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Article(id=1307269675444892412, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269637637427792, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260077, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1710864000000, receivedDateStr=2024-03-20, revisedDate=1725984000000, revisedDateStr=2024-09-11, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606978522, onlineDateStr=2026-09-17, pubDate=1776614400000, pubDateStr=2026-04-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606978522, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606978522, creator=13701087609, updateTime=1789606978522, updator=13701087609, issue=Issue{id=1307269637637427792, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='4', pageStart='1', pageEnd='127', issueExtLink='null', onlineDate='null', pubDate='1776614400000', pubDateStr='2026-04-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606969508, creator='13701087609', updateTime=1789606969508, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=61, endPage=66, ext={EN=ArticleExt(id=1307269675591693053, articleId=1307269675444892412, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Origin Verification and Compatibility Analysis of the Draconis Os and Ostreae Concha Couplet Medicinals, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To provide theoretical basis for basic research and clinical application of traditional Chinese medicine by analyzing the origins and characteristics of the compatibility of the Draconis Os and Ostreae Concha couplet medicinals.

Methods:

Formulae involving the Draconis Os and Ostreae Concha couplet medicinals were collected and organized from the Chinese Medical Classics. Based on the theory of couplet medicinals compatibility, this study examines and verifies the origin of the Draconis Os and Ostreae Concha couplet medicinals from the perspective of historical application and compatibility mechanisms, and summarizes the usage characteristics including primary indications, dosage ratios, and preparation methods.

Results:

A total of 382 formulae containing the Draconis Os and Ostreae Concha couplet medicinals were identified, with applications in the treatment of mental disorders beginning from the Han Dynasty. Numerous classical texts record that this couplet medicinals is commonly used in equal ratios and the preparation methods often include, but are not limited to, fire processing. Historically and in modern clinical practice, this couplet medicinals is widely used across various fields including internal medicine, gynecology, and andrology. Modern research focuses on analyzing the effective components for calming the mind and their clinical therapeutic effects.

Conclusion:

The Draconis Os and Ostreae Concha couplet medicinals has a broad clinical application potential, with a long history and rich experience in treating mental disorders. This research can provide valuable insights for modern clinical treatment and basic research in TCM.

, authors=Ruolan KONG1, Jinye YUAN1, Shuxian WANG1, Chenxin HE1, Yan ZHAO1, Huihua QU2, *, authorsList=Ruolan KONG, Jinye YUAN, Shuxian WANG, Chenxin HE, Yan ZHAO, Huihua QU, authorCompany=null, correspAuthors=Huihua QU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269676002734847, articleId=1307269675444892412, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=龙骨-牡蛎药对源流考证及配伍探析, columnId=1307269675679773438, journalTitle=中医药学报, columnName=方剂纵横, runingTitle=null, highlight=null, articleAbstract=
目的：

通过分析龙骨-牡蛎药对配伍历史源流及特征，为中医药基础研究及临床应用提供理论基础。

方法：

搜集整理《中华医典》中龙骨与牡蛎同方配伍的方剂。基于药对配伍理论，从应用历史与配伍机制方面梳理、考证龙骨-牡蛎药对的历史源流，总结分析该药对的应用主治、配伍剂量比例、炮制方法等。

结果：

整理分析得到含有龙骨-牡蛎药对的方剂共382首，该药对从汉代开始应用于神志疾病的治疗。众多典籍记载该药对在临床上多为等比配伍使用，炮制方法多为但不局限于火制法。历代医家及现代临床上多应用此药对治疗内科、妇科、男科等疾病。该药对的现代研究集中于镇惊安神有效成分的分析及临床治疗效果的分析。

结论：

龙骨-牡蛎药对有广泛的临床应用前景，在治疗神志疾病方面历史悠久且有丰富的经验，可为现代临床疾病的治疗及中医药的基础研究提供借鉴。

, authors=孔若岚1, 院金烨1, 王淑贤1, 何晨昕1, 赵琰1, 屈会化2, *, authorsList=孔若岚, 院金烨, 王淑贤, 何晨昕, 赵琰, 屈会化, authorCompany=null, correspAuthors=屈会化, authorNote=

孔若岚（1999-），女，硕士研究生，研究方向：经方的现代应用。

, correspAuthorsNote=
* 屈会化（1966-），男，博士，研究员，博士生导师，研究方向：经方的现代应用。
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孔若岚（1999-），女，硕士研究生，研究方向：经方的现代应用。

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孔若岚（1999-），女，硕士研究生，研究方向：经方的现代应用。

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龙骨-牡蛎药对源流考证及配伍探析
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孔若岚 1 , 院金烨 1 , 王淑贤 1 , 何晨昕 1 , 赵琰 1 , 屈会化 2, *
中医药学报 | 方剂纵横 2026,54(4): 61-66
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中医药学报 |方剂纵横 2026 , 54 (4) : 61 -66
龙骨-牡蛎药对源流考证及配伍探析
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孔若岚1, 院金烨1, 王淑贤1, 何晨昕1, 赵琰1, 屈会化2, *
作者信息
  • 1.北京中医药大学中医学院，北京 100029
  • 2.北京中医药大学中医药研究院，北京 100029
通讯作者:
* 屈会化（1966-），男，博士，研究员，博士生导师，研究方向：经方的现代应用。
作者简介:

