过程中发挥重要作用，近年来受到广泛关注。本文通过总结近年来相关文献，综述了中药及其有效成分通过干预PCD途径，改善脓毒症肠功能障碍的作用及机制，以期为其临床治疗提供参考和依据。

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吕媛媛（2000-），女，硕士研究生，从事中医药防治感染性疾病机制研究。

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