Article(id=1307269662891332405, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269637637427792, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260073, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1745683200000, receivedDateStr=2025-04-27, revisedDate=1765468800000, revisedDateStr=2025-12-12, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606975529, onlineDateStr=2026-09-17, pubDate=1776614400000, pubDateStr=2026-04-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606975529, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606975529, creator=13701087609, updateTime=1789606975529, updator=13701087609, issue=Issue{id=1307269637637427792, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='4', pageStart='1', pageEnd='127', issueExtLink='null', onlineDate='null', pubDate='1776614400000', pubDateStr='2026-04-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606969508, creator='13701087609', updateTime=1789606969508, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=39, endPage=44, ext={EN=ArticleExt(id=1307269663122019126, articleId=1307269662891332405, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Study on the Differences in the Effects of Gypenosides on CYP3A2 Enzyme Activity in Normal and Hyperlipidemic Rats, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
To evaluate the effect of gypenosides (Gyps) on CYP3A2 enzyme activity in normal and hyperlipidemia rats by probe drug method.
Methods: The experimental animals were divided into normal rats control group, normal rats Gyps group, hyperlipidemia rats control group, and hyperlipidemia rats Gyps group. The animals in control and Gyps groups were given blank solvent and Gyps for 7 days respectively. On the 8th day, the rats in each groups were given the probe drug (aminopterin). The effect of Gyps on CYP3A2 activity in normal and hyperlipidemic rats was analyzed by detecting blood concentration of probe drug using HPLC method and calculating pharmacokinetic parameters.
Results: Compared with normal rats control group and hyperlipidemia rats control group, AUC, Cmax of dapsone increased, t1/2 was significantly prolonged, and CLz/F significantly decreased both in normal rats Gyps group and hyperlipidemia rats Gyps group (P <0.01). Compared with normal rats control group, AUC of dapsone in hyperlipidemia rats control group significantly increased and the CLz/F significantly decreased (P <0.01). After administration of Gyps, compared with normal rats Gyps group, the increase of AUC and decrease of CLz/F of dapsone in hyperlipidemia rats Gyps group were more significant (P <0.01).
Conclusion: The activity of CYP3A2 enzyme in rats can be inhibited by Gyps. The results suggest that the dosage of drug should be adjusted to avoid the potential risk of herb-drug interactions when Gyps is combined with drugs metabolized by CYP3A4, especially in hyperlipidemia.
, authors=Weihong YIN, Jiao LI, Siwen WANG, Chao YU, Mingyu CUI
*, authorsList=Weihong YIN, Jiao LI, Siwen WANG, Chao YU, Mingyu CUI, authorCompany=null, correspAuthors=Mingyu CUI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269665084953399, articleId=1307269662891332405, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=绞股蓝总苷对正常与高脂血症大鼠体内CYP3A2酶活性影响的差异性研究, columnId=1303760928135213534, journalTitle=中医药学报, columnName=中药研究, runingTitle=null, highlight=null, articleAbstract=
目的： 利用探针药物法评价绞股蓝总苷（Gyps）对正常和高脂血症大鼠体内CYP3A2酶活性的影响。
方法： 实验动物分为正常大鼠对照组、正常大鼠Gyps组、高脂大鼠对照组、高脂大鼠Gyps组。对照组及Gyps组分别连续给予空白溶剂及Gyps 7 d。第8天，各组大鼠均灌胃给予探针药物氨苯砜1次。采用HPLC法测定各组探针药物的血药浓度并计算其药动学参数，分析Gyps对正常和高脂血症大鼠体内CYP3A2酶活性的影响。
结果： 与正常大鼠对照组和高脂大鼠对照组相比，给予Gyps干预后，正常大鼠Gyps组和高脂大鼠Gyps组中氨苯砜的AUC、Cmax显著升高，t1/2显著延长，CLz/F显著降低（P <0.01）。高脂大鼠对照组与正常大鼠对照组相比，氨苯砜的AUC显著升高，CLz/F显著下降（P < 0.01）。在给予Gyps后，与正常大鼠Gyps组相比，高脂大鼠Gyps组中氨苯砜AUC的升高及CLz/F的下降程度更为显著（P <0.01）。
结论： Gyps可抑制大鼠体内CYP3A2酶的活性，提示临床中Gyps与经人体CYP3A4代谢药物联用时，应注意调整药物剂量以规避潜在的药物相互作用风险，在高脂血症状态下更应引起注意。
, authors=尹卫红, 李娇, 王思雯, 于超, 崔明宇
*, authorsList=尹卫红, 李娇, 王思雯, 于超, 崔明宇, authorCompany=null, correspAuthors=崔明宇, authorNote=
尹卫红（1998-），男，硕士研究生，从事药物动力学及临床药学研究。
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* 崔明宇（1971-），女，博士，副教授，从事中药活性成分及药物动力学研究。
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尹卫红（1998-），男，硕士研究生，从事药物动力学及临床药学研究。
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尹卫红（1998-），男，硕士研究生，从事药物动力学及临床药学研究。
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