孔若岚（1999-），女，硕士研究生，研究方向：经方的现代应用。

Origin Verification and Compatibility Analysis of the Draconis Os and Ostreae Concha Couplet Medicinals
Ruolan KONG1, Jinye YUAN1, Shuxian WANG1, Chenxin HE1, Yan ZHAO1, Huihua QU2, *
Affiliations
  • 1.School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
  • 2.Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
出版时间: 2026-04-20 doi: 10.19664/j.cnki.1002-2392.260077
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摘要
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目的：

通过分析龙骨-牡蛎药对配伍历史源流及特征，为中医药基础研究及临床应用提供理论基础。

方法：

搜集整理《中华医典》中龙骨与牡蛎同方配伍的方剂。基于药对配伍理论，从应用历史与配伍机制方面梳理、考证龙骨-牡蛎药对的历史源流，总结分析该药对的应用主治、配伍剂量比例、炮制方法等。

结果：

整理分析得到含有龙骨-牡蛎药对的方剂共382首，该药对从汉代开始应用于神志疾病的治疗。众多典籍记载该药对在临床上多为等比配伍使用，炮制方法多为但不局限于火制法。历代医家及现代临床上多应用此药对治疗内科、妇科、男科等疾病。该药对的现代研究集中于镇惊安神有效成分的分析及临床治疗效果的分析。

结论：

龙骨-牡蛎药对有广泛的临床应用前景，在治疗神志疾病方面历史悠久且有丰富的经验，可为现代临床疾病的治疗及中医药的基础研究提供借鉴。

龙骨  /  牡蛎  /  药对配伍  /  源流  /  机制  /  配伍特征
Objective:

To provide theoretical basis for basic research and clinical application of traditional Chinese medicine by analyzing the origins and characteristics of the compatibility of the Draconis Os and Ostreae Concha couplet medicinals.

Methods:

Formulae involving the Draconis Os and Ostreae Concha couplet medicinals were collected and organized from the Chinese Medical Classics. Based on the theory of couplet medicinals compatibility, this study examines and verifies the origin of the Draconis Os and Ostreae Concha couplet medicinals from the perspective of historical application and compatibility mechanisms, and summarizes the usage characteristics including primary indications, dosage ratios, and preparation methods.

Results:

A total of 382 formulae containing the Draconis Os and Ostreae Concha couplet medicinals were identified, with applications in the treatment of mental disorders beginning from the Han Dynasty. Numerous classical texts record that this couplet medicinals is commonly used in equal ratios and the preparation methods often include, but are not limited to, fire processing. Historically and in modern clinical practice, this couplet medicinals is widely used across various fields including internal medicine, gynecology, and andrology. Modern research focuses on analyzing the effective components for calming the mind and their clinical therapeutic effects.

Conclusion:

The Draconis Os and Ostreae Concha couplet medicinals has a broad clinical application potential, with a long history and rich experience in treating mental disorders. This research can provide valuable insights for modern clinical treatment and basic research in TCM.

Draconis Os  /  Ostreae Concha  /  Couplet medicinals compatibility  /  Origin  /  Mechanism  /  Compatibility characteristics
孔若岚, 院金烨, 王淑贤, 何晨昕, 赵琰, 屈会化. 龙骨-牡蛎药对源流考证及配伍探析. 中医药学报, 2026 , 54 (4) : 61 -66 . DOI: 10.19664/j.cnki.1002-2392.260077
Ruolan KONG, Jinye YUAN, Shuxian WANG, Chenxin HE, Yan ZHAO, Huihua QU. Origin Verification and Compatibility Analysis of the Draconis Os and Ostreae Concha Couplet Medicinals[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (4) : 61 -66 . DOI: 10.19664/j.cnki.1002-2392.260077
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  • 国家中医药管理局青年岐黄学者支持项目(90020172120064)
  • 中央高校基本科研业务费专项资金资助项目(90011451310030)
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doi: 10.19664/j.cnki.1002-2392.260077
  • 接收时间：2024-03-20
  • 首发时间：2026-09-17
  • 出版时间：2026-04-20
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  • 收稿日期：2024-03-20
  • 修回日期：2024-09-11
基金
国家中医药管理局青年岐黄学者支持项目(90020172120064)
中央高校基本科研业务费专项资金资助项目(90011451310030)
作者信息
    1.北京中医药大学中医学院，北京 100029
    2.北京中医药大学中医药研究院，北京 100029

通讯作者:

* 屈会化（1966-），男，博士，研究员，博士生导师，研究方向：经方的现代应用。
参考文献
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https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260077
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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