Article(id=1307269622558904869, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269601637724372, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260109, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1727193600000, receivedDateStr=2024-09-25, revisedDate=1745337600000, revisedDateStr=2025-04-23, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606965913, onlineDateStr=2026-09-17, pubDate=1779206400000, pubDateStr=2026-05-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606965913, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606965913, creator=13701087609, updateTime=1789606965913, updator=13701087609, issue=Issue{id=1307269601637724372, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='5', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1779206400000', pubDateStr='2026-05-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606960925, creator='13701087609', updateTime=1789606960925, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=121, endPage=126, ext={EN=ArticleExt(id=1307269624425370150, articleId=1307269622558904869, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Research Progress on the Combination of Astragali Radix and Rhei Radix et Rhizoma in Treating Chronic Kidney Disease, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Chronic kidney disease (CKD) is a common chronic condition characterized by structural damage or functional decline of the kidneys due to various causes. According to Traditional Chinese Medicine (TCM) theory, the primary pathogenesis of CKD is "spleen-kidney qi deficiency and turbid toxin accumulation" and "tonifying qi and dispelling turbidity" is the fundamental treatment principle. Astragali Radix and Rhei Radix et Rhizoma are classically served as a herb pair for "tonifying qi and dispelling turbidity" and are frequently used in CKD treatment. With the rapid advancement of TCM modernization, an in-depth analysis of the mechanisms of herbal comination is of great significance for enriching the scientific connotation of TCM theory and guiding clinical diagnosis and treatment. This article first summarizes the main chemical components and pharmacological effects of Astragali Radix and Rhei Radix et Rhizoma from the perspective of modern medicine. It then analyzes the TCM understanding of their roles in treating CKD. On this basis, integrating modern medical and TCM theories, it discusses the research progress on the Astragali Radix-Rhei Radix et Rhizoma combination in CKD treatment. Furthermore, it highlights current limitations and future research directions, aiming to provide new insights for the clinical management and drug development of CKD.

, authors=Ping WU, Xiaolin LI, Jinhu LI, Tianlong LIU, Minna LIU*, authorsList=Ping WU, Xiaolin LI, Jinhu LI, Tianlong LIU, Minna LIU, authorCompany=null, correspAuthors=Minna LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269624819634727, articleId=1307269622558904869, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=黄芪-大黄配伍抗慢性肾脏病研究进展, columnId=1303760941036888710, journalTitle=中医药学报, columnName=研究进展, runingTitle=null, highlight=null, articleAbstract=

慢性肾脏病(CKD)是多种原因引起的以肾脏结构损伤或功能下降为特征的常见慢性疾病。根据中医理论,CKD主要病机为脾肾气虚、浊毒内蕴,益气降浊是其主要治则。黄芪-大黄是经典的“益气降浊”药对,在CKD治疗中常配伍使用。随着中医药现代化的快速发展,深入解析中药配伍机制,对丰富中医药理论的科学内涵和指导临床诊疗实践具有重要意义。本文首先从现代医学角度总结了黄芪、大黄的主要化学成分和药理作用,其次从中医药理论层面分析了黄芪、大黄抗慢性肾脏病的中医认识。最后在此基础上,结合现代医学及中医药理论,探讨了大黄-黄芪配伍抗CKD的研究进展,并基于当前的研究现状提出了不足和展望,以期为CKD的临床治疗和药物开发提供新的思路。

, authors=吴萍, 李晓琳, 李进虎, 刘天龙, 柳敏娜*, authorsList=吴萍, 李晓琳, 李进虎, 刘天龙, 柳敏娜, authorCompany=null, correspAuthors=柳敏娜, authorNote=

吴萍(1978-),女,主治医师,研究方向:慢性肾脏病中医药防治。

, correspAuthorsNote=
* 柳敏娜(1992-),女,硕士,主治医师,硕士研究生导师,研究方向:慢性肾脏病中医药防治。
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吴萍(1978-),女,主治医师,研究方向:慢性肾脏病中医药防治。

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吴萍(1978-),女,主治医师,研究方向:慢性肾脏病中医药防治。

