Article(id=1307269658197906184, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269637637427792, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260086, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1731945600000, receivedDateStr=2024-11-19, revisedDate=1755878400000, revisedDateStr=2025-08-23, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606974410, onlineDateStr=2026-09-17, pubDate=1776614400000, pubDateStr=2026-04-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606974410, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606974410, creator=13701087609, updateTime=1789606974410, updator=13701087609, issue=Issue{id=1307269637637427792, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='4', pageStart='1', pageEnd='127', issueExtLink='null', onlineDate='null', pubDate='1776614400000', pubDateStr='2026-04-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606969508, creator='13701087609', updateTime=1789606969508, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=112, endPage=118, ext={EN=ArticleExt(id=1307269658386649865, articleId=1307269658197906184, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Research Progress on the Pathogenesis of Ischemic Stroke and Traditional Chinese Medicine Intervention Based on the JAK2/STAT3 Signaling Pathway, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Ischemic stroke (IS) is a disease caused by sudden blockage of cerebral blood vessels leading to brain tissue damage, resulting in irreversible local neurological deficits and seriously threatening patients' lives and health. Currently, there are no particularly effective clinical treatments for this disease. The Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is a key pathway affecting the occurrence and development of IS. Traditional Chinese medicine (TCM) exerts neuroprotective effects by regulating the JAK2/STAT3 signaling pathway, which has become an emerging direction for exploring IS treatment. This article takes the JAK2/STAT3 signaling pathway as the starting point, comprehensively reviews the regulatory role of this signaling pathway in IS pathological processes such as inflammatory response, apoptosis, cell proliferation and differentiation, and angiogenesis, analyzes recent research progress on TCM regulation of this signaling pathway to intervene in IS, and explores the potential of TCM compounds and their active components in improving IS symptoms and promoting neurological function recovery, thereby revealing the targets of TCM action and providing theoretical references for clinical treatment of IS.

, authors=Yaoyao LIU^{1, 2}, Qi WANG^{1, 2}, Ziwen HOU^{1, 2}, Peng LI^{1, 2, *}, authorsList=Yaoyao LIU, Qi WANG, Ziwen HOU, Peng LI, authorCompany=null, correspAuthors=Peng LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269658684445450, articleId=1307269658197906184, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=基于JAK2/STAT3信号通路探讨缺血性脑卒中发病机制及中药干预研究进展, columnId=1303760941036888710, journalTitle=中医药学报, columnName=研究进展, runingTitle=null, highlight=null, articleAbstract=

缺血性脑卒中（IS）是由于脑部血管突然阻塞导致脑组织损伤的疾病，可产生不可逆的局部神经功能缺失，严重威胁患者的生命健康。目前临床上针对该病尚无特别有效的治疗方法。Janus激酶2 （JAK2）/信号转导与转录激活因子3（STAT3）信号通路是影响IS发生发展的关键通路。中药可通过调节JAK2/STAT3信号通路发挥神经保护作用，已成为探索治疗IS的新兴方向。本文以JAK2/STAT3信号通路为切入点，详细综述了该信号通路对炎症反应、细胞凋亡、细胞增殖分化、血管生成等IS病理过程的调控作用，并分析近年来中药调控此信号通路干预IS的研究进展，探讨中药单体化合物、中药复方及注射液在改善IS症状、促进神经功能恢复的潜力，从而揭示中药的作用靶点，为临床治疗IS提供一定的理论参考。

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刘瑶瑶（1998-），女，硕士研究生，研究方向：针药结合治疗脑血管病。

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刘瑶瑶（1998-），女，硕士研究生，研究方向：针药结合治疗脑血管病。

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