Article(id=1307269666171286207, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269637637427792, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260082, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1748448000000, receivedDateStr=2025-05-29, revisedDate=1765036800000, revisedDateStr=2025-12-07, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606976311, onlineDateStr=2026-09-17, pubDate=1776614400000, pubDateStr=2026-04-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606976311, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606976311, creator=13701087609, updateTime=1789606976311, updator=13701087609, issue=Issue{id=1307269637637427792, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='4', pageStart='1', pageEnd='127', issueExtLink='null', onlineDate='null', pubDate='1776614400000', pubDateStr='2026-04-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606969508, creator='13701087609', updateTime=1789606969508, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=89, endPage=94, ext={EN=ArticleExt(id=1307269666364224192, articleId=1307269666171286207, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=A Randomized Crossover Trial Study on Modified Shangqing Powder in the Treatment of Acute-phase Migraine, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To observe the clinical efficacy of modified Shangqing powder with channel-guiding herbs in the treatment of acute migraine attacks.
Methods: A total of 47 patients with acute migraine attacks who visited the outpatient department of Encephalopathy at Dongzhimen Hospital, Beijing University of Chinese Medicine between July 2023 and June 2024 were selected and divided into Group A and B using a random number table method. In the first phase (P1), Group A received Shangqing powder combined with ibuprofen, while Group B received a placebo combined with ibuprofen. After a washout period, the two groups switched treatments in the second phase (P2). Each patient received both intervention methods sequentially. The effective rate of treatment, VAS scores and accompanying symptom scores before and 2 hours, 24 hours after treatment, and short-term recurrence of migraine within 24 h and 72 h after medication were observed. The possible target points were further explored by comparing the changes of serum indicators before and after treatment.
Results: In the P1, there were significant between-group differences in accompanying symptom scores at 24 hours, VAS scores at 24 hours, and the degree of reduction in VAS scores at 24 hours (P < 0.05). The difference in serum nitric oxide (NO) levels before and after treatment also showed significant between-group differences (P < 0.05, P < 0.01). In the P2, there were no statistically significant differences in VAS scores at 2 hours and 24 hours or accompanying symptom scores between the groups(P > 0.05). Across both phases, the efficacy rate of Shangqing powder at 2 hours post-treatment was 72.20%, significantly higher than the placebo's 34.20% (χ2 =10.716, P =0.001). Significant differences were observed in VAS scores at 24 hours and accompanying symptom scores at 2 hours and 24 hours post-treatment (P <0.05), and the migraine recurrence rate within 72 hours was reduced (P <0.01).
Conclusion: Shangqing powder demonstrates good clinical efficacy in the treatment of acute migraine attacks, providing clinical reference for the intervention of migraines with traditional Chinese medicine.
, authors=Yikun LU, Xiao HAN, Ying ZHOU, Huawei SHI, Fang WANG, Jing BAI, Xinglu DONG, Yuying FAN, Fangyuan CUI
*, authorsList=Yikun LU, Xiao HAN, Ying ZHOU, Huawei SHI, Fang WANG, Jing BAI, Xinglu DONG, Yuying FAN, Fangyuan CUI, authorCompany=null, correspAuthors=Fangyuan CUI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269666745905857, articleId=1307269666171286207, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=上清散加味治疗偏头痛急性期的随机交叉试验研究, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 观察上清散加味引经药治疗偏头痛急性发作的临床疗效。
方法： 选取北京中医药大学东直门医院脑病科门诊2023年7月—2024年6月就诊的偏头痛急性发作患者47例，采用随机数字表法分为A、B两组，在第一阶段（P1）分别使用上清散与布洛芬、模拟剂与布洛芬干预，经过洗脱期后，第二阶段（P2）两组互换治疗方案，每组患者均先后接受两种不同干预方式，观察每组治疗有效率，各阶段治疗前及治疗后2 h、24 h VAS评分和伴随症状积分，服药后24 h、72 h内偏头痛复发情况，并通过对比治疗前后血清指标变化探究其可能的效应靶点。
结果： P1治疗后24 h伴随症状积分、24 h VAS评分及24 h VAS评分下降程度组间差异有统计学意义（P <0.05），血清指标NO治疗前后差值组间差异显著（P <0.05，P <0.01）；P2治疗后2 h、24 hVAS评分及伴随症状积分组间差异无统计学意义（P >0.05）。两阶段中上清散干预后2 h有效率为72.20% （26/36），显著高于模拟剂的34.20% （13/38） （χ2 = 10.716，P ＝0.001），治疗后24 h VAS评分及2 h、24 h伴随症状积分差异有统计学意义（P <0.05），且72 h内偏头痛复发率降低（P <0.01）。
结论： 上清散对偏头痛急性期发作治疗有较好的临床效果，为中医药干预偏头痛提供临床参考。
, authors=路一坤, 韩笑, 周莹, 史华伟, 王芳, 白晶, 董兴鲁, 樊昱颖, 崔方圆
*, authorsList=路一坤, 韩笑, 周莹, 史华伟, 王芳, 白晶, 董兴鲁, 樊昱颖, 崔方圆, authorCompany=null, correspAuthors=崔方圆, authorNote=
路一坤（2000-），女，硕士研究生，从事中医内科学脑病方向相关研究。
, correspAuthorsNote=
* 崔方圆（1981-），女，博士，主任医师，从事中医脑病相关研究。
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路一坤（2000-），女，硕士研究生，从事中医内科学脑病方向相关研究。
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路一坤（2000-），女，硕士研究生，从事中医内科学脑病方向相关研究。
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