Article(id=1307269633812230597, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269601637724372, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260101, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1748880000000, receivedDateStr=2025-06-03, revisedDate=1774540800000, revisedDateStr=2026-03-27, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606968595, onlineDateStr=2026-09-17, pubDate=1779206400000, pubDateStr=2026-05-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606968595, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606968595, creator=13701087609, updateTime=1789606968595, updator=13701087609, issue=Issue{id=1307269601637724372, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='5', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1779206400000', pubDateStr='2026-05-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606960925, creator='13701087609', updateTime=1789606960925, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=77, endPage=81, ext={EN=ArticleExt(id=1307269633980002758, articleId=1307269633812230597, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Clinical Observation of Huanglian Qingjie Granules Combined with Improved Combination Therapy in the Treatment Chronic Gastritis (Spleen and Stomach Damp-Heat Type) with Helicobacter Pylori Eradication Failure, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate the clinical effect of Huanglian Qingjie Granule combined with improved combination therapy on spleen and stomach damp-heat type patients with chronic gastritis whose eradication of Helicobacter pylori (Hp) failed.
Methods: The research subjects were 82 patients with chronic gastritis of the spleen and stomach damp-heat type who failed the initial eradication of Hp and were admitted to Zhengzhou Hospital of Traditional Chinese Medicine from January 2023 to April 2025. They were divided into two groups according to a randomized, parallel controlled design: the control group and the treatment group, with 41 patients in each group. The control group was treated with modified double therapy, and the treatment group was treated with Huanglian Qingjie Granule on the basis of the control group. Both groups were treated for 1 month. The clinical efficacy of the two groups was compared. The Hp clearance of the two groups was compared one month after treatment. The TCM syndrome scores of the two groups were compared before treatment and one month after treatment. The levels of inflammatory factors were compared between the two groups before and 1 month after treatment.
Results: Compared with the control group, the total effective rate was significantly higher in the treatment group (P < 0.05). Compared with control group, Hp clearance rate in treatment group was significantly higher (P < 0.05). Compared with the control group, the main symptom score and secondary symptom score of TCM syndrome score were significantly decreased in the treatment group one month after treatment (P < 0.05). Compared with the control group, the levels of tumor necrosis factor-α (TNF-α) and interleukin-1 β (IL-1β) were significantly decreased in the treatment group one month after treatment, and the level of interleukin-10 (IL-10) was significantly increased in the treatment group (P < 0.05).
Conclusion: The combination of Huanglian Qingjie Granules and the modified dual therapy can effectively enhance the clinical efficacy of patients with chronic gastritis of spleen and stomach damp-heat type who have failed Hp eradication, increase the Hp eradication rate of patients, improve their TCM syndrome score and inflammatory factor levels, and can be widely applied in clinical practice.
, authors=Xianglin MENG, Bin ZHAO, Hailei LI, Hongwei LUO
*, authorsList=Xianglin MENG, Bin ZHAO, Hailei LI, Hongwei LUO, authorCompany=null, correspAuthors=Hongwei LUO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269634370073031, articleId=1307269633812230597, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=黄连清解颗粒联合改良二联疗法治疗幽门螺杆菌根除失败的慢性胃炎
(脾胃湿热型
)临床观察, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探讨黄连清解颗粒联合改良二联疗法对幽门螺杆菌（Hp）根除失败的慢性胃炎脾胃湿热型患者的临床疗效。
方法： 选取郑州市中医院2023年1月—2025年4月收治的Hp初次根除失败的慢性胃炎脾胃湿热型患者82例，依据随机、平行对照设计分为对照组和治疗组，每组41例。对照组给予改良二联疗法治疗，治疗组在对照组基础上联用黄连清解颗粒治疗，两组均治疗1个月。对比两组临床疗效；比较两组治疗后1个月Hp根除情况；比较两组治疗前后中医证候积分；对比两组治疗前后炎症因子水平。
结果： 与对照组比较，治疗组临床总有效率明显更高（P < 0.05），Hp根除率明显更高（P <0.05），与对照组比较，治疗组治疗后中医证候积分主症评分和次症评分均显著降低（P < 0.01）；与对照组比较，治疗组肿瘤坏死因子-α（TNF-α）、白细胞介素-1β （IL-1β）水平治疗后均显著降低（P <0.01），治疗组白细胞介素-10（IL-10）水平显著升高（P < 0.01）。
结论： 黄连清解颗粒联合改良二联疗法可以有效提升Hp根除失败的慢性胃炎脾胃湿热型患者临床疗效，增加患者Hp根除率，改善其中医证候积分和炎症因子水平，可广泛应用于临床。
, authors=孟祥林, 赵彬, 李海雷, 罗宏伟
*, authorsList=孟祥林, 赵彬, 李海雷, 罗宏伟, authorCompany=null, correspAuthors=罗宏伟, authorNote=
孟祥林（1986-），男，硕士，副主任中医师，从事中医药防治肝胆脾胃疾病相关研究。
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* 罗宏伟（1966-），男，主任中医师，从事中医药防治肝胆脾胃疾病相关研究。
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孟祥林（1986-），男，硕士，副主任中医师，从事中医药防治肝胆脾胃疾病相关研究。
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孟祥林（1986-），男，硕士，副主任中医师，从事中医药防治肝胆脾胃疾病相关研究。
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