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黄芪-大黄配伍抗慢性肾脏病研究进展
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吴萍 , 李晓琳 , 李进虎 , 刘天龙 , 柳敏娜 *
中医药学报 | 研究进展 2026,54(5): 121-126
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中医药学报 |研究进展 2026 , 54 (5) : 121 -126
黄芪-大黄配伍抗慢性肾脏病研究进展
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吴萍, 李晓琳, 李进虎, 刘天龙, 柳敏娜*
作者信息
  • 联勤保障部队第九四〇医院,甘肃 兰州 730050
通讯作者:
* 柳敏娜(1992-),女,硕士,主治医师,硕士研究生导师,研究方向:慢性肾脏病中医药防治。
作者简介:

吴萍(1978-),女,主治医师,研究方向:慢性肾脏病中医药防治。

Research Progress on the Combination of Astragali Radix and Rhei Radix et Rhizoma in Treating Chronic Kidney Disease
Ping WU, Xiaolin LI, Jinhu LI, Tianlong LIU, Minna LIU*
Affiliations
  • The 940th Hospital Joint Logistics Support Force of PLA, Lanzhou 730050, China
出版时间: 2026-05-20 doi: 10.19664/j.cnki.1002-2392.260109
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慢性肾脏病(CKD)是多种原因引起的以肾脏结构损伤或功能下降为特征的常见慢性疾病。根据中医理论,CKD主要病机为脾肾气虚、浊毒内蕴,益气降浊是其主要治则。黄芪-大黄是经典的“益气降浊”药对,在CKD治疗中常配伍使用。随着中医药现代化的快速发展,深入解析中药配伍机制,对丰富中医药理论的科学内涵和指导临床诊疗实践具有重要意义。本文首先从现代医学角度总结了黄芪、大黄的主要化学成分和药理作用,其次从中医药理论层面分析了黄芪、大黄抗慢性肾脏病的中医认识。最后在此基础上,结合现代医学及中医药理论,探讨了大黄-黄芪配伍抗CKD的研究进展,并基于当前的研究现状提出了不足和展望,以期为CKD的临床治疗和药物开发提供新的思路。

慢性肾脏病  /  黄芪  /  大黄  /  协同配伍  /  益气降浊

Chronic kidney disease (CKD) is a common chronic condition characterized by structural damage or functional decline of the kidneys due to various causes. According to Traditional Chinese Medicine (TCM) theory, the primary pathogenesis of CKD is "spleen-kidney qi deficiency and turbid toxin accumulation" and "tonifying qi and dispelling turbidity" is the fundamental treatment principle. Astragali Radix and Rhei Radix et Rhizoma are classically served as a herb pair for "tonifying qi and dispelling turbidity" and are frequently used in CKD treatment. With the rapid advancement of TCM modernization, an in-depth analysis of the mechanisms of herbal comination is of great significance for enriching the scientific connotation of TCM theory and guiding clinical diagnosis and treatment. This article first summarizes the main chemical components and pharmacological effects of Astragali Radix and Rhei Radix et Rhizoma from the perspective of modern medicine. It then analyzes the TCM understanding of their roles in treating CKD. On this basis, integrating modern medical and TCM theories, it discusses the research progress on the Astragali Radix-Rhei Radix et Rhizoma combination in CKD treatment. Furthermore, it highlights current limitations and future research directions, aiming to provide new insights for the clinical management and drug development of CKD.

Chronic kidney disease  /  Astragali Radix  /  Rhei Radix et Rhizoma  /  Synergistic compatibility  /  Tonifying qi and dispelling turbidity
吴萍, 李晓琳, 李进虎, 刘天龙, 柳敏娜. 黄芪-大黄配伍抗慢性肾脏病研究进展. 中医药学报, 2026 , 54 (5) : 121 -126 . DOI: 10.19664/j.cnki.1002-2392.260109
Ping WU, Xiaolin LI, Jinhu LI, Tianlong LIU, Minna LIU. Research Progress on the Combination of Astragali Radix and Rhei Radix et Rhizoma in Treating Chronic Kidney Disease[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (5) : 121 -126 . DOI: 10.19664/j.cnki.1002-2392.260109
  • 国家自然科学基金项目(82204746)
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doi: 10.19664/j.cnki.1002-2392.260109
  • 接收时间:2024-09-25
  • 首发时间:2026-09-17
  • 出版时间:2026-05-20
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  • 收稿日期:2024-09-25
  • 修回日期:2025-04-23
基金
国家自然科学基金项目(82204746)
作者信息
    联勤保障部队第九四〇医院,甘肃 兰州 730050

通讯作者:

* 柳敏娜(1992-),女,硕士,主治医师,硕士研究生导师,研究方向:慢性肾脏病中医药防治。
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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