中医药学报

孔圣枕中丹化裁方对肾虚痰瘀型脑小血管病患者认知功能、炎症因子及中医证候积分的影响

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宋高伟 ¹ , 张强强 ² , 王琢 ¹ , 杨林肖 ² , 杨思清 ² , 杨琳 ²^,^*

中医药学报 | 临床研究 2026,54(5): 82-86

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中医药学报 |临床研究 2026 , 54 (5) : 82 -86

孔圣枕中丹化裁方对肾虚痰瘀型脑小血管病患者认知功能、炎症因子及中医证候积分的影响

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宋高伟¹, 张强强², 王琢¹, 杨林肖², 杨思清², 杨琳²^,^*

作者信息

^1.陕西中医药大学，陕西咸阳 712046

^2.西安市中医医院，陕西西安 710021

通讯作者:

^* 杨琳（1970-），女，主任医师，主要从事脑病的中西医防治研究。

作者简介:

宋高伟（1993-），男，硕士研究生，主要从事中西医结合脑血管病的防治研究。

Effects of Modified Kongsheng Zhenzhong Pill on Cognitive Function, Inflammatory Factors, and Traditional Chinese Medicine Syndrome Scores in Patients with Cerebral Small Vessel Disease of Kidney Deficiency and Phlegm-Stasis Type

Gaowei SONG¹, Qiangqiang ZHANG², Zhuo WANG¹, Linxiao YANG², Siqing YANG², Lin YANG²^,^*

Affiliations

^1.Shaanxi University of Chinese Medicine, Xianyang 712046, China

^2.Xi'an Hospital of Traditional Chinese Medicine, Xi'an 710021, China

出版时间: 2026-05-20 doi: 10.19664/j.cnki.1002-2392.260102

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摘要

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目的：

探讨孔圣枕中丹化裁方对肾虚痰瘀型脑小血管病（CSVD）患者认知功能、炎症因子及中医证候积分的影响。

方法：

回顾性选取西安市中医医院脑病科2020年1月—2025年1月CSVD（肾虚痰瘀型）住院患者210例，其中接受常规治疗的104例患者纳入基础组，在常规治疗基础上接受孔圣枕中丹化裁方治疗的106例患者纳入研究组，对比两组临床疗效、认知功能［蒙特利尔量表（MoCA）与简易精神状态评价量表（MMSE）］、炎症因子［超敏C反应蛋白（hs-CRP）、白细胞介素（IL）-1β、IL-6］及中医证候积分。

结果：

研究组总有效率高于基础组，差异有统计学意义（P < 0.05）。两组治疗前认知功能各项评分比较，差异无统计学意义（P > 0.05），研究组患者治疗后MoCA评分及MMSE评分均高于基础组（P < 0.01）。两组治疗前炎症因子比较，差异无统计学意义（P > 0.05），研究组治疗后hs-CRP、IL-1β及IL-6水平均低于基础组（P < 0.01）。两组治疗前中医证候各项积分比较，差异无统计学意义（P > 0.05）；研究组治疗后智能减退、咯痰、纳呆脘胀、大便黏腻等证候积分均低于基础组（P <0.01）。

结论：

针对CSVD（肾虚痰瘀型）患者应用孔圣枕中丹化裁方，可获得显著疗效，促使患者认知功能及中医证候改善，降低其炎症因子水平，疗效优于单纯常规治疗。

关键词

孔圣枕中丹化裁方 / 脑小血管病 / 肾虚痰瘀型 / 认知功能 / 炎症因子

Abstract

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Objective:

To investigate the effects of Kongsheng Zhenzhong Pill Modified Formula on cognitive function, inflammatory factor and Chinese medicine syndrome score in patients with cerebral small vessel disease (CSVD) with kidney deficiency, phlegm and stasis type.

Methods:

A retrospective selection was made of 210 inpatients with CSVD (kidney deficiency and phlegm-stasis type) from the Department of Neurology of Xi'an Hospital of Traditional Chinese Medicine from January 2020 to January 2025, among which 104 patients receiving conventional treatment were included in the basic group and 106 patients who received the modified formula of Kongsheng Zhenzhong Pill Modified Formula on the basis of conventional treatment were included in the study group, and the efficacy of the 2 groups, cognitive function [Montreal Scale (MoCA) and the Simple Mental State Evaluation (MMSE) scale], inflammatory factors (Hypercalcitrance and inflammation factor), and inflammatory factors (Hypercalcitrance and inflammation factor) were compared with those in the other group, inflammatory factors [Hypersensitive C-reactive protein (hs-CRP), interleukin (IL) -1β, IL-6] and TCM evidence score.

Results:

Among the 210 patients with CSVD (kidney deficiency and phlegm-stasis type) in this study, 106 cases were included in the study group and 104 cases in the control group. The total effective rate of the study group was higher than that of the basic group, and the difference was statistically significant (P <0.05). Comparison of various scores of cognitive function before treatment between the two groups showed no significant difference (P >0.05), and the MoCA score and MMSE score of patients in the study group were higher than those in the basic group after treatment (P < 0.05). Comparison of inflammatory factors before treatment between the two groups, there was no significant difference (P >0.05), and the levels of hs-CRP, IL-1β and IL-6 were lower than those of the basic group after treatment in the study group (P < 0.05). There was no significant difference between the two groups when comparing the points of Chinese medicine symptoms before treatment (P > 0.05), and the points of symptoms such as diminished intelligence, phlegm, nausea and epigastric distension, and sticky stools were lower than those of the basic group after the treatment in the research group (P < 0.05).

Conclusion:

The application of Kongsheng Zhenzhong Pill Modified Formula for CSVD (kidney deficiency, phlegm and stasis type) patients can achieve significant therapeutic effects, improve cognitive function and Chinese medicine symptoms, and reduce the level of inflammatory factors in the patients. The therapeutic effect is superior to that of conventional treatment alone.

Key words

Kongsheng Zhenzhong Pill Modified Formula / Cerebral small vessel disease / Renal deficiency, Phlegm stasis type / Cognitive function / Inflammatory factor

引用本文

宋高伟, 张强强, 王琢, 杨林肖, 杨思清, 杨琳. 孔圣枕中丹化裁方对肾虚痰瘀型脑小血管病患者认知功能、炎症因子及中医证候积分的影响. 中医药学报, 2026 , 54 (5) : 82 -86 . DOI: 10.19664/j.cnki.1002-2392.260102

Gaowei SONG, Qiangqiang ZHANG, Zhuo WANG, Linxiao YANG, Siqing YANG, Lin YANG. Effects of Modified Kongsheng Zhenzhong Pill on Cognitive Function, Inflammatory Factors, and Traditional Chinese Medicine Syndrome Scores in Patients with Cerebral Small Vessel Disease of Kidney Deficiency and Phlegm-Stasis Type[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (5) : 82 -86 . DOI: 10.19664/j.cnki.1002-2392.260102

基金

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西安市卫生健康委项目(2025ms02)

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2026年第54卷第5期

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文章信息

doi: 10.19664/j.cnki.1002-2392.260102

接收时间：2025-06-26
首发时间：2026-09-17
出版时间：2026-05-20

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出版历史

收稿日期：2025-06-26
修回日期：2026-03-30

基金

西安市卫生健康委项目(2025ms02)

作者信息

^1.陕西中医药大学，陕西咸阳 712046

^2.西安市中医医院，陕西西安 710021

通讯作者:

^* 杨琳（1970-），女，主任医师，主要从事脑病的中西医防治研究。

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https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260102

